LEADER 05267nam 2200637Ia 450 001 9910792083903321 005 20230802012850.0 010 $a1-283-59367-X 010 $a9786613906120 010 $a981-4335-36-3 035 $a(CKB)2560000000093358 035 $a(EBL)1019615 035 $a(OCoLC)811504359 035 $a(SSID)ssj0000703137 035 $a(PQKBManifestationID)12332966 035 $a(PQKBTitleCode)TC0000703137 035 $a(PQKBWorkID)10686985 035 $a(PQKB)10482495 035 $a(MiAaPQ)EBC1019615 035 $a(WSP)00008032 035 $a(Au-PeEL)EBL1019615 035 $a(CaPaEBR)ebr10596912 035 $a(CaONFJC)MIL390612 035 $a(EXLCZ)992560000000093358 100 $a20120112d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe MIF handbook$b[electronic resource] /$fedited by Richard Bucala 210 $aHackensack, NJ. $cWorld Scientific$dc2012 215 $a1 online resource (399 p.) 300 $aDescription based upon print version of record. 311 $a981-4335-35-5 320 $aIncludes bibliographical references and index. 327 $aContents; Preface; Part I MIF Structure and Mechanism of Action; I-1 MIF, MIF Alleles, and the Regulation of the Host Response Richard Bucala; 1. Introduction; 2. MIF Gene; 3. MIF Production and Signal Transduction; 4. Innate Immunity; 5. Adaptive Immunity; 6. MIF Integrates Immune, Metabolic, and Oncogenic Responses; 7. MIF Alleles in Human Disease; 8. Therapeutic Implications and Future Directions; Acknowledgments; References; I-2 MIF and the Chemokine Axis Sandra Kraemer, Christian Weber and Ju?rgen Bernhagen; 1. Introduction; 2. Chemokines: Classes, Structure, Function, and Receptors 327 $a3. Structural Classification of MIF4. Nonclassical MIF Secretion and Link to Secretion of CLF Chemokines; 5. Chemokine-like Function (CLF) Chemokines and MIF as a CLF Chemokine; 6. MIF/ Chemokine Receptor Interactions and Functional Role in Inflammation and Atherogenesis; 7. Structural Basis Underlying MIF/Chemokine Receptor Interactions; 8. MIF Receptor Complexes; 9. Conclusion; 10. Acknowledgments; References; I-3 CD74, the Natural Receptor for MIF, Regulates Cell Survival in Health and Disease Idit Shachar, Maya Gordin, Sivan Cohen, Inbal Binsky, Ayelet Marom and Shirly Becker-Herman 327 $a1. Introduction2. CD74 (Invariant Chain, Ii); 3. CD74 Functions as a Chaperone for MHC Class II; 4. CD74 as a Signaling Molecule; 4.1 CD74 is a cell surface receptor that induces signaling cascades; 4.2 CD74 is subjected to regulated intramembrane proteolysis (RIP); 5. MIF Regulates B Cell Survival in a CD74-Dependent Manner; 5.1 A complex of CD74 and CD44 is essential for initiating the signaling cascade induced by MIF; 5.2 c-Met and its ligand HGF regulate mature B cell survival in a pathway induced by MIF binding to CD74/CD44 327 $a5.3 MIF induces TAp63 expression, which regulates B cell survival in a CD74-dependent manner6. MIF Is Secreted from Perivascular Bone Marrow Dendritic Cell Clusters that Regulate B Cell Survival; 7. MIF and CD74 in Tumors; 7.1 MIF and CD74 in CLL survival; 7.2 MIF and CD74 regulate CLL homing to the BM; References; I-4 Towards the MIF Interactome Jo?rg Klug and Andreas Meinhardt; 1. Introduction; 2. MIF Affects Degradation of Regulatory Proteins by Modulating the Ubiquitin Proteasome System; 3. Ribosomal Protein S19 as Endogenous Inhibitor of Extracellular MIF 327 $a4. Interactors Involved in MIF Redox Activity4.1. Insulin; 4.2. Hepatopoietin (HPO); 4.3. Proliferation-associated gene (PAG) protein; 4.4. p53; 4.5. Protein (NM23A) expressed in nonmetastatic cells (NM23-H1); 4.6. ?1-inhibitor-3 (?1-I3); 5 Concluding Remarks; Acknowledgments; References; I-5 Structural Studies of Small Molecule Inhibitors of MIF Yoonsang Cho and Elias J. Lolis; 1. Introduction; 2. Small Molecule Structures; 3. Catalytic Site Inhibitors; 4. Covalent Inhibitors; 5. Allosteric and Mixed Inhibitors; References; Part II Regulation of MIF Expression 327 $aII-1 Epigenetic Control of MIF Expression Thierry Roger, Je?ro?me Lugrin, Xavier C. Ding and Thierry Calandra 330 $aThe role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development.Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and 606 $aCytokines 606 $aImmune response$xRegulation 615 0$aCytokines. 615 0$aImmune response$xRegulation. 676 $a572/.696 701 $aBucala$b Richard$098986 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910792083903321 996 $aThe MIF handbook$93758396 997 $aUNINA