LEADER 04194nam 2200745 450 001 9910252741803321 005 20201016235141.0 010 $a2-7606-3069-2 010 $a2-8218-9497-X 010 $a2-7606-2582-6 024 7 $a10.4000/books.pum.2227 035 $a(CKB)2560000000055943 035 $a(EBL)3272871 035 $a(OCoLC)923774396 035 $a(SSID)ssj0001630152 035 $a(PQKBManifestationID)16376717 035 $a(PQKBTitleCode)TC0001630152 035 $a(PQKBWorkID)14942540 035 $a(PQKB)11733785 035 $a(MiAaPQ)EBC4749984 035 $a(CEL)434853 035 $a(CaBNvSL)slc00226300 035 $a(MiAaPQ)EBC3272871 035 $a(FrMaCLE)OB-pum-2227 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/51739 035 $a(VaAlCD)20.500.12592/9ssm99 035 $a(PPN)221484000 035 $a(EXLCZ)992560000000055943 100 $a20161216h20092009 uy 0 101 0 $afre 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aLes limites du soi $eimmunologie et identite? biologique /$fThomas Pradeu 210 $cPresses de l?Université de Montréal$d2010 210 1$aMontre?al, [Quebec?bec] :$cLes Presses de l'Universite? de Montre?al,$d2009. 210 4$d©2009 215 $a1 online resource (395 p.) 225 1 $aAnalytiques ;$v18 300 $aPubl. en collab. avec: Vrin. 311 $a2-7606-2196-0 320 $aIncludes bibliographical references and index. 327 $aComment de?finir l'immunologie et ses deux concepts centraux, le soi et le non-soi? -- Que signifient les termes "soi" et "non-soi" en immunologie -- Pourquoi la the?orie du soi et du non-soi s'est-elle impose?e a? l'immunologie? -- Les insuffisances de la the?orie du soi et du non-soi -- Fondements et de?tails de la the?orie de la continuite? -- La the?orie de la continuite? face aux autres the?ories immunologiques -- Qu'est-ce qu'un organisme? L'immunite? et l'individualite? de l'organisme -- L'inte?rieur et l'exte?rieur : l'apport de l'immunologie a? la the?se co-constructionniste -- Conclusion ge?ne?rale. 330 $aQuel est le lien entre immunologie et identité ? Au c?ur de l?immunologie se trouvent les concepts de « soi » et de « non-soi », ainsi que ceux d?unicité et d?individualité. Les immunologistes contemporains affirment que, en se fondant sur le vocabulaire du soi et du non-soi, leur discipline apporte une réponse à la question de savoir ce qui fait l?identité d?un organisme à travers le temps. Cet ouvrage met en doute cette affirmation. S?appuyant sur des données récentes sur la tolérance immunitaire, le chimérisme ou encore la symbiose, il montre que la théorie du soi et du non-soi, qui domine l?immunologie depuis plus de cinquante ans, n?est plus adéquate. Il propose une autre théorie, la théorie de la continuité, dont l?un des objectifs est de rendre compte des nombreux cas dans lesquels un organisme tolère des entités étrangères, en particulier des bactéries. L?organisme doit alors être compris selon une perspective écologique : il est ouvert à l?extériorité, à l?autre, et en grande partie constitué par l?appropriation d?entités initialement « étrangères ». L?immunologie donne bien une définition de l?identité biologique, mais celle-ci est aux antipodes de la conception selon laquelle l?organisme serait une réalité fermée, définie de façon endogène et défendant son intégrité contre tout « non-soi ». 410 0$aCollection Analytiques ;$v18. 606 $aImmunospecificity 606 $aImmunology 606 $aImmunity 610 $aorganisme 610 $aimmunité 610 $aimmunologie 610 $aphilosophie du vivant 615 0$aImmunospecificity. 615 0$aImmunology. 615 0$aImmunity. 676 $a571.9/6 700 $aPradeu$b Thomas$0956726 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910252741803321 996 $aLes limites du soi$92166734 997 $aUNINA LEADER 05401oam 2200505I 450 001 9910793456503321 005 20230817192120.0 010 $a1-351-36694-7 010 $a1-351-36695-5 010 $a1-315-15063-8 024 7 $a10.1201/b22453 035 $a(CKB)4100000007804850 035 $a(MiAaPQ)EBC5725887 035 $a(OCoLC)1089729247 035 $a(OCoLC-P)1089729247 035 $a(FlBoTFG)9781315150635 035 $a(EXLCZ)994100000007804850 100 $a20190312d2019 uy 0 101 0 $aeng 135 $aurcnu---unuuu 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aImmunology $ean introductory textbook /$fedited by Anil K. Sharma 210 1$aSingapore :$cPan Stanford Publishing,$d2019. 215 $a1 online resource (261 pages) 311 $a981-4774-51-0 327 $aCover; Half Title; Title Page; Copyright Page; Table of Contents; Preface; 1: Introduction to lmmunology; 1.1 Historical Attributes; 1.2 lmmunological Responses and Effectors; 1.2.1 lnnate and Adaptive lmmunity; 1.2.1.1 lnnate immunity; 1.2.1.2 Adaptive immunity; 1.3 Summary; 2: lmmunity; 2.1 Basic Concept of lmmunity; 2.2 Historical Background of Immune Responses; 2.3 Cell-Mediated Immune Responses; 2.4 Processing of Endogenous Antigens: Cytosolic Pathway; 2.5 Processing of Endogenous Antigens: Endocytic Pathway; 2.6 Humoral Immunity; 2.7 Activation of B-Cells 327 $a2.8 Humoral Response to T-Dependent Antigens2.9 Humoral Response to T-lndependent Antigens; 3: Proteins of the Immune System; 3.1 Antimicrobial Peptide; 3.2 Pattern Recognition Receptor; 3.3 Toll-Like Receptors; 3.4 NOD Protein; 3.5 Acute Phase Proteins; 3.6 Interferon; 3.7 Complement System; 3.7.1 Function of Complement System; 3.7.2 Complement Nomenclature; 3.8 Activation of Complement Pathways; 3.9 Classical Pathway of the Complement System; 3.10 Lectin Pathway; 3.11 Alternative Pathway; 3.12 Small Fragments of the Complement Protein Initiates Local Inflammatory Response 327 $a3.13 Membrane Attack Complex (MAC) or Lytic Pathway3.14 Regulation of Complement Protein; 3.15 Summary; 4: Major Histocompatibility Complex (MHC): Recent Trends and Relevance from lmmunological Perspective; 4.1 Introduction; 4.2 Nomenclature of HLA Antigens; 4.3 Frequency of Different HLA Alleles; 4.4 Molecular and Genetics Basis of MHC Polymorphisms; 4.4.1 Inheritance; 4.4.2 Expression; 4.5 MHC Molecules: Structure and Genetics; 4.5.1 MHC Class I vs. MHC Class Il; 4.5.1.1 MHC Class I; 4.5.1.2 MHC Class Il; 4.6 Role of MHC in Immune Response; 4.6.1 The Mixed Lymphocyte Reaction 327 $a4.6.2 Antigen Processing and Presentation4.6.3 Sorne Points about MHC Class I and Class Il /TCR; 4.7 Antigen Processing and Presentation; 4.8 Langerhans Cells as APC; 4.9 Antigen Processing and Presentation by Class Il (Exogenous/Endocytic) Pathway; 4.10 Antigen Processing and Presentation by Class I (Endogenous/Cytosolic) Pathway; 4.11 Significance of MHC-Peptide Presentation; 4.12 Clonal Selection of T-cells; 4.13 Generation of Cytotoxic T-Cells; 4.14 Immune Response Genes; 4.15 Complement Factor Genes; 4.16 Nonimmunologic Functions of MHC Genes 327 $a4.17 Disease and the Major Histocompatibility Complex5: Immune System of the Brain; 5.1 Introduction; 5.2 Microglia; 5.3 Astrocytes; 5.4 Toll-Like Receptors; 5.5 Pro-lnflammatory Cytokines; 5.6 Summary; 6: An Overview of lmmunodeficiency Disorders; 6.1 Introduction; 6.2 Primary lmmunodeficiency Diseases; 6.3 Classification of Primary lmmunodeficiency; 6.3.1 Severe Combined lmmunodeficiency; 6.3.1.1 X-linked recessive severe combined immunodeficiency; 6.3.1.2 Adenosine deaminase deficiency; 6.3.2 Well-Defined Syndromes with lmmunodeficiency 330 $aImmunology has emerged as a key component of the curricula of graduate and postgraduate courses in biotechnology, microbiology, biochemistry, bioinformatics, and other interdisciplinary fields of biology, including zoology, veterinary science, and medicine. As a basic introductory textbook on one of the fastest-moving and most challenging areas of immunological science, this book contains the most recent information about immunologic mechanisms and their importance, along with various molecular techniques employed in immunology. The short and concise text helps make the structures, processes, and interactions of the immune system easily comprehensible. The book includes chapters on immunoinformatics as well as the immune system of the brain, rarely found in any of the immunology books published so far. Many diverse and interesting aspects of the advances in immunology have also been covered, including tumor immunology and immunodeficiency disorders. The easy-to-understand concepts presented in the textbook make it an ideal companion for learners preparing for competitive and other examinations. Undergraduate, postgraduate, and PhD students, people from the industry and academia, and research scholars will immensely benefit from it. 606 $aImmunology$xResearch 606 $aImmunology$xTechnique 615 0$aImmunology$xResearch. 615 0$aImmunology$xTechnique. 676 $a616.079072 702 $aSharma$b Anil K.$f1980- 801 0$bOCoLC-P 801 1$bOCoLC-P 906 $aBOOK 912 $a9910793456503321 996 $aImmunology$957829 997 $aUNINA