LEADER 04659nam 2200601Ia 450 001 9910791771703321 005 20230721012907.0 010 $a1-61209-692-1 035 $a(CKB)2560000000069951 035 $a(EBL)3018239 035 $a(SSID)ssj0000469841 035 $a(PQKBManifestationID)11331920 035 $a(PQKBTitleCode)TC0000469841 035 $a(PQKBWorkID)10530861 035 $a(PQKB)11010463 035 $a(MiAaPQ)EBC3018239 035 $a(Au-PeEL)EBL3018239 035 $a(CaPaEBR)ebr10659161 035 $a(OCoLC)923657015 035 $a(EXLCZ)992560000000069951 100 $a20090730d2009 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHandbook on mass spectrometry$b[electronic resource] $einstrumentation, data and analysis, and applications /$fJ.K. Lang, editor 210 $aNew York $cNova Science Publishers$dc2009 215 $a1 online resource (545 p.) 225 0 $aAdvances in chemistry research series 300 $aDescription based upon print version of record. 311 $a1-60741-580-1 320 $aIncludes bibliographical references and index. 327 $a""HANDBOOK ON MASS SPECTROMETRY:INSTRUMENTATION, DATA AND ANALYSIS, AND APPLICATIONS""; ""CONTENTS""; ""PREFACE""; ""MASS SPECTROMETRIC CHARACTERIZATION OF ORGANOMETALLIC COMPOUNDS""; ""ABSTRACT""; ""1. INTRODUCTION""; ""2. IONIZATION TECHNIQUES""; ""3. MASS ANALYZERS""; ""4. BASIC IONIZATION MECHANISMS OF ORGANOMETALLICS""; ""5. MASS SPECTROMETRY OF INDIVIDUAL ORGANOMETALLIC CLASSES""; ""5.1. Main Group Organometallic Compounds""; ""Simple main group organometallic compounds""; ""Organotin compounds""; ""Organolead compounds""; ""Organogermanium compounds"" 327 $a""Organoarsenic, organoantimony and organobismuth compounds""""Organoboron compounds""; ""Organoaluminum, organogallium and organoindium compounds""; ""Organoselenium and organotellurium compounds""; ""Organosilicon compounds""; ""5.2. Transition Metal Organometallic Compounds""; ""Metallocenes and related compounds""; ""Transition metal organometallic compounds containing covalent carbon-metal bond""; ""Heteropolymetallic complexes""; ""5.3. Organometallics Compounds Containing Lanthanoids""; ""6. CONCLUSION""; ""ACKNOWLEDGMENTS""; ""7. REFERENCES""; ""LC-MS BASED METABOLOMICS"" 327 $a""ABSTRACT""""1. METABOLOMICS?""; ""1.1. The Positioning of Metabolomics in Research""; ""1.2. Challenges in Metabolomics Approaches""; ""1.3. Mass Spectrometry in Metabolomics Research""; ""2. STAGES IN AN LC-MS BASED METABOLOMICS ANALYSIS""; ""2.1. Sample Collection and Sample Storage""; ""2.2. Sample Homogenisation/Extraction/Deproteinisation""; ""2.3. Liquid Chromatography (LC)""; ""2.4. The Ionisation Process as an Interface between LC and MS: Focus on Matrix Effect""; ""2.5. Mass Spectrometry""; ""2.6. Data Handling""; ""2.6.1. Data processing""; ""2.6.1.1. Filtering"" 327 $a""2.6.1.2. Feature/peak detection""""2.6.1.3. Alignment""; ""2.6.1.4. Normalisation""; ""2.6.2. Data analysis""; ""2.6.2.1. Principal component analysis (PCA) ""; ""2.6.2.2 Partial least-squares projections to latens structures (PLS)""; ""2.6.2.3. O-PLS""; ""2.7. Metabolite Identification""; ""3. CONCLUSION""; ""REFERENCES""; ""BIOMARKER DISCOVERY FOR CANCER DIAGNOSIS USING SERUM PROTEOMIC ANALYSIS:FROM BASIC RESEARCH TO CLINICAL APPLICATION""; ""ABSTRACT""; ""INTRODUCTION""; ""1. PROTEOMIC ANALYSIS OF SERUM/PLASMA IS EFFECTIVE TO SEARCH FOR CANCER DIAGNOSTIC MARKERS"" 327 $a""1.1. Characteristics of Global Analyses and Diagnostic Availability of Biomarkers""""1.2. Advantages of Proteomic Analysis in the Search for Diagnostic Biomarkers""; ""1.3. Specimen""; ""2. SEPARATION TECHNOLOGIES IN PROTEOMIC ANALYSIS""; ""2.1. 2D-DIGE""; ""2.2. Protein Chip ArrayA?®""; ""2.3. ClinProtA?®""; ""2.4. Shotgun Proteomics Using LC""; ""3. MASS SPECTROMETRY""; ""3.1. Fundamentals of MS""; ""3.2. Ionization Methods""; ""3.3. Mass Analyzers""; ""3.4. Types of MS Used in Proteomic Analysis""; ""4. IDENTIFICATION OF PROTEINS/PEPTIDES USING MS"" 327 $a""4.1. Protein Identification by Peptide Mass Fingerprinting"" 410 0$aAdvances in Chemistry Research 606 $aMass spectrometry 606 $aChemistry, Analytic 615 0$aMass spectrometry. 615 0$aChemistry, Analytic. 676 $a543/.65 701 $aLang$b J. K$01537262 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910791771703321 996 $aHandbook on mass spectrometry$93786453 997 $aUNINA