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100   $a20121212d2011      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aNeurodegeneration$b[electronic resource] $emetallostasis and proteostasis /$fedited by Danilo Milardi and Enrico Rizzarelli
210   $aCambridge $cRSC Pub.$d2011
215   $a1 online resource (285 p.)
225 1 $aRSC drug discovery series,$x2041-3203 ;$vno. 7
300   $aDescription based upon print version of record.
311   $a1-84973-050-4 
320   $aIncludes bibliographical references and index.
327   $ai-iv; v-viii; xi-xiv; 1-17.PDF.pdf; 18-45; 46-68; 69-82; 83-111; 112-140; 141-151; 152-173; 174-211; 212-225; 226-248; 249-258; 259-270
330   $aSince Alois Alzheimer described the results of his postmortem studies in 1906, significant strides have been made in understanding the pathogenesis of neurodegenerative diseases. Substantial evidence has accumulated indicating that diverse neurodegenerative disorders might share a common pathological mechanism: the misfolding, aggregation and accumulation of proteins (termed ""amyloid"") in the brain. Metal ions have long been thought to catalyze protein misfolding initiating a cascade of events resulting in oxidative damage and neurodegeneration. They have, consequently, been seen as a suitab
410  0$aRSC drug discovery series ;$v7.
606   $aNervous system$xDegeneration
615  0$aNervous system$xDegeneration.
676   $a616.8047
701   $aMilardi$b Danilo$01487322
701   $aRizzarelli$b Enrico$01487323
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801  1$bMiAaPQ
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906   $aBOOK
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996   $aNeurodegeneration$93707115
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