LEADER 04580nam 2200589 450 001 9910788294603321 005 20230120013023.0 035 $a(CKB)2670000000609041 035 $a(EBL)2012263 035 $a(SSID)ssj0001540773 035 $a(PQKBManifestationID)11824805 035 $a(PQKBTitleCode)TC0001540773 035 $a(PQKBWorkID)11534202 035 $a(PQKB)10788580 035 $a(MiAaPQ)EBC2012263 035 $a(Au-PeEL)EBL2012263 035 $a(CaPaEBR)ebr11042972 035 $a(CaONFJC)MIL768352 035 $a(OCoLC)912312563 035 $a(EXLCZ)992670000000609041 100 $a20150424h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aStellate cells in health and disease /$fedited by Chandrashekhar R. Gandhi, Massimo Pinzani 210 1$aAmsterdam, [Netherlands] :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (335 p.) 300 $aDescription based upon print version of record. 311 $a0-12-800544-0 311 $a0-12-800134-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Stellate Cells in Health and Disease; Copyright Page; Dedication; Contents; List of Contributors; Foreword; What have we learned?; The outlook for anti-fibrotic treatment; References; Preface; 1 History and Early Work; 1.1 Discovery of Hepatic Stellate Cells; 1.2 HSCs and Vitamin A Homeostasis; 1.3 Morphological Characteristics of HSCs; 1.4 HSCs and Liver Fibrosis; 1.5 Isolation and Culture of HSCs; 1.6 Activation and Transdifferentiation of HSCs; 1.7 Markers for HSCs; 1.8 Perspective; References; 2 Hepatic Stellate Cell Culture Models; 2.1 Isolation of Hepatic Stellate Cells 327 $a2.2 Single Cell Culture2.3 In Vitro- Versus In Vivo-Activated HSCs; 2.4 Single Cell Culture and 2D: Importance of Adhesion, Arg-Gly-Asp, and Matrix Components; 2.5 HSC Co-Cultures with Kupffer Cells, Hepatocytes, LSEC, HCC, and CC Cells; 2.6 In Vitro 3D Culture Systems; 2.7 Conclusions; References; 3 Hepatic Fibrosis: A Global Clinical Problem; 3.1 Introduction; 3.2 Chronic Viral Hepatitis; 3.2.1 Alcohol-induced liver fibrosis; 3.3 NAFLD and NASH; 3.4 Autoimmune Hepatitis, Primary Biliary Cirrhosis, and Primary Sclerosing Cholangitis; 3.5 Etiology-Driven Liver Fibrosis; 3.5.1 Perspectives 327 $aReferences4 Stellate Cells and Hepatic Fibrosis; 4.1 Introduction; 4.2 Pathogenesis of Hepatic Fibrosis; 4.2.1 Pathological and clinical associations of hepatic fibrosis; 4.2.2 ECM composition and matrix homeostasis; 4.2.3 Cellular sources of ECM; 4.3 HSCs and Hepatic Fibrosis; 4.3.1 Initiation; 4.3.2 Perpetuation; 4.3.2.1 Retinoid loss; 4.3.2.2 Fibrogenesis; 4.3.2.3 Matrix turnover; 4.3.2.4 Chemotaxis; 4.3.2.5 Proliferation; 4.3.2.6 Contractility; 4.3.2.7 Immunoregulation; 4.3.3 Regression; 4.3.3.1 Apoptosis; 4.3.3.2 Senescence; 4.3.3.3 Reversion to an inactivated phenotype 327 $a4.4 New and Emerging Pathways of HSC Activation4.5 Conclusions; References; 5 Cytokine Production and Signaling in Stellate Cells; 5.1 Introduction; 5.2 Platelet-Derived Growth Factor; 5.3 Angiogenic Cytokines; 5.4 TGF-? Superfamily; 5.5 Chemokines; 5.6 Tumor Necrosis Factor Superfamily; 5.7 Interleukins and Interferons; 5.8 Adipokines and Other Cytokines Related to Metabolism; 5.9 Osteopontin; 5.10 Perspective; References; 6 Stellate Cells, Portal Myofibroblasts, and Epithelial-to-Mesenchymal Transition; 6.1 Introduction; 6.2 Hepatic Stellate Cells 327 $a6.2.1 Contribution of HSCs to liver fibrosis6.2.1.1 HSCs/Myofibroblasts are the primary target of anti-fibrotic therapy; 6.2.1.2 Reversibility of liver fibrosis; 6.2.1.3 Inactivation of HSCs (iHSCs); 6.2.2 Other functions of HSCs; 6.2.2.1 Distinct functions of senescent HSCs; 6.2.2.2 HSC as regulatory bystanders; 6.2.2.3 HSCs as regulators of hepatocellular damage; 6.2.2.4 The role of HSCs in liver regeneration; 6.3 Portal Fibroblasts; 6.3.1 Characterization of PFs; 6.4 Epithelial-to-Mesenchymal Transition; 6.5 Perspective; References; 7 Matrix Metalloproteinases and Their Inhibitors 327 $a7.1 Introduction 606 $aKupffer cells 615 0$aKupffer cells. 676 $a612.35 702 $aGandhi$b Chandrashekhar 702 $aPinzani$b Massimo 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910788294603321 996 $aStellate cells in health and disease$93855525 997 $aUNINA