LEADER 04605nam 2200625Ia 450 001 9910465429503321 005 20200520144314.0 010 $a1-61761-864-0 035 $a(CKB)2560000000067957 035 $a(EBL)3017851 035 $a(SSID)ssj0000411458 035 $a(PQKBManifestationID)12144844 035 $a(PQKBTitleCode)TC0000411458 035 $a(PQKBWorkID)10355071 035 $a(PQKB)10095879 035 $a(MiAaPQ)EBC3017851 035 $a(Au-PeEL)EBL3017851 035 $a(CaPaEBR)ebr10654822 035 $a(OCoLC)923653915 035 $a(EXLCZ)992560000000067957 100 $a20091215d2010 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAggressive breast cancer$b[electronic resource] /$fRegina H. DeFrina, editor 210 $aNew York $cNova Science Publishers$dc2010 215 $a1 online resource (276 p.) 225 1 $aCancer etiology, diagnosis and treatments series 300 $aDescription based upon print version of record. 311 $a1-60876-881-3 320 $aIncludes bibliographical references and index. 327 $a""AGGRESSIVE BREAST CANCER ""; ""AGGRESSIVE BREAST CANCER ""; ""CONTENTS ""; ""PREFACE""; ""RESEARCH AND REVIEW ARTICLES""; ""THE HER2 ONCOGENE IN BREAST CANCER ""; ""ABSTRACT ""; ""INTRODUCTION ""; ""HER PROTEIN RECEPTORS: SIGNAL TRANSDUCTION AND ONCOGENESIS ""; ""Intracellular Signaling Pathways ""; ""HER-Induced Cell Cycle Progression and Survival Pathways ""; ""OVER EXPRESSION OF HER2 AND THE PROGNOSIS OF INVASIVE BREAST CANCER ""; ""HER2 as A Prognostic Factor: Node-Positive Versus Node-Negative Disease""; ""HER Status and Lymphoid Infiltration "" 327 $a""HER2 and Progression of Early Breast Cancer Lesions to Invasive Carcinomas""""Relationship Between HER2 and Estrogen Receptor Expression ""; ""HER2 ABNORMALITIES IN OTHER TYPES OF BREAST MALIGNANCIES ""; ""HER2 ABNORMALITIES IN OTHER TYPES OF BREAST MALIGNANCIES ""; ""Evaluating HER2 in Breast Tissue ""; ""HER2 TARGETED THERAPY IN BREAST CANCER ""; ""The Role of Trastuzumab in HER2 Overexpressing Breast Cancer ""; ""The Role of Pertuzumab in HER2 Overexpressing Breast Cancer ""; ""The Role of Trastuzumab-DM1 in HER2 Overexpressing Breast Cancer "" 327 $a""Inhibiting Several HER Receptors: The Role of Lapatinib in HER2 Overexpressing Breast Cancer """"Circulating Serum HER2 Levels ""; ""PROPOSED RESISTANCE TO ANTI-HER2 THERAPIES ""; ""Altered Receptor-Antibody Interaction ""; ""Increased Signaling from other Receptors of the HER Family ""; ""Increased Signaling from other Receptors Activating the MAPK and PI3K Pathways ""; ""Constitutive Activation of Downstream Effectors ""; ""HER2 OVEREXPRESSION AND CHEMOTHERAPY ""; ""Anthracyclines ""; ""Taxanes ""; ""HER2 OVEREXPRESSION AND HORMONAL THERAPY "" 327 $a""CNS DISEASE IN HER2 OVEREXPRESSED BREAST CANCER """"CNS Metastases in Adjuvant Trials of Trastuzumab ""; ""Prognosis of CNS Metastases in HER2 Overexpressing Breast Cancer""; ""CONCLUSION ""; ""REFERENCES""; ""MULTI-DRUG RESISTANCE AS A PROBLEM CHALLENGING BREAST CANCER CHEMOTHERAPY ""; ""ABSTRACT ""; ""INTRODUCTION""; ""1) Non-Cellular MDR Mechanisms ""; ""2) Cellular MDR Mechanisms: ""; ""1. Changes in the intracellular accumulation and distribution of the drug ""; ""1a. Alteration of drug influx ""; ""1b. Alteration of drug efflux ""; ""NORMAL TISSUE DISTRIBUTION"" 327 $a""PHYSIOLOGICAL FUNCTIONS OF P-GP """"PHARMACOLOGICAL FUNCTIONS OF P-GP ""; ""P-GP SUBSTRATES ""; ""2. Increase in Drug Detoxification ""; ""3. Alterations of Drug Targets ""; ""4. Increase in DNA Repair Mechanism ""; ""5. Changes in Key Genes Controlling Cell Proliferation ""; ""5a. Changes in genes responsible for cell cycle control ""; ""5b. Abrogation of apoptosis ""; ""6. Micro-Environmental Stress-Mediated Resistance of Solid Tumors ""; ""7. Cancer Cell Dormancy and Resistant Cancer Stem Cells ""; ""MODULATION OF MDR PHENOTYPE "" 327 $a""I. Circumvention of Drug Resistance Induced by P-Gp Pump Protein "" 410 0$aCancer etiology, diagnosis, and treatments. 606 $aBreast$xCancer 606 $aBreast$xDiseases 608 $aElectronic books. 615 0$aBreast$xCancer. 615 0$aBreast$xDiseases. 676 $a616.99/449 676 $a616.99/449 701 $aDeFrina$b Regina H$0898149 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910465429503321 996 $aAggressive breast cancer$92006768 997 $aUNINA LEADER 03989nam 2200685Ia 450 001 9910789624203321 005 20230207214044.0 010 $a0-8014-7512-0 010 $a0-8014-5848-X 024 7 $a10.7591/9780801458484 035 $a(CKB)2670000000078997 035 $a(OCoLC)726824287 035 $a(CaPaEBR)ebrary10457647 035 $a(SSID)ssj0000483144 035 $a(PQKBManifestationID)11300072 035 $a(PQKBTitleCode)TC0000483144 035 $a(PQKBWorkID)10528757 035 $a(PQKB)11418637 035 $a(MiAaPQ)EBC3138025 035 $a(DE-B1597)481750 035 $a(OCoLC)984649128 035 $a(DE-B1597)9780801458484 035 $a(Au-PeEL)EBL3138025 035 $a(CaPaEBR)ebr10457647 035 $a(CaONFJC)MIL760186 035 $a(EXLCZ)992670000000078997 100 $a20090313d2009 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBush wives and girl soldiers$b[electronic resource] $ewomen's lives through war and peace in Sierra Leone /$fChris Coulter 210 $aIthaca $cCornell University Press$d2009 215 $a1 online resource (303 p.) 225 1 $aCornell paperbacks 300 $aBibliographic Level Mode of Issuance: Monograph 311 0 $a1-336-28900-7 311 0 $a0-8014-4782-8 320 $aIncludes bibliographical references and index. 327 $tFront matter --$tContents --$tAcknowledgments --$tIntroduction --$t1. A Decade of War- Centuries of Uncertainty --$t2. Gendered Lives in Rural Sierra Leone --$t3. Abduction and Everyday Rebel Life --$t4. From Rape Victims to Female Fighters --$t5. Reconciliation or Revenge --$t6. Surviving the Postwar Economy --$t7. Coming Home - Domesticating the Bush --$tConclusion --$tNotes --$tReferences --$tIndex 330 $aDuring the war in Sierra Leone (1991-2002), members of various rebel movements kidnapped thousands of girls and women, some of whom came to take an active part in the armed conflict alongside the rebels. In a stunning look at the life of women in wartime, Chris Coulter draws on interviews with more than a hundred women to bring us inside the rebel camps in Sierra Leone. When these girls and women returned to their home villages after the cessation of hostilities, their families and peers viewed them with skepticism and fear, while humanitarian organizations saw them primarily as victims. Neither view was particularly helpful in helping them resume normal lives after the war. Offering lessons for policymakers, practitioners, and activists, Coulter shows how prevailing notions of gender, both in home communities and among NGO workers, led, for instance, to women who had taken part in armed conflict being bypassed in the demilitarization and demobilization processes carried out by the international community in the wake of the war. Many of these women found it extremely difficult to return to their families, and, without institutional support, some were forced to turn to prostitution to eke out a living. Coulter weaves several themes through the work, including the nature of gender roles in war, livelihood options in war and peace, and how war and postwar experiences affect social and kinship relations. 410 0$aCornell paperbacks. 606 $aWomen and war$zSierra Leone 606 $aWomen$xCrimes against$zSierra Leone 606 $aRural women$zSierra Leone$xSocial conditions 607 $aSierra Leone$xHistory$yCivil War, 1991-2002$xWomen 607 $aSierra Leone$xHistory$yCivil War, 1991-2002$xParticipation, Female 615 0$aWomen and war 615 0$aWomen$xCrimes against 615 0$aRural women$xSocial conditions. 676 $a966.404 700 $aCoulter$b Chris$f1969-$0703642 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910789624203321 996 $aBush wives and girl soldiers$91355814 997 $aUNINA