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100   $a20090930d2010      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aGenome instability and transgenerational effects$b[electronic resource] /$fIgor Kovalchuk and Olga Kovalchuk, editors
210   $aNew York $cNova Science Publishers$dc2010
215   $a1 online resource (490 p.)
225  0$aGenetics--research and issues series
300   $aDescription based upon print version of record.
311   $a1-60876-831-7 
320   $aIncludes bibliographical references and index.
327   $a""GENOME INSTABILITY AND TRANSGENERATIONAL EFFECTS""; ""GENOME INSTABILITY AND TRANSGENERATIONAL EFFECTS""; ""CONTENTS ""; ""PREFACE ""; ""GENETIC AND EPIGENETIC REGULATION  OF TRANSGENERATIONAL CHANGES  IN GENOME STABILITY: AN OVERVIEW""; ""REFERENCES ""; ""GENETIC AND EPIGENETIC MECHANISMS ENSURING STABILITY OF MAMMALIAN GENOMES""; ""ABSTRACT ""; ""INTRODUCTION ""; ""GENETIC MECHANISMS OF GENOME STABILITY ""; ""Direct Reversal of Damage ""; ""Base Excision Repair ""; ""Nucleotide Excision Repair ""; ""Mismatch Repair ""; ""Repair of DNA Strand Breaks by Homologous Recombination ""
327   $a""Non-Homologous End Joining """"Cell Cycle Checkpoints ""; ""EPIGENETIC REGULATION OF GENOMIC STABILITY ""; ""DNA Methylation ""; ""Histone Modifications ""; ""Short RNA-Mediated Silencing ""; ""CONCLUSION ""; ""REFERENCES ""; ""GENETIC AND EPIGENETIC REGULATION  OF GENOME STABILITY IN PLANTS""; ""ABSTRACT ""; ""INTRODUCTION ""; ""1. ENDOGENOUS AND EXOGENOUS FACTORS THAT AFFECT  GENOME STABILITY""; ""1.1. Reactive Oxygen Species Challenge DNA the Repair Machinery  and Decrease Genome Stability ""; ""1.2. The Choice of DNA Repair Pathway May Regulate Plant Genome Stability ""
327   $a""1.3. The Importance of Plant Genome Plasticity for Stress Tolerance and Genome Evolution""""2. MECHANISMS AND FUNCTIONS OF EPIGENETIC REGULATIONS  IN THE PLANT GENOME ""; ""2.1. DNA Methylation Is a Critical Component in the System of Epigenetic Modifications in Plants""; ""2.2. Histone Modifications and DNA Methylation Are Interdependent ""; ""2.3. Chromatin Remodeling Shapes Chromatin Structure and Complements DNA and Histone Modifications""; ""3. EPIGENETIC MODIFICATIONS a??? A STRESS-RESPONSIVE MECHANISM CONTROLLING GENE REGULATION  AND GENOME STABILITY""
327   $a""3.1. Effects of Stress on Epigenetic Regulations """"3.2. Small RNAs May Direct Epigenetic Modifications to a Specific Genomic Locus""; ""3.2.1. The Complexity and Functional Redundancy of smRNA Biogenesis Pathways in Arabidopsis ""; ""3.2.2. Mechanisms of smRNA-Directed Epigenetic Regulations ""; ""3.2.3. Small RNA Biogenesis is a Sensitive Stress-Responsive System ""; ""4. INDUCIBLE EPIGENETIC CHANGES MAY CHANGE GENOME STABILITY AND GUIDE GENOME EVOLUTION""; ""CONCLUDING REMARKS ""; ""ACKNOWLEDGMENTS ""; ""REFERENCES ""; ""EVOLUTION OF THE FPG/NEI FAMILY OF DNA GLYCOSYLASES ""
327   $a""ABSTRACT """"ABBREVIATIONS ""; ""INTRODUCTION ""; ""METHODS ""; ""EVENTS IN THE FPG/NEI PHYLOGENY ""; ""Horizontal Transfer ""; ""Changes in Substrate Specificity ""; ""Changes in the Structural Zinc-Finger Motif ""; ""Expansion within the Actinobacteria ""; ""THE ENZYMATIC FUNCTION OF THE FPG2 GLADE REMAINS UNKNOWN ""; ""CONCLUSION ""; ""REFERENCES ""; ""STRESS-INDUCED MUTAGENESIS IN BACTERIA ""; ""ABSTRACT ""; ""INTRODUCTION ""; ""STRESSFUL (MUTAGENIC) FACTORS ""; ""STRESS RESPONSE TO ENDOGENOUS AND EXOGENOUS DNA-DAMAGING AGENTS""; ""TRANSLESION DNA SYNTHESIS ""
327   $a""THE GENERAL STRESS RESPONSE ""
410  0$aGenetics - Research and Issues
606   $aEpigenesis
606   $aMutation (Biology)
606   $aVariation (Biology)
615  0$aEpigenesis.
615  0$aMutation (Biology)
615  0$aVariation (Biology)
676   $a572.8/77
701   $aKovalchuk$b Igor$01520211
701   $aKovalchuk$b Olga$cMD.$01520212
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910791833303321
996   $aGenome instability and transgenerational effects$93758757
997   $aUNINA