LEADER 05564nam 2200649 450 001 9910788087603321 005 20200520144314.0 010 $a0-85709-722-9 035 $a(CKB)2670000000578038 035 $a(EBL)1934461 035 $a(SSID)ssj0001432235 035 $a(PQKBManifestationID)11852451 035 $a(PQKBTitleCode)TC0001432235 035 $a(PQKBWorkID)11389674 035 $a(PQKB)11681832 035 $a(Au-PeEL)EBL1934461 035 $a(CaPaEBR)ebr10990611 035 $a(CaONFJC)MIL664833 035 $a(OCoLC)897021743 035 $a(MiAaPQ)EBC1934461 035 $a(EXLCZ)992670000000578038 100 $a20141209h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiomaterials and medical device-associated infections /$fedited by L. Barnes and I. R. Cooper ; contributors, Y. Achermann [and thirty-one others] 210 1$aCambridge, England ;$aWaltham, Massachusetts ;$aKidlington, England :$cWoodhead Publishing,$d2015. 210 4$dİ2015 215 $a1 online resource (281 p.) 225 1 $aWoodhead Publishing Series in Biomaterials ;$vNumber 86 300 $aDescription based upon print version of record. 311 $a1-322-33551-6 311 $a0-85709-597-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Biomaterials and Medical Device-associated Infections; Copyright; Contents; List of contributors; Woodhead Publishing Series in Biomaterials; Part One Introduction to biomaterials and medical device-related infections; 1 Introduction to biomaterials and medical device-associated infections; 1.1 History of biomaterials; 1.2 Overview of current medical devices and applications; 1.3 Overview of problems associated with medical devices; 1.4 Introduction to the structure of this book; References; 2 Biofilms and implant-associated infections; 2.1 Introduction 327 $a2.2 Microbial profile of implant-associated infections2.3 Relevance of biofilms in implant-associated infections; 2.4 Structure and composition of biofilms; 2.5 Pathogenesis of biofilm infection; 2.6 Future trends; 2.7 Further information and advice; References; 3 In vivo infection studies; 3.1 Introduction; 3.2 Legitimacy of animal studies; 3.3 Choosing the right animal model to study device-associated infections; 3.4 Pros and cons of in vivo infection studies; 3.5 Correlation of outcome between animal and clinical studies; 3.6 Conclusion and future trends 327 $a3.7 Sources of further information and adviceAcknowledgments; References; 4 Diagnosis of biofilm-associated infections in medical devices; 4.1 Introduction; 4.2 Importance of detection of biofilm; 4.3 Sites of biofilm formation; 4.4 Collection of samples for biofilm detection; 4.5 Examples of methods for the detection of biofilms associated with infections; 4.6 Future trends; 4.7 Conclusion; Acknowledgement; References; 5 Diagnosis and treatment of implant-associated infections; 5.1 Introduction; 5.2 Risk factors and prevention; 5.3 Diagnosis; 5.4 Treatment; 5.5 Future trends; References 327 $aPart Two Technologies and materials for controlling biofilms6 Surface modification of biomaterials for biofilm control; 6.1 Introduction; 6.2 Principles of bacterial cell-biomaterial surface interactions; 6.3 Substrate specific biological response; 6.4 Looking at nature for inspiration; 6.5 Modifications to prevent initial stages of bacterial adhesion; 6.6 Methods to prevent irreversible attachment of microorganisms; 6.7 Mitigation of biofilm formation by attached organisms; 6.8 Future trends; References; 7 Surface nanoengineering for combating biomaterials infections; 7.1 Introduction 327 $a7.2 Modification of surface nano topography to inhibit bacterial adhesion7.3 Surface functionalization with eluting antibacterial agent; 7.4 Surface functionalization with anti-adhesive polymers; 7.5 Immobilization of bactericidal moieties on surfaces; 7.6 Conclusion and future trends; 7.7 Sources of further information and advice; References; 8 Bioactive biomaterials for controlling biofilms; 8.1 Introduction; 8.2 Definition of medical device; 8.3 Biomaterials; 8.4 Biomaterial applications in medical devices; 8.5 Post-implantation device-associated infections 327 $a8.6 Development of conventional antimicrobial biomaterials 330 $aDespite advances in materials and sterilisation, patients who receive biomaterials of medical device implants are still at risk of developing an infection around the implantation site. This book reviews the fundamentals of biomaterials and medical device related infections and methods and materials for the treatment and prevention of infection. The first part of the book provides readers with an introduction to the topic including analyses of biofilms, diagnosis and treatment of infection, pathology and topography. The second part of the book discusses a range of established and novel technolo 410 0$aWoodhead Publishing series in biomaterials ;$vNumber 86. 606 $aBiomedical materials$xBiocompatibility 615 0$aBiomedical materials$xBiocompatibility. 676 $a610.28 702 $aBarnes$b L. 702 $aCooper$b I. R. 702 $aAchermann$b Y. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910788087603321 996 $aBiomaterials and medical device-associated infections$93783205 997 $aUNINA