LEADER 05331nam 2200637Ia 450 001 9910792418603321 005 20230725023303.0 010 $a1-282-54809-3 010 $a9786612548093 010 $a0-470-68657-X 035 $a(CKB)2670000000014763 035 $a(EBL)514434 035 $a(OCoLC)609862929 035 $a(SSID)ssj0000357654 035 $a(PQKBManifestationID)11272687 035 $a(PQKBTitleCode)TC0000357654 035 $a(PQKBWorkID)10354250 035 $a(PQKB)11406056 035 $a(MiAaPQ)EBC514434 035 $a(Au-PeEL)EBL514434 035 $a(CaPaEBR)ebr10377854 035 $a(CaONFJC)MIL254809 035 $a(EXLCZ)992670000000014763 100 $a20091124d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCell death$b[electronic resource] /$feditors, Gerry Melino, David Vaux 210 $aChichester, West Sussex ;$aHoboken, NJ $cJohn Wiley & Sons$d2010 215 $a1 online resource (317 p.) 300 $aDescription based upon print version of record. 311 $a0-470-71573-1 320 $aIncludes bibliographical references and index. 327 $aCover; Cell Death; Copyright Page; Contents; Contributors; Preface; The Siren's Song: This Death That Makes Life Live; References; Further Reading; The Origin and Evolution of Programmed Cell Death; Introduction; Origins: From the Question 'When' to the Question 'How'; From Predator/Prey Coevolution to Symbioses: A 'Red Queen' Hypothesis in the Bacteria World; A Stable Evolutionary Strategy despite High Individual Costs; The 'Original Sin' Hypothesis: Self-destruction as an Unavoidable Consequence of Life; C. elegans Model: From Paradigm to Paradox; Walking Around the Evolutionary Bush 327 $aFrom the Origins of Programmed Cell Death to the Origins of Ageing'There is Grandeur in This View of Life...'; References; Further Reading; Cell Death in C. elegans; ced-3, ced-4, ced-9 and egl-1 are Conserved Genes Essential for Programmed Cell Death in C. elegans; Regulation of Cell Death during Somatic Development; Engulfment of Dying Cells; Germline Apoptosis; DNA Damage-induced Germline Apoptosis; Conclusion; References; Further Reading; Caspases and Cell Death; History and Classification; Structure and Active Site; Substrate Recognition and Mechanism of Action; Sequence of Action 327 $aSubstrates during ApoptosisInhibitors; Caspase Knockouts; Pathological Implications; Therapeutic Outlook; References; Further Reading; The Apoptosome: The Executioner of Mitochondria-mediated Apoptosis; Introduction; The Apoptosome Structure: Its Components and Its Assembly; Apaf1; Apoptosome assembly; Caspase-9; Cytochrome c; Modulation of the Apoptosome Formation; Apoptosome-like Complexes in Evolution. Is the Mitochondrial Pathway of Apoptosis Conserved?; Caenorhabditis elegans; Drosophila melanogaster; The Role of the Apoptosome in Mammalian Development; Caspase-9 knockout; Apaf1 knockout 327 $aCytochrome c deficiencyFinal Remarks; References; Further Reading; Caspases, Substrates and Sequential Activation; Introduction; Caspases Classification and Structure; Pathways That Lead to Caspase Activation; Extrinsic pathway; Granzyme B pathway; Intrinsic pathway; Effectors of demolition; Demolition Phase of Apoptosis; Detachment, rounding and blebbing; Nuclear fragmentation, DNA condensation and degradation; Undermining cell physiology; Immune Clearance and Immune Tolerance of Apoptotic Cells; Conclusions; Acknowledgements; References; Further Reading; Dismantling the Apoptotic Cell 327 $aIntroductionCaspases: Regulators of the Apoptotic Process; Activation of the apoptotic caspases; Effect of caspase-mediated cleavage on target substrates - gain- or loss-of-function; Cleavage of caspase substrates leads to key morphological changes during apoptosis; Cytoskeletal events and membrane blebbing; Nuclear events; Changes in the Golgi apparatus; Caspases alter the transcriptional and translational machinery; Survival pathways are targeted during apoptosis; The apoptotic cell calls for its own disposal; Caspase-independent cell death; Concluding Remarks; References; Further Reading 327 $aThe BCL-2 Family Proteins - Key Regulators and Effectors of Apoptosis 330 $aThis book on cell death contains 29 self-contained, peer-reviewed articles written by leading scientists in each field. It features overview articles aimed at undergraduates and non-specialists, which present basic information and provide entry into the following advanced articles. These advanced articles are written for postgraduate students and research workers, containing detailed information and key references allowing the reader to investigate a specific area in more depth. The book is an essential resource for educational purposes as well as a reference work for experienced researchers i 606 $aApoptosis 606 $aCell death 615 0$aApoptosis. 615 0$aCell death. 676 $a571.9/36 701 $aMelino$b Gerry$01562609 701 $aVaux$b David$01562610 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910792418603321 996 $aCell death$93830403 997 $aUNINA