LEADER 04694nam 2200769 450 001 9910790520603321 005 20231031225512.0 010 $a0-691-12240-7 010 $a1-4008-4938-1 024 7 $a10.1515/9781400849383 035 $a(CKB)2550000001130561 035 $a(EBL)1422524 035 $a(SSID)ssj0001174412 035 $a(PQKBManifestationID)11620706 035 $a(PQKBTitleCode)TC0001174412 035 $a(PQKBWorkID)11107081 035 $a(PQKB)10127919 035 $a(OCoLC)868970258 035 $a(MdBmJHUP)muse37088 035 $a(DE-B1597)447209 035 $a(OCoLC)861199758 035 $a(OCoLC)979835777 035 $a(DE-B1597)9781400849383 035 $a(Au-PeEL)EBL1422524 035 $a(CaPaEBR)ebr10782425 035 $a(CaONFJC)MIL530372 035 $a(OCoLC)860923072 035 $a(MiAaPQ)EBC1422524 035 $a(EXLCZ)992550000001130561 100 $a20040805h20052005 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aRobustness and evolvability in living systems /$fAndreas Wagner 205 $aCourse Book 210 1$aPrinceton, New Jersey :$cPrinceton University Press,$d[2005] 210 4$dİ2005 215 $a1 online resource (384 p.) 225 0 $aPrinceton Studies in Complexity ;$v24 225 0$aPrinceton studies in complexity 300 $aDescription based upon print version of record. 311 $a0-691-13404-9 311 $a1-299-99121-1 320 $aIncludes bibliographical references (pages [323]-358) and index. 327 $aIntroduction -- The genetic alphabet -- The genetic code -- RNA structure -- Proteins and point mutations -- Proteins and recombination -- Regulatory DNA regions and their reorganization in evolution -- Metabolic pathways -- Metabolic networks -- Drosophila segmentation and other gene regulatory networks -- Phenotypic traits, cryptic variation, and human diseases -- The many ways of building the same body -- Neutral spaces -- Evolvability and neutral mutations -- Redundancy of parts or distributed robustness? -- Robustness as an evolved adaptation to mutations -- Robustness as an evolved adaptation to environmental change and noise -- Robustness and fragility: advantages to variation and trade-offs -- Robustness in natural systems and self-organization -- Robustness in man-made systems. 330 $aAll living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems tackles this perplexing paradox. The book explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms' robustness. Andreas Wagner looks at this problem from the ground up, starting with the alphabet of DNA, the genetic code, RNA, and protein molecules, moving on to genetic networks and embryonic development, and working his way up to whole organisms. He then develops an evolutionary explanation for robustness. Wagner shows how evolution by natural selection preferentially finds and favors robust solutions to the problems organisms face in surviving and reproducing. Such robustness, he argues, also enhances the potential for future evolutionary innovation. Wagner also argues that robustness has less to do with organisms having plenty of spare parts (the redundancy theory that has been popular) and more to do with the reality that mutations can change organisms in ways that do not substantively affect their fitness. Unparalleled in its field, this book offers the most detailed analysis available of all facets of robustness within organisms. It will appeal not only to biologists but also to engineers interested in the design of robust systems and to social scientists concerned with robustness in human communities and populations. 410 0$aPrinceton Studies in Complexity 606 $aMolecular evolution 606 $aMutation (Biology) 606 $aBiological systems$xStability 606 $aRobust control 615 0$aMolecular evolution. 615 0$aMutation (Biology) 615 0$aBiological systems$xStability. 615 0$aRobust control. 676 $a572.8/38 686 $aWH 2600$2rvk 700 $aWagner$b Andreas$f1967 January 26-$01514248 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910790520603321 996 $aRobustness and evolvability in living systems$93749216 997 $aUNINA