LEADER 03386nam 2200613 a 450 001 9910789405703321 005 20230725031500.0 010 $a1-283-14332-1 010 $a9786613143327 010 $a1-84816-367-3 035 $a(CKB)2670000000095736 035 $a(EBL)731333 035 $a(OCoLC)738434150 035 $a(SSID)ssj0000524181 035 $a(PQKBManifestationID)12213183 035 $a(PQKBTitleCode)TC0000524181 035 $a(PQKBWorkID)10546100 035 $a(PQKB)11062794 035 $a(MiAaPQ)EBC731333 035 $a(WSP)0000P630 035 $a(Au-PeEL)EBL731333 035 $a(CaPaEBR)ebr10479770 035 $a(CaONFJC)MIL314332 035 $a(EXLCZ)992670000000095736 100 $a20110714d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMicroRNAs in development and cancer$b[electronic resource] /$feditor, Frank J. Slack 210 $aLondon $cImperial College Press$d2011 215 $a1 online resource (300 p.) 225 1 $aMolecular medicine and medicinal chemistry ;$vv. 1 300 $aDescription based upon print version of record. 311 $a1-84816-366-5 320 $aIncludes bibliographical references and index. 327 $aContents; Preface; 1 Introduction to Gene Regulation by Small RNAs Allison L. Abbott; 2 The Emerging Non-Coding RNA World Ahmad M. Khalil, Maite Huarte and John L. Rinn; 3 MicroRNAs in C. elegans Development Helge Großhans and Almuth E. Mu?llner; 4 MicroRNAs in Mammalian Development Andrea Ventura; 5 MicroRNAs in Hematopoietic Development Silvia Monticelli; 6 MicroRNAs Function as Tumor Suppressor Genes and Oncogenes Aurora Esquela-Kerscher; 7 Simultaneous Detection of Primary, Precursor and Mature MicroRNAs by qPCR Jinmai Jiang, Eun Joo Lee and Thomas D. Schmittgen 327 $a8 Single Nucleotide Polymorphisms in MicroRNAs and MicroRNA Binding Sites with Roles in Cancer Lena J. Chin and Frank J. Slack9 MicroRNAs as Potential Diagnostics and Therapeutics Trupti Paranjape, Jae Choi and Joanne B.Weidhaas; 10 MicroRNA Target Prediction Isidore Rigoutsos and Aristotelis Tsirigos; 11 Non-Coding RNAs in Cancer - The Other Part of the Story Muller Fabbri and George A. Calin; Index 330 $aMicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represen 410 0$aMolecular medicine and medicinal chemistry ;$vv. 1. 606 $aCancer$xGenetic aspects 606 $aSmall interfering RNA 615 0$aCancer$xGenetic aspects. 615 0$aSmall interfering RNA. 676 $a572.88 701 $aSlack$b Frank J$01487345 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910789405703321 996 $aMicroRNAs in development and cancer$93707141 997 $aUNINA LEADER 03206nam 2200613 450 001 9910815902403321 005 20230421054922.0 010 $a3-11-086282-4 024 7 $a10.1515/9783110862829 035 $a(CKB)3360000000516276 035 $a(EBL)4009040 035 $a(SSID)ssj0001553393 035 $a(PQKBManifestationID)16170642 035 $a(PQKBTitleCode)TC0001553393 035 $a(PQKBWorkID)14812695 035 $a(PQKB)10585492 035 $a(MiAaPQ)EBC4009040 035 $a(DE-B1597)54646 035 $a(OCoLC)979883317 035 $a(DE-B1597)9783110862829 035 $a(Au-PeEL)EBL4009040 035 $a(CaPaEBR)ebr11072048 035 $a(CaONFJC)MIL808100 035 $a(OCoLC)959844032 035 $a(EXLCZ)993360000000516276 100 $a20160223h19921992 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aProbability theory $eproceedings of the 1989 Singapore probability Conference held at the National University of Singapore, June 8-16, 1989 /$feditors, Louis H. Y. Chen [and three others] 205 $aReprint 2015 210 1$aBerlin, [Germany] ;$aNew York, [New York] :$cWalter de Gruyter,$d1992. 210 4$d©1992 215 $a1 online resource (224 p.) 225 0 $aDe Gruyter Proceedings in Mathematics 300 $aDescription based upon print version of record. 311 $a3-11-012233-2 320 $aIncludes bibliographical references. 327 $tFrontmatter -- $tPreface -- $tAdvisors -- $tTable of Contents -- $tWorkshop lectures -- $tInverse questions in stochastic differential geometry / $rPinsky, Mark A. -- $tEstimates on the heat kernel for second order divergence form operators / $rStroock, Daniel W. -- $tSpecial invited lecture -- $tOn Malliavin calculus / $rItô, Kiyosi -- $tInvited lectures -- $tThoughts on the modelling and identification of random processes and fields subject to possible long-range dependence / $rHeyde, C. C. / Gay, Roger -- $tWhite noise and Gaussian random fields / $rHida, Takeyuki -- $tConnectivity of certain graphs on halfspaces, quarter spaces, ...· / $rKesten, Harry -- $tOne dimensional Schrödinger operators with stationary deterministic potentials / $rKotani, Shinichi -- $tLyapunov exponents and rotation numbers of linear systems with real noise* / $rPinsky, Mark A. / Wihstutz, Volker -- $tSome results about test and generalized functionals of white noise· / $rPotthoff, Jürgen / Yan, Jia-an -- $tTail approximations for maxima of random fields / $rSiegmund, David O. -- $tA way of using auxiliary randomization / $rStein, Charles -- $tDisintegration problems in Wiener functional integrations / $rWatanabe, Shinzo -- $tAppendices -- $tList of contributors -- $tList of participants -- $tBackmatter 410 3$aDe Gruyter Proceedings in Mathematics 606 $aProbabilities$vCongresses 615 0$aProbabilities 676 $a519.2 686 $aQH 170$2rvk 702 $aChen$b Louis H. Y. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910815902403321 996 $aProbability Theory$9438114 997 $aUNINA