LEADER 02588oam 2200577I 450 001 9910787963403321 005 20170822114836.0 010 $a0-429-19468-4 010 $a1-4822-9786-8 024 7 $a10.1201/b17979 035 $a(CKB)2670000000560197 035 $a(EBL)1684509 035 $a(SSID)ssj0001416960 035 $a(PQKBManifestationID)11778137 035 $a(PQKBTitleCode)TC0001416960 035 $a(PQKBWorkID)11378060 035 $a(PQKB)10908163 035 $a(MiAaPQ)EBC1684509 035 $a(OCoLC)900343699 035 $a(CaSebORM)9781466561571 035 $a(EXLCZ)992670000000560197 100 $a20180331h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aComputational approaches to protein dynamics $efrom quantum to coarse-grained methods /$fedited by Monika Fuxreiter 205 $a1st edition 210 1$aBoca Raton ;$aLondon :$cCRC Press,$d[2015] 210 4$dİ2015 215 $a1 online resource (458 p.) 225 1 $aSeries in computational biophysics 300 $aDescription based upon print version of record. 311 $a1-4987-0353-4 311 $a1-322-62927-7 311 $a1-4665-6157-2 320 $aIncludes bibliographical references and index. 327 $asection 1. Introduction -- section 2. Enzymatic catalysis : multiscale QM/MM calculations -- section 3. Protein motions : flexibility analysis -- section 4. Approaches to intrinsically disordered proteins -- section 5. Large-scale dynamics -- section 6. Ensemble methods. 330 $a

This groundbreaking work addresses a crucial paradigm shift in structural molecular biology, illustrating how protein dynamics plays a central role in various functions, including enzymatic catalysis, protein-protein interactions, and the organization of complex assemblies. The book presents modern computational techniques for the characterization of proteins and their dynamic properties. The computational methods specifically address the dynamical aspects of protein functionalities, with special emphasis on the analysis of complex assemblies and intrinsically disordered proteins.

410 0$aSeries in computational biophysics. 606 $aProtein engineering 615 0$aProtein engineering. 676 $a572/.633 702 $aFuxreiter$b Monika$f1969- 801 0$bFlBoTFG 801 1$bFlBoTFG 906 $aBOOK 912 $a9910787963403321 996 $aComputational approaches to protein dynamics$93849450 997 $aUNINA