LEADER 05232nam 2200649Ia 450 001 9910146241603321 005 20170809173118.0 010 $a1-280-52052-3 010 $a9786610520527 010 $a3-527-60543-6 010 $a3-527-60238-0 035 $a(CKB)1000000000019330 035 $a(EBL)482326 035 $a(OCoLC)64625120 035 $a(SSID)ssj0000149055 035 $a(PQKBManifestationID)11136657 035 $a(PQKBTitleCode)TC0000149055 035 $a(PQKBWorkID)10237987 035 $a(PQKB)11596085 035 $a(MiAaPQ)EBC482326 035 $a(EXLCZ)991000000000019330 100 $a20040601d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aErythropoietin$b[electronic resource] $eblood, brain and beyond /$fArthur J. Sytkowski 210 $aWeinheim $cWiley-VCH$d2004 215 $a1 online resource (240 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30495-9 320 $aIncludes bibliographical references and index. 327 $aErythropoietin; Preface; Contents; 1 Introduction and History; 1.1 Early Observations; 1.2 Carnot and Deflandre: A Humoral Factor that Stimulates Erythropoiesis; 1.3 Reissmann, Erslev, Jacobson and Stohlman: The Kidney as the Likely Source; 1.4 More Evidence for the Kidney . . . Erythrogenin?; 1.5 Early Assays for Erythropoietin; 1.6 Standardization: What is a "Unit" of Erythropoietin?; 1.7 References; 2 Developmental Biology of Erythropoiesis and Erythropoietin Production; 2.1 Introduction; 2.2 Yolk Sac Hematopoiesis; 2.2.1 The Role of Erythropoietin in Yolk Sac Erythropoiesis 327 $a2.2.2 Genes Essential to Primitive Erythropoiesis2.3 Fetal Liver and Bone Marrow (Definitive) Erythropoiesis; 2.4 Genes Essential for Definitive Erythropoiesis; 2.5 Erythropoietin Production; 2.6 References; 3 Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia-dependent Genes; 3.1 The Structure of the Erythropoietin Gene; 3.2 Tissue-specific Expression; 3.3 Mechanism of Hypoxic Regulation - Identification of Transcription Factors and Other Regulatory Proteins; 3.3.1 Is the Oxygen Sensor a Heme Protein? 327 $a3.3.2 The 3 ? Flanking Region of the Erythropoietin Gene Contains Important Regulatory Sequences3.3.3 Identification of the Hypoxia-inducible Factor - Hypoxia Regulates More Than the Erythropoietin Gene; 3.3.4 Other Interacting Proteins and the Regulation of HIF-1; 3.3.5 The von Hippel-Lindau Protein, Proline Hydroxylation and the Oxygen Sensor; 3.3.6 Modulation of HIF-1 Activity by Other Signals; 3.3.7 A Final Word on the Heme Protein Hypothesis; 3.4 References; 4 Physiology and Metabolism of Erythropoietin; 4.1 The Kidney as the Site of Production 327 $a4.2 The Liver as a Site of Erythropoietin Production4.3 Erythropoietin Produced in the Bone Marrow; 4.4 Metabolism and Clearance of Erythropoietin; 4.5 Erythropoietin and the Maternal/Fetal Circulation; 4.6 References; 5 Biochemistry and Protein Structure; 5.1 Naturally Occurring Epo; 5.1.1 Difficulties in Purifying the Hormone; 5.1.2 The Purification of Human Urinary Epo; 5.1.3 Biochemical Properties of Human Urinary Epo; 5.1.4 Some Biochemical Properties of Human Serum Epo; 5.2 Recombinant Human Epo; 5.2.1 Cloning the Human Epo Gene; 5.2.2 Glycosylation of Epo 327 $a5.2.3 Physicochemical Properties of Epo5.3 Structure-activity Relationships; 5.3.1 Antibody Studies; 5.3.2 Mutagenesis Studies; 5.4 The Tertiary Structure of Epo; 5.5 References; 6 Receptor Biology and Signal Transduction; 6.1 Receptor Biology; 6.1.1 Identification of the Erythropoietin Receptor; 6.1.2 The Erythropoietin Receptor Gene; 6.1.3 The Structure of the Erythropoietin Receptor: A Member of the Cytokine Receptor Superfamily; 6.1.4 The Extracellular Portion of the Erythropoietin Receptor; 6.1.5 The Cytoplasmic Portion of the Erythropoietin Receptor; 6.2 Signal Transduction Pathways 327 $a6.2.1 Phosphorylation of the Erythropoietin Receptor 330 $aThe use of Epo in medical practice is increasing constantly. It has revolutionized how we think of blood transfusion in medicine and surgery. Moreover, it has become widely known to scientists, physicians, biotech and pharmaceutical executives and the general public. Additionally, the past ten years have seen important advances in our knowledge and understanding of its action both within and outside of the hematopoietic system. Until now, there has been no single source that contains up-to-date information on Epo addressing the array of subjects that this book presents. The boo 606 $aErythropoietin 606 $aErythropoietin$xPhysiological effect 606 $aErythropoietin$xTherapeutic use 608 $aElectronic books. 615 0$aErythropoietin. 615 0$aErythropoietin$xPhysiological effect. 615 0$aErythropoietin$xTherapeutic use. 676 $a612.111 676 $a615.39 700 $aSytkowski$b Arthur J$0875537 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910146241603321 996 $aErythropoietin$91954864 997 $aUNINA LEADER 02074nam 2200469 450 001 9910793390903321 005 20230126220625.0 010 $a1-4985-7357-6 035 $a(CKB)4100000007122843 035 $a(MiAaPQ)EBC5570881 035 $a(EXLCZ)994100000007122843 100 $a20181219d2018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCustomized forms of Kurdishness in Turkey $estate rhetoric, locality, and language use /$fCeren S?engu?l 210 1$aLanham, Maryland :$cLexington Books,$d[2018] 210 4$dİ2018 215 $a1 online resource (137 pages) 225 0 $aKurdish societies, politics, and international relations 311 $a1-4985-7356-8 320 $aIncludes bibliographical references and index. 327 $aIntroduction : researching Kurdishness in Turkey -- Abbreviations -- Two "moments of transition" : how state rhetoric plays a role in manifestations of Kurdishness -- Contextualising Kurdishness through localities : everyday experiences of prejudice/discrimination -- Contextualising Kurdishness through language : family environment and neighbourhood -- Conclusion : (re-)shaping Kurdishness from macro to micro -- Appendix : list of the respondents. 330 $aThis book unpacks the diversity of experiences of Kurdishness in Turkey. By doing that, this book fills the gap within the literature on ethnicities. 606 $aKurds$zTurkey$xPolitics and government 606 $aKurds$zTurkey$xSocial conditions 606 $aKurds$zTurkey$xLanguages 607 $aTurkey$xEthnic relations 615 0$aKurds$xPolitics and government. 615 0$aKurds$xSocial conditions. 615 0$aKurds$xLanguages. 676 $a305.891/5970561 700 $aS?engu?l$b Ceren$01505574 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910793390903321 996 $aCustomized forms of Kurdishness in Turkey$93735208 997 $aUNINA LEADER 03927nam 2200613 450 001 9910822441203321 005 20220505224027.0 010 $a1-5015-0701-X 024 7 $a10.1515/9781501507083 035 $a(CKB)4100000001502385 035 $a(DE-B1597)482335 035 $a(OCoLC)1024017298 035 $a(DE-B1597)9781501507083 035 $a(Au-PeEL)EBL5157610 035 $a(CaPaEBR)ebr11497590 035 $a(OCoLC)1020026692 035 $a(CaSebORM)9781501507014 035 $a(MiAaPQ)EBC5157610 035 $a(EXLCZ)994100000001502385 100 $a20180206h20182018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aNavigating your way to startup success /$fHarlan T Beverly 210 1$aBerlin, [Germany] ;$aBoston, [Massachusetts] :$cDe G Press,$d2018. 210 4$dİ2018 215 $a1 online resource (306 pages) $cillustrations, tables 300 $aIncludes index. 311 $a1-5015-1566-7 311 $a1-5015-0708-7 327 $tFrontmatter --$tAcknowledgments --$tAbout the Author --$tContents --$tChapter 1. Introduction-Why do you want to launch a startup, anyway? --$tChapter 2. Failing to Start-What's stopping you? --$tChapter 3. Your Idea Sucks-How would you know? --$tChapter 4. Failing to Ship-Again, what's stopping you? --$tChapter 5. Nobody Cares-What can you do about it? --$tChapter 6. Somebody Cares-Yippee! Now what? --$tChapter 7. Oops, We Ran Out of Money-Funding and finance --$tChapter 8. I Got Sued-It can happen to you --$tChapter 9. Help, I'm Sinking-Controlling growth --$tChapter 10. The Press Hates Me-Bad reviews --$tChapter 11. I'm Bankrupt-Saving costs and finding profits --$tChapter 12. I Got Fired and I'm the Founder-How? --$tChapter 13. Sold!-Now what? --$tIndex 330 $aStart-ups, like sailing vessels, do not travel in straight lines. The wind and the waves of the real world move the ship, and your start-up, in unpredictable ways. This book is designed to give you an analytical set of tools to help you navigate your start-up or corporate innovation through the murky waters of real life. Every business has failures. No business succeeds without some change of plan. Navigating Your Way to Start-up Success will show you how to create a start-up designed to test its assumptions so those that are not worthy fail-often and fast. This book builds on modern start-up management techniques like Agile and Lean to bring an analytical and quantitative framework to the most common start-up failures. Navigating through those failures means finding your way to start-up success. Harlan T Beverly, PhD holds a BS in Electrical and Computer Engineering, an MBA from UT Austin, and a PhD in Business from Oklahoma State University. Harlan teaches entrepreneurship at the University of Texas at Austin. He is also Assistant Director of the Jon Brumley Texas Venture Labs at UT Austin, the world's first university business accelerator. Harlan has successfully launched five hardware and 15 software products including the Killer NIC, 2007 Network Product of the Year (CPU Magazine). He has raised over$30 million in venture financing in the challenging intersection of entertainment and technology. 606 $aSuccess in business 606 $aNew business enterprises 610 $aEntrepreneur. 610 $aFail fast. 610 $aFounder. 610 $aLean startup. 610 $aProject management. 610 $aSmall business management. 610 $aStartup. 615 0$aSuccess in business. 615 0$aNew business enterprises. 676 $a658.11 700 $aBeverly$b Harlan T.$f1976-$01680793 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910822441203321 996 $aNavigating your way to startup success$94049754 997 $aUNINA LEADER 05598nam 2201417z- 450 001 9910557545103321 005 20210501 035 $a(CKB)5400000000044156 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69140 035 $a(oapen)doab69140 035 $a(EXLCZ)995400000000044156 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aYeast Biotechnology 3.0 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (240 p.) 311 08$a3-03943-186-2 311 08$a3-03943-187-0 330 $aYeasts are truly fascinating microorganisms. Due to their diverse and dynamic activities, they have been used for the production of many interesting products, such as beer, wine, bread, biofuels and biopharmaceuticals. Saccharomyces cerevisiae (bakers' yeast) is the yeast species that is surely the most exploited by man. Saccharomyces is a top choice organism for industrial applications, although its use for producing beer dates back to at least the 6th millennium BC. Bakers' yeast has been a cornerstone of modern biotechnology, enabling the development of efficient production processes for antibiotics, biopharmaceuticals, technical enzymes, and ethanol and biofuels. Today, diverse yeast species are explored for industrial applications, such as e.g. Saccharomyces species, Pichia pastoris and other Pichia species, Kluyveromyces marxianus, Hansenula polymorpha, Yarrowia lipolytica, Candida species, Phaffia rhodozyma, wild yeasts for beer brewing, etc. This Special Issue is focused on recent developments of yeast biotechnology with topics including recent techniques for characterizing yeast and their physiology (including omics and nanobiotechnology techniques), methods to adapt industrial strains (including metabolic, synthetic and evolutionary engineering) and the use of yeasts as microbial cell factories to produce biopharmaceuticals, enzymes, alcohols, organic acids, flavours and fine chemicals, and advances in yeast fermentation technology and industrial fermentation processes. 606 $aTechnology: general issues$2bicssc 610 $aadaptive laboratory evolution (ALE) 610 $aadhesion 610 $aAlcoholic fermentation 610 $aantioxidant 610 $aaroma profile 610 $aAroma profile 610 $aaroma profiling 610 $aatomic force microscope (AFM) 610 $abeer 610 $abeer fermentation 610 $abioethanol production 610 $abiofuel 610 $abioreactors 610 $abrewing 610 $aCandida albicans 610 $acell printing 610 $aco-inoculation 610 $acoffee 610 $acoffee bean fermentation 610 $acoffee beverage 610 $acoffee fermentation 610 $acoffee processing 610 $acolor pigments 610 $acraft beer 610 $aCRISPR-Cas9 610 $aCyberlindnera 610 $adynamic single-cell analysis 610 $afederweisser 610 $afermentation 610 $afermentation-derived products 610 $afermented beverages 610 $afibronectin 610 $aflavor 610 $aflavor compounds 610 $agas chromatography 610 $agenetic engineering 610 $aGFP-tagged yeast clone collection 610 $aglycerol transport 610 $agrape 610 $ahyperosmotic stress 610 $aIcewine 610 $aindustrial brewer's strains 610 $aitaconic acid 610 $aitaconic acid production 610 $alactic acid bacteria 610 $alignocellulosic feedstock 610 $aliving cell microarrays 610 $aMALDI-TOF MS Biotyper 610 $aMalolactic fermentation 610 $aMetschnikowia pulcherrima 610 $amicrobiota identification 610 $amicrobrewery plant 610 $amicrofluidic chip 610 $amixed fermentation 610 $aNABLAB 610 $ananomotion 610 $anon-alcoholic beer 610 $anon-conventional yeast 610 $anon-Saccharomyces yeast 610 $anon-Saccharomyces yeasts 610 $aOenococcus oeni 610 $aOmegaTM 610 $aPichia stipitis 610 $apiezoelectric dispensing 610 $aPN4TM 610 $aprocess improvement 610 $aproton-transfer reaction-mass spectrometry 610 $aresponse surface methodology 610 $aSacccharomyces cerevisiae 610 $aSaccharomyces 610 $aSaccharomyces cerevisiae 610 $asequence inoculation 610 $aSimultaneous inoculation 610 $asnowflake phenotype 610 $aSpathaspora passalidarum 610 $astarter culture 610 $aSTL1 610 $astrain collection 610 $aTorulaspora delbrueckii 610 $aUstilago 610 $avolatile aroma compounds 610 $avolatile organic compounds 610 $aW. anomalus 610 $awine 610 $awine yeast 610 $awine yeasts 610 $axylose metabolism 610 $ayeast 610 $ayeast micro- and nanobiotechnology 610 $ayeasts 615 7$aTechnology: general issues 700 $aWillaert$b Ronnie G$4edt$01312122 702 $aWillaert$b Ronnie G$4oth 906 $aBOOK 912 $a9910557545103321 996 $aYeast Biotechnology 3.0$93030715 997 $aUNINA