LEADER 01393nam 2200433 450 001 9910794319403321 005 20230223205243.0 010 $a1-78680-751-3 035 $a(CKB)4100000011470568 035 $a(MiAaPQ)EBC6355660 035 $a(NjHacI)994100000011470568 035 $a(EXLCZ)994100000011470568 100 $a20230223d2020 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe cost of free shipping $eAmazon in the global economy /$fedited by Jake Alimahomed-Wilson, Ellen Reese 210 1$aLondon :$cPluto Press,$d2020. 215 $a1 online resource (xiii, 300 pages) $cillustrations 225 1 $aWildcat (Pluto Press) 311 $a0-7453-4147-0 330 $a'Amazon Capitalism' grows ever stronger. This book provides the answers on how to fight the company's terrifying omnipotence. 410 0$aWildcat (Pluto Press) 517 $aCost of Free Shipping 606 $aCorporate power$zUnited States 606 $aCapitalism 615 0$aCorporate power 615 0$aCapitalism. 676 $a338.740973 702 $aAlimahomed-Wilson$b Jake 702 $aReese$b Ellen 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910794319403321 996 $aThe cost of free shipping$92018196 997 $aUNINA LEADER 03591nam 22005775 450 001 9910298438603321 005 20260630163916.0 010 $a3-319-73238-2 024 7 $a10.1007/978-3-319-73238-1 035 $a(CKB)4100000003359275 035 $a(MiAaPQ)EBC5372066 035 $a(DE-He213)978-3-319-73238-1 035 $a(PPN)226698580 035 $a(EXLCZ)994100000003359275 100 $a20180425d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAccelerated Path to Cures /$fedited by Josep Bassaganya-Riera 205 $a1?. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (88 pages) 311 08$a3-319-73237-4 327 $aChapter 1: Introduction to Accelerated Path to Cures and Precision Medicine in Inflammatory Bowel Disease -- Chapter 2: Computer-Aided Drug Discovery -- Chapter 3: Preclinical Studies: Efficacy and Safety -- Chapter 4: From Nutritional Immunology to Drug Development -- Chapter 5: Development of Synthetic Patient Populations and In Silico Clinical Trials. 330 $aAccelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures. . 606 $aImmunology 606 $aBioinformatics 606 $aMedical informatics 606 $aBioinformatics 606 $aComputational biology 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aComputational Biology/Bioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/I23050 606 $aHealth Informatics$3https://scigraph.springernature.com/ontologies/product-market-codes/I23060 606 $aComputer Appl. in Life Sciences$3https://scigraph.springernature.com/ontologies/product-market-codes/L17004 615 0$aImmunology. 615 0$aBioinformatics. 615 0$aMedical informatics. 615 0$aBioinformatics. 615 0$aComputational biology. 615 14$aImmunology. 615 24$aComputational Biology/Bioinformatics. 615 24$aHealth Informatics. 615 24$aComputer Appl. in Life Sciences. 676 $a615.190285 702 $aBassaganya-Riera$b Josep,$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298438603321 996 $aAccelerated Path to Cures$92544113 997 $aUNINA