LEADER 04774nam 2200637Ia 450 001 9910791833303321 005 20200520144314.0 010 $a1-61761-663-X 035 $a(CKB)2560000000067933 035 $a(EBL)3017942 035 $a(SSID)ssj0000418529 035 $a(PQKBManifestationID)12110292 035 $a(PQKBTitleCode)TC0000418529 035 $a(PQKBWorkID)10377006 035 $a(PQKB)11676927 035 $a(MiAaPQ)EBC3017942 035 $a(Au-PeEL)EBL3017942 035 $a(CaPaEBR)ebr10654913 035 $a(OCoLC)923654443 035 $a(EXLCZ)992560000000067933 100 $a20090930d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGenome instability and transgenerational effects$b[electronic resource] /$fIgor Kovalchuk and Olga Kovalchuk, editors 210 $aNew York $cNova Science Publishers$dc2010 215 $a1 online resource (490 p.) 225 0$aGenetics--research and issues series 300 $aDescription based upon print version of record. 311 $a1-60876-831-7 320 $aIncludes bibliographical references and index. 327 $a""GENOME INSTABILITY AND TRANSGENERATIONAL EFFECTS""; ""GENOME INSTABILITY AND TRANSGENERATIONAL EFFECTS""; ""CONTENTS ""; ""PREFACE ""; ""GENETIC AND EPIGENETIC REGULATION OF TRANSGENERATIONAL CHANGES IN GENOME STABILITY: AN OVERVIEW""; ""REFERENCES ""; ""GENETIC AND EPIGENETIC MECHANISMS ENSURING STABILITY OF MAMMALIAN GENOMES""; ""ABSTRACT ""; ""INTRODUCTION ""; ""GENETIC MECHANISMS OF GENOME STABILITY ""; ""Direct Reversal of Damage ""; ""Base Excision Repair ""; ""Nucleotide Excision Repair ""; ""Mismatch Repair ""; ""Repair of DNA Strand Breaks by Homologous Recombination "" 327 $a""Non-Homologous End Joining """"Cell Cycle Checkpoints ""; ""EPIGENETIC REGULATION OF GENOMIC STABILITY ""; ""DNA Methylation ""; ""Histone Modifications ""; ""Short RNA-Mediated Silencing ""; ""CONCLUSION ""; ""REFERENCES ""; ""GENETIC AND EPIGENETIC REGULATION OF GENOME STABILITY IN PLANTS""; ""ABSTRACT ""; ""INTRODUCTION ""; ""1. ENDOGENOUS AND EXOGENOUS FACTORS THAT AFFECT GENOME STABILITY""; ""1.1. Reactive Oxygen Species Challenge DNA the Repair Machinery and Decrease Genome Stability ""; ""1.2. The Choice of DNA Repair Pathway May Regulate Plant Genome Stability "" 327 $a""1.3. The Importance of Plant Genome Plasticity for Stress Tolerance and Genome Evolution""""2. MECHANISMS AND FUNCTIONS OF EPIGENETIC REGULATIONS IN THE PLANT GENOME ""; ""2.1. DNA Methylation Is a Critical Component in the System of Epigenetic Modifications in Plants""; ""2.2. Histone Modifications and DNA Methylation Are Interdependent ""; ""2.3. Chromatin Remodeling Shapes Chromatin Structure and Complements DNA and Histone Modifications""; ""3. EPIGENETIC MODIFICATIONS a??? A STRESS-RESPONSIVE MECHANISM CONTROLLING GENE REGULATION AND GENOME STABILITY"" 327 $a""3.1. Effects of Stress on Epigenetic Regulations """"3.2. Small RNAs May Direct Epigenetic Modifications to a Specific Genomic Locus""; ""3.2.1. The Complexity and Functional Redundancy of smRNA Biogenesis Pathways in Arabidopsis ""; ""3.2.2. Mechanisms of smRNA-Directed Epigenetic Regulations ""; ""3.2.3. Small RNA Biogenesis is a Sensitive Stress-Responsive System ""; ""4. INDUCIBLE EPIGENETIC CHANGES MAY CHANGE GENOME STABILITY AND GUIDE GENOME EVOLUTION""; ""CONCLUDING REMARKS ""; ""ACKNOWLEDGMENTS ""; ""REFERENCES ""; ""EVOLUTION OF THE FPG/NEI FAMILY OF DNA GLYCOSYLASES "" 327 $a""ABSTRACT """"ABBREVIATIONS ""; ""INTRODUCTION ""; ""METHODS ""; ""EVENTS IN THE FPG/NEI PHYLOGENY ""; ""Horizontal Transfer ""; ""Changes in Substrate Specificity ""; ""Changes in the Structural Zinc-Finger Motif ""; ""Expansion within the Actinobacteria ""; ""THE ENZYMATIC FUNCTION OF THE FPG2 GLADE REMAINS UNKNOWN ""; ""CONCLUSION ""; ""REFERENCES ""; ""STRESS-INDUCED MUTAGENESIS IN BACTERIA ""; ""ABSTRACT ""; ""INTRODUCTION ""; ""STRESSFUL (MUTAGENIC) FACTORS ""; ""STRESS RESPONSE TO ENDOGENOUS AND EXOGENOUS DNA-DAMAGING AGENTS""; ""TRANSLESION DNA SYNTHESIS "" 327 $a""THE GENERAL STRESS RESPONSE "" 410 0$aGenetics - Research and Issues 606 $aEpigenesis 606 $aMutation (Biology) 606 $aVariation (Biology) 615 0$aEpigenesis. 615 0$aMutation (Biology) 615 0$aVariation (Biology) 676 $a572.8/77 701 $aKovalchuk$b Igor$01520211 701 $aKovalchuk$b Olga$cMD.$01520212 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910791833303321 996 $aGenome instability and transgenerational effects$93758757 997 $aUNINA LEADER 02235nam 2200481 450 001 9910812985603321 005 20230807214646.0 010 $a2-8027-5164-6 035 $a(CKB)3790000000018378 035 $a(EBL)2085506 035 $a(MiAaPQ)EBC2085506 035 $a(Au-PeEL)EBL2085506 035 $a(OCoLC)914152198 035 $a(EXLCZ)993790000000018378 100 $a20200120h20152015 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aBoundaries of European private international law $eLes frontie?res du droit international prive? europe?en = Las fronteras del derecho internacional privado europeo /$fJean-Sylvestre Berge?, Ste?phanie Francq, Miguel Garden?es Santiago, editors 210 1$aBruxelles :$cBruylant,$d[2015] 210 4$d©2015 215 $a1 online resource (1090 p.) 300 $aDescription based upon print version of record. 311 $a2-8027-4697-9 320 $aIncludes bibliographical references. 330 $a European private international law is by now based mainly on a large body of uniform rules such as the Regulations Rome I, Rome II, Brussels I, Brussels I bis. 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