LEADER 03408nam 22005652 450 001 9910792125203321 005 20151005020622.0 010 $a0-511-84765-3 010 $a1-107-20737-1 010 $a0-511-64185-0 010 $a0-511-63941-4 010 $a0-511-64049-8 010 $a0-511-63834-5 010 $a0-511-64236-9 035 $a(CKB)2610000000005671 035 $a(MiAaPQ)EBC3004564 035 $a(Au-PeEL)EBL3004564 035 $a(CaPaEBR)ebr10356365 035 $a(CaONFJC)MIL238668 035 $a(OCoLC)593222021 035 $a(UkCbUP)CR9780511642364 035 $a(EXLCZ)992610000000005671 100 $a20091012d2010|||| uy| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGene transfer and the ethics of first-in-human research $elost in translation /$fJonathan Kimmelman$b[electronic resource] 210 1$aCambridge :$cCambridge University Press,$d2010. 215 $a1 online resource (xi, 205 pages) $cdigital, PDF file(s) 300 $aTitle from publisher's bibliographic system (viewed on 05 Oct 2015). 311 $a0-521-69084-6 311 $a0-521-87059-3 320 $aIncludes bibliographical references and index. 327 $aIntroduction: gene transfer lost in translation -- What is gene transfer? -- Safety, values, and legitimacy: the protean nature of risk in translational trials -- Taming uncertainty: risk and gene-transfer clinical research -- Succor or suckers? Benefit, risk, and the therapeutic misconception -- Looking backward: a model value for translational trials -- The chasm: the ethics of initiating first-in-human clinical trials -- Tropic of cancers: gene transfer in resource-poor settings -- Great expectations and hard times: expectation management in gene transfer -- Something in the sight adjusts itself: conclusions. 330 $aHuman gene transfer is widely regarded as one of the most promising technologies for the treatment of a variety of disorders, but it presents practitioners with a variety of difficult ethical questions. Gene Transfer and the Ethics of First-in-Human Research examines the ethical and policy dimensions of testing interventions in human beings for the first time. The book discusses the difficult ethical challenges that arise from attempting to translate laboratory discoveries into clinical applications. These range from which available techniques to use, when to initiate human testing, questions of consent, expectation in public arenas, how to define acceptable risk, and the inclusion of vulnerable or disadvantaged subjects in early phase trials. This book is relevant to ethicists, legal practitioners, policy makers, geneticists and clinicians involved in clinical trials of new medical interventions. 517 3 $aGene Transfer & the Ethics of First-in-Human Research 606 $aGene therapy$xMoral and ethical aspects 606 $aClinical trials$xMoral and ethical aspects 615 0$aGene therapy$xMoral and ethical aspects. 615 0$aClinical trials$xMoral and ethical aspects. 676 $a615.8/95 700 $aKimmelman$b Jonathan$01518421 801 0$bUkCbUP 801 1$bUkCbUP 906 $aBOOK 912 $a9910792125203321 996 $aGene transfer and the ethics of first-in-human research$93756008 997 $aUNINA LEADER 04054nam 2200661Ia 450 001 9910957997703321 005 20200520144314.0 010 $a9786610932993 010 $a9780871205438 010 $a0871205432 010 $a9781416601791 010 $a1416601791 010 $a9781280932991 010 $a1280932996 035 $a(CKB)1000000000242029 035 $a(MiAaPQ)EBC280292 035 $a(MiAaPQ)EBC3002105 035 $a(MiAaPQ)EBC4948033 035 $a(Au-PeEL)EBL3002105 035 $a(CaPaEBR)ebr10070399 035 $a(OCoLC)57225166 035 $a(Au-PeEL)EBL4948033 035 $a(CaONFJC)MIL93299 035 $a(Perlego)3292548 035 $a(EXLCZ)991000000000242029 100 $a19991013d2000 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBecoming a multiple intelligences school /$fThomas R. Hoerr 205 $a1st ed. 210 $aAlexandria, Va. $cAssociation for Supervision and Curriculum Development$dc2000 215 $axii, 113 p. $cill 300 $a"ASCD Stock No. 100006"--T.p. verso. 311 08$a9780871203656 311 08$a0871203650 311 08$a9781416601784 311 08$a1416601783 320 $aIncludes bibliographical references (p. 107) and index. 327 $aThe theory of multiple intelligences -- The New City School journey -- Collegiality : learning and growing together -- Assessing and reporting student growth -- Creative routes to MI -- The importance of the personal intelligences -- The phases of MI implementation -- Supporting teacher growth with leadership -- What's next? : the future of MI. 330 $aIn this invaluable book, Tom Hoerr relates a decade's worth of MI experiences at St. Louis's New City School. We learn about the staff's initial exposure to MI theory, the many activities (some more successful than others) that were undertaken by faculty and staff in teaching, curriculum, adult development, and assessment; the challenges that the leader faces in attempting to bring about significant and lasting change. Especially compelling are the continuing efforts to develop the personal intelligences during a period when issues of diversity, multiculturalism, and standards loom so large.Hoerr underscores the centrality of collegiality, the problems posed by transient students and faculty, the complimentary role played by public exhibitions and standardized test scores, the role of friends in determining the activities (and intelligences) favored by the children the delicate line between support and challenge that the leader must walk, the tension between excellence and perfection. I value the concrete examples, as well as the ties to important conceptual work, such as that undertaken by Roland Barth on collegiality, Peter Salovey on emotional intelligence, and Peter Senge on the learning organization.Achieving excellence has always been a process. Hoerr makes it abundantly clear that the effort to use MI ideas effectively must remain on the agenda. Still, I can testify that, over a 10-year period, clear, palpable, impressive progress can be made. We can improve schools significantly, but only if we take the long view and do not settle for patch work fixes.Thomas R. Hoerr is the director of the New City School in St. Louis, Missouri. Under Hoerr's leadership, the faculty began implementing the theory of multiple intelligences in 1988. 606 $aMultiple intelligences$vCase studies 606 $aCognitive styles in children$vCase studies 606 $aCurriculum planning$vCase studies 615 0$aMultiple intelligences 615 0$aCognitive styles in children 615 0$aCurriculum planning 676 $a370.15/2 700 $aHoerr$b Thomas R.$f1945-$01105310 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910957997703321 996 $aBecoming a multiple intelligences school$94355659 997 $aUNINA