LEADER 05411nam 2200709Ia 450 001 9910146072403321 005 20230617031200.0 010 $a1-280-25284-7 010 $a9786610252848 010 $a0-470-35525-5 010 $a0-471-67557-1 010 $a0-471-67558-X 035 $a(CKB)1000000000019026 035 $a(EBL)226544 035 $a(OCoLC)80242167 035 $a(SSID)ssj0000159711 035 $a(PQKBManifestationID)11946957 035 $a(PQKBTitleCode)TC0000159711 035 $a(PQKBWorkID)10158802 035 $a(PQKB)10761413 035 $a(MiAaPQ)EBC226544 035 $a(Au-PeEL)EBL226544 035 $a(CaPaEBR)ebr10114132 035 $a(CaONFJC)MIL25284 035 $a(EXLCZ)991000000000019026 100 $a20031215d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFunctional metabolism$b[electronic resource] $eregulation and adaptation /$fedited by Kenneth B. Storey 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2004 215 $a1 online resource (614 p.) 300 $aDescription based upon print version of record. 311 $a0-471-41090-X 320 $aIncludes bibliographical references and index. 327 $aFUNCTIONAL METABOLISM: REGULATION AND ADAPTATION; CONTENTS; Preface; Contributors; Chapter 1 Principles of Metabolic Control; Key Concepts; Metabolic Renaissance In Post Genome Era?; Metabolic Engineering; Metabolic Regulation versus Metabolic Control; Complexity of Metabolism and Concept of Biochemical Unity; Basis of Metabolic Control; Pacemaker Enzymes; Identification of a Pacemaker Enzyme; Enzyme Purification; Cautionary Note about Relating In Vitro Kinetic Studies of a Purified Enzyme to Its In Vivo Function and Control; Compartmentation of Metabolism 327 $aFormulation of a Theory of Metabolic ControlMetabolic Control Analysis; Mechanisms of Metabolic Control; Coarse Metabolic Control; Fine Metabolic Control; Concluding Remarks; Chapter 2 Enzymes: The Basis of Catalysis; Introduction; Enzyme Structure; Thermodynamics and Kinetic Theory of Enzyme Function; Thermodynamic Aspects of Kinetic Function: Processes Not Under Enzyme Control; Cellular Equilibria and Enzymes; Reaction Rate Theories; How Enzymes Influence Reaction Rates; How Enzyme-Catalyzed Reactions Occur: Lysozyme as a Model of Transition State Theory 327 $aWhen Enzymes Need Extra Help: Coenzymes and Their FunctionsCoenzymes That Transfer High Energy Phosphate; Coenzymes That Accept and Donate Electrons; Coenzymes That Activate Substrates; Kinetic Mechanisms of Enzyme Action; Development of Rate Equations: Simple Solution Kinetics; The Haldane Relationship; Multisubstrate Reactions; Cooperative Enzyme Mechanism; Allosteric Enzyme Activation and Inhibition; Enzyme Inhibition; Temperature Effects on Enzyme Function; Estimating Kinetic Parameters from Enzyme Velocity Data (the Influence of Error Structure) 327 $aChapter 3 Enzymes in the Cell: What's Really Going On?Introduction; Basic Enzyme Mechanism Under In Vivo Conditions; Effect of Enzyme-Substrate Binding; Effect of Reaction Reversibility; Effect of Substrate and Product Binding Combined with Reaction Reversibility; Time Course of the Complete Enzyme Mechanism; Simple Enzyme Systems; Simple Enzyme Pathways under In Vivo Conditions; Thought Experiment: Regulating Flux In Vivo; Mathematical Modeling of the Linear System; Branch Points and Irreversible Enzymes in Pathways; Simple Enzyme Pathways and Crossover Plots 327 $aBasics of Metabolic Control AnalysisMCA Analysis and Metabolic Pathways; Controlling Pathway Flux under In Vivo Conditions: Direct Calculation of Control Coefficients; Controlling Pathway Flux under In Vivo Conditions: Indirect Calculations of Control Coefficients; Relating Flux Control Coefficients to Pathway Regulation; Potential of an Enzyme to Be Regulated; Metabolic Simulation; Supply versus Demand; Feedback Inhibition; Formation of Multienzyme Complexes; Chapter 4 Signal Transduction Pathways and the Control of Cellular Responses to External Stimuli 327 $aFunction and Structure of Signaling Pathways 330 $aFunctional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism, and covers the interrelationship of metabolism to life processes of the whole organism. The book lays out a structured approach to the metabolic basis of disease, including discussion of the normal pathways of metabolism, altered pathways leading to disease, and use of molecular genetics in diagnosi 606 $aMetabolism$xRegulation 606 $aHomeostasis 606 $aAdaptation (Physiology) 606 $aCellular signal transduction 615 0$aMetabolism$xRegulation. 615 0$aHomeostasis. 615 0$aAdaptation (Physiology) 615 0$aCellular signal transduction. 676 $a572.4 676 $a572/.4 701 $aStorey$b K. B$g(Kenneth B.)$0854229 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910146072403321 996 $aFunctional metabolism$92252052 997 $aUNINA LEADER 05323nam 2200769 a 450 001 9910791726703321 005 20161219111758.0 010 $a1-4833-2830-9 010 $a1-4522-5092-8 035 $a(CKB)2560000000089882 035 $a(EBL)997109 035 $a(OCoLC)809773985 035 $a(SSID)ssj0000704398 035 $a(PQKBManifestationID)12267951 035 $a(PQKBTitleCode)TC0000704398 035 $a(PQKBWorkID)10719006 035 $a(PQKB)11759658 035 $a(MiAaPQ)EBC997109 035 $a(OCoLC)1007858857 035 $a(StDuBDS)EDZ0000159144 035 $a(EXLCZ)992560000000089882 100 $a20130912d1998 fy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAging, social inequality, and public policy$b[electronic resource] /$fFred C. Pampel 210 $aThousand Oaks $cPine Forge$dc1998 215 $a1 online resource (xiv, 176 p.) $cill 225 1 $aSociology for a new century 225 0$aSociology for a new century 300 $aDescription based upon print version of record. 311 $a1-322-41851-9 311 $a0-8039-9095-2 320 $aIncludes bibliographical references (p. 153-166) and index. 327 $aCover; Contents; Foreword; Preface; Acknowledgments; Chapter 1 - Images of Old Age; Improvements in the Status of the Elderly; Remaining Problems for the Elderly; Changing Stereotypes; Inequality in Old Age; Problems of Public Funding; Problems of Health Care; A Combined View of Old Age; Conclusion; Chapter 2 - Public Policy in Old Age; Government Social Protection; The Logic of Social Protection; A Brief History; A Welfare State for the Elderly; The Meaning of Social Security; Support for the Elderly in the United States; Support for Other Age Groups; Support for Public Programs 327 $aSocial Insurance and Means TestingA European Perspective; Sources of Inequality; The Politics of Inequality; Conclusion; Chapter 3 - Class Differences before and during Old Age; Stability and Change in Inequality from Middle Age to Old Age; Sources of Declining Inequality in Old Age; Sources of Increasing Inequality in Old Age; Studying Changes over the Life Course; Changes in Work and Retirement; Changes in Health, Disability, and Mortality; Changes in Poverty and Income; Conclusion; Chapter 4 - Race, Ethnic, and Gender Differences in Old Age; Combining Negative Statuses 327 $aLeveling of Race and Ethnic DifferencesDouble Jeopardy in Old Age; Leveling and Double Jeopardy in Race and Ethnic Differences; Retirement; Health; Poverty and Income; Gender and Age; Familism; Economic Sources of Familism; Cultural Sources of Familism; Conclusion; Chapter 5 - Old Age Support in Comparative Perspective; Comparing Public Pension Systems; National Levels of Spending; Public Pension Rights; Public Pension Programs and Inequality; Pension Regimes; Aging and Pension Support in Japan; Sources of National Divergence; Class Interests; Classes in the United States 327 $aRole of the Middle ClassState Structure; A Feminist Critique; Conclusion; Chapter 6 - Inequality across Age Groups and Generations; Consequences of Population Aging; The Nature and Sources of Generational Inequity; A Reversal of Generational Support; The Need for Policy Changes; Opposition to Claims of Generational Inequity; Exaggerations of Generational Inequity; Real Sources of Concern; The Historical Context of Debates over Generational Inequity; The National Context of Debatesover Generational Inequity; Spending for Children and the Elderly 327 $aSources of Relative Spending on Children and the ElderlyConclusion; Epilogue; References; Index 330 $a Fred C. Pampel describes how age combines with other components of inequality by comparing the influence of group membership on social inequality before and after the life course transition to old age. He looks at the differences in public policy and how age inequality -- more than the other sources of inequality -- relates closely to government policies and studies other societies in which both age group differences and overall inequality differ from those in the United States. Pampel makes a comparison of the United States with other nations a central component of the book, providing grea 410 0$aSociology for a New Century Series 606 $aOlder people$xSocial conditions 606 $aOlder people$zUnited States$xSocial conditions 606 $aOlder people$xGovernment policy 606 $aOlder people$xGovernment policy$zUnited States 606 $aOld age assistance 606 $aOld age assistance$zUnited States 606 $aEquality 606 $aEquality$zUnited States 615 0$aOlder people$xSocial conditions. 615 0$aOlder people$xSocial conditions. 615 0$aOlder people$xGovernment policy. 615 0$aOlder people$xGovernment policy 615 0$aOld age assistance. 615 0$aOld age assistance 615 0$aEquality. 615 0$aEquality 676 $a305.26 700 $aPampel$b Fred C$0140542 801 0$bStDuBDS 801 1$bStDuBDS 906 $aBOOK 912 $a9910791726703321 996 $aAging, social inequality, and public policy$93768109 997 $aUNINA