LEADER 05160oam 2200541K 450 001 9910793578003321 005 20190426110706.0 010 $a1-351-38016-8 010 $a1-351-38015-X 010 $a1-315-14628-2 024 7 $a10.4324/9781315146287 035 $a(CKB)4100000007805877 035 $a(MiAaPQ)EBC5732255 035 $a(OCoLC)1090130295 035 $a(OCoLC-P)1090130295 035 $a(FlBoTFG)9781315146287 035 $a(EXLCZ)994100000007805877 100 $a20190319d2019 uy 0 101 0 $aeng 135 $aurcnu---unuuu 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe Routledge handbook of sport and exercise systems genetics /$fedited by J. Timothy Lightfoot, Monica J. Hubal, and Stephen M. Roth 210 1$aAbingdon, Oxon ;$aNew York, NY :$cRoutledge,$d2019. 215 $a1 online resource (543 pages) 225 0 $aRoutledge international handbooks 311 $a1-138-50485-8 327 $aCover; Half Title; Title Page; Copyright Page; Table of contents; List of Figures; List of Tables; List of Contributors; Foreword; Preface; Introduction; References; Section 1 General systems genetics; 1 Why study the systems genetics of sport and exercise?; Introduction; Exercise systems genomics; Exercise presents a high stress; however, the body is able to survive by maintaining its homeostasis...; Exercise systems genetics versus inactivity systems genetics; Physical inactivity is a necessary reference group to show healthy exercise effects -- and turns... 327 $aA biased positive look to the futureA projection into where technology seems to be taking physical inactivity; Multiple, biased, concerned looks to the future; New technology is often based upon reducing physical activity; Inheritance of low voluntary running behavior; Does epigenetics play a role in type 2 diabetes and in physical inactivity?; Low voluntary running animal model to mimic increased human inactivity; The high economic costs of physical inactivity are contributing in their small way to the bankruptcy of our children's future cost of living 327 $aWhat systems genetics could do for humansReferences; 2 Expansion of knowledge and advances in genetics for quantitative analyses; Introduction; The Human Genome Project; Advances in sequencing; Association studies; Noncoding sequences; Noncoding RNA and antisense sequences; MicroRNAs; Exosomes; Epigenetics; Summary; References; 3 human systems genetic modeling used in exercise; Introduction; Study of families; What are families?; Quantifying family data; Twin studies; Biology of twins and twinning; The classical twin model; Basic concepts of the twin model; The univariate twin model 327 $aMultivariate twin modelsMZ discordant pairs to study causal associations; Adoption studies; Twin family designs; Genome-wide association studies; The future in the era of molecular genetics; Further reading; References; 4 The translation of systems genetics of exercise to everyday life; Introduction; Theoretical foundations of exercise interventions; Translating exercise genomics into practice; Using genetic information to enhance exercise adherence; Using genetic information to enhance exercise prescription and intervention 327 $aUsing genetic information to identify individuals at risk for exercise dropoutConclusion; References; Section 2 Systems genetics of physical activity; 5 Is physical activity regulated by genetics? Evidence from animal models; What is physical activity in an animal model?; Heritability; Genetic architecture; Genetic mapping; Fine-mapping approaches; Future directions; References; 6 Is physical activity regulated by genetics? Evidence from studies in humans; Introduction; Twin studies; Physical activity phenotypes; Meta-analyses; Results for total physical activity 330 $a"The Routledge Handbook of Sport and Exercise Systems Genetics constitutes the most authoritative and comprehensive reference in this critical area of study, consolidating knowledge and providing a framework for interpreting future research findings. Taking an approach which covers single gene variations, through genomics, epigenetics and proteomics, to environmental and dietary influences on genetic mechanisms, the book is divided into six sections. It examines state-of-the-art genetic methods, applies its approach to physical activity, exercise endurance, muscle strength and sports performance, and discusses the ethical considerations associated with genetic research in sport and exercise"--$cProvided by publisher. 606 $aHuman genetics$xResearch 606 $aSports$xPhysiological aspects$xResearch 615 0$aHuman genetics$xResearch. 615 0$aSports$xPhysiological aspects$xResearch. 676 $a612.044 702 $aLightfoot$b J. Timothy 702 $aHubal$b Monica J. 702 $aRoth$b Stephen M.$f1973- 801 0$bOCoLC-P 801 1$bOCoLC-P 906 $aBOOK 912 $a9910793578003321 996 $aThe Routledge handbook of sport and exercise systems genetics$93699776 997 $aUNINA LEADER 03100nam 22004813 450 001 9910163324103321 005 20250731080249.0 010 $a9781782898016 010 $a1782898018 035 $a(CKB)3810000000098065 035 $a(BIP)058039537 035 $a(VLeBooks)9781782898016 035 $a(Perlego)3018462 035 $a(MiAaPQ)EBC32230123 035 $a(Au-PeEL)EBL32230123 035 $a(Exl-AI)993810000000098065 035 $a(Exl-AI)32230123 035 $a(OCoLC)1530376555 035 $a(EXLCZ)993810000000098065 100 $a20250731d2014 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Bombing of Brittany 205 $a1st ed. 210 1$aBielefeld :$cPickle Partners Publishing,$d2014. 210 4$dİ2014. 215 $a1 online resource (59 p.) 327 $aTitle page -- TABLE OF CONTENTS -- Abstract -- Introduction -- Operational Approach -- Attacks on Brest -- Attacks on Lorient -- Attacks on St. Nazaire -- Analyzing the Operational Approach -- Operational Environment -- The Coastal Cities -- The Enemy?s Operational Environment -- Construction -- Institutional Barriers -- Summary of Operational Environment -- The Problem Frame -- The U-Boat Threat -- Analysis of Problem Frame -- Defining Problems -- Conclusion -- BIBLIOGRAPHY$7Generated by AI. 330 8 $aAs a result of the Allied bombing campaign against Nazi submarine bases during the Second World War, the cities of Brest, Lorient, and Saint Nazaire were nearly completely destroyed. Despite thousands of bombing missions, all three submarine bunkers still stand today. This monograph examines the effectiveness of the Allied bombing campaign against German submarine bases in Brittany by analyzing the campaign through the use of a design methodology. Research is broken down into three frames: the operational approach, the operational environment and the problem frame. The first frame provides an account of the bombing missions and effects. Next, an overview of the operational environment is conducted by exploring the historical context of Brittany, German construction efforts and Allied institutional barriers. The study concludes by examining the problem frame, which entails how the Allies perceived their operational problem and developed an approach based on their understanding. Ultimately, the Allies failed to accurately identify their problem and developed an ineffective approach towards defeating the threat. Had the Allies incorporated design thinking into their planning and execution, they may have developed an effective campaign towards defeating the Nazi U-boat threat rather than solving the wrong problem. 606 $aNaval strategy$7Generated by AI 615 0$aNaval strategy 676 $a940.544 700 $aHeathman$b Jeremiah S$01835638 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910163324103321 996 $aThe Bombing of Brittany$94412416 997 $aUNINA