LEADER 04622nam 2200589 450 001 9910789231303321 005 20230803034647.0 010 $a0-309-28570-4 010 $a0-309-28568-2 035 $a(CKB)3710000000103355 035 $a(EBL)3379217 035 $a(SSID)ssj0001219040 035 $a(PQKBManifestationID)11993474 035 $a(PQKBTitleCode)TC0001219040 035 $a(PQKBWorkID)11214196 035 $a(PQKB)10106635 035 $a(MiAaPQ)EBC3379217 035 $a(Au-PeEL)EBL3379217 035 $a(CaPaEBR)ebr10863871 035 $a(OCoLC)866949752 035 $a(EXLCZ)993710000000103355 100 $a20140503h20132013 uy| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNeurodegeneration $eexploring commonalities across diseases : workshop summary /$fMiriam Davis and Clare Stroud, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies 210 1$aWashington, District of Columbia :$cNational Academies Press,$d[2013] 210 4$dİ2013 215 $a1 online resource (107 p.) 300 $aDescription based upon print version of record. 311 $a0-309-28567-4 327 $a""Front Matter""; ""Reviewers""; ""Contents""; ""1 Introduction""; ""2 Rationale for Exploring Commonalities Across Neurodegenerative Diseases""; ""3 Protein Aggregation""; ""4 Transmissibility""; ""5 Mitochondrial Pathology""; ""6 Errors in RNA""; ""7 Closing Remarks""; ""Appendix A: References""; ""Appendix B: Statement of Task""; ""Appendix C: Workshop Agenda""; ""Appendix D: Registered Attendees"" 330 $a"Neurodegeneration: Exploring Commonalities Across Diseases is the summary of a workshop hosted by the Institute of Medicine's (IOM's) Forum on Neuroscience and Nervous System Disorders in Spring 2012 to explore commonalities across neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Participants from academia; pharmaceutical and biotechnology industries; government agencies such as the National Institutes of Health and the U.S. Department of Veterans Affairs (VA); patient advocacy groups; and private foundations presented and identified potential opportunities for collaboration across the respective research and development communities. This report identifies and discusses commonalities related to genetic and cellular mechanisms, identifies areas of fundamental science needed to facilitate therapeutics development, and explores areas of potential collaboration among the respective research communities. Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, ALS, and FTD, are becoming increasingly prevalent in the United States due to an aging population. Implications are grave for quality of life and health care costs. Research on neurodegenerative diseases has expanded greatly over the past four decades. Nevertheless, fundamental questions remain about the biology of these diseases, and further insights into the mechanisms of these diseases would help to inform the development of effective means to prevent and to efficiently treat them. Recent findings have revealed certain commonalities in genetic and cellular mechanisms across neurodegenerative diseases. These findings suggest that it might be valuable - at least in some cases - to change the traditional way of studying these diseases by no longer seeing each as an independent entity, but rather as clinical variants of common cellular and molecular biological defects. This approach could help enhance basic scientific understanding of neurodegenerative disease, and could help with the development of biomarkers and new therapeutics." 606 $aNervous system$xDegeneration$vCongresses 606 $aBiology$xResearch$vCongresses 615 0$aNervous system$xDegeneration 615 0$aBiology$xResearch 676 $a616.804 702 $aDavis$b Miriam 702 $aStroud$b Clare 712 02$aInstitute of Medicine (U.S.).$bForum on Neuroscience and Nervous System Disorders, 712 02$aInstitute of Medicine (U.S.).$bBoard on Health Sciences Policy, 712 12$aNeurodegeneration: Opportunities for Collaboration Across Disease-Specific Research and Development Communities (Workshop) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910789231303321 996 $aNeurodegeneration$91897685 997 $aUNINA