LEADER 06182nam 2200757 450 001 9910787755503321 005 20230803031953.0 010 $a3-11-029830-9 024 7 $a10.1515/9783110298307 035 $a(CKB)2670000000494623 035 $a(EBL)1113320 035 $a(OCoLC)862939080 035 $a(SSID)ssj0001041552 035 $a(PQKBManifestationID)11579680 035 $a(PQKBTitleCode)TC0001041552 035 $a(PQKBWorkID)11010177 035 $a(PQKB)11570768 035 $a(MiAaPQ)EBC1113320 035 $a(DE-B1597)178984 035 $a(OCoLC)1013939086 035 $a(OCoLC)1029820630 035 $a(OCoLC)1032683215 035 $a(OCoLC)1037982165 035 $a(OCoLC)1041976955 035 $a(OCoLC)1046613280 035 $a(OCoLC)1047011520 035 $a(OCoLC)1048336065 035 $a(OCoLC)979750441 035 $a(DE-B1597)9783110298307 035 $a(Au-PeEL)EBL1113320 035 $a(CaPaEBR)ebr10811257 035 $a(CaONFJC)MIL807933 035 $a(EXLCZ)992670000000494623 100 $a20130520h20132013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aStem cell-dependent therapies $emesenchymal stem cells in chronic inflammatory disorders /$fedited by Gerhard Gross, Thomas Ha?upl 210 1$aBerlin :$cWalter de Gruyter GmbH & Company,$d[2013] 210 4$d©2013 215 $a1 online resource (428 p.) 300 $aDescription based upon print version of record. 311 $a3-11-029826-0 327 $tFrontmatter -- $tPreface -- $tContributing authors -- $tTable of Contents -- $t1 Mesenchymal stem cells in the context of stem cell biology / $rDurand, Charles / Charbord, Pierre -- $t2 Are mesenchymal stem cells immune privileged? / $rZhang, Shang / Hollander, Anthony P. / Wraith, David C. -- $t3 Mesenchymal stem cell therapies for autoimmune diseases / $rTyndall, Alan / Bocelli-Tyndall, Chiara -- $t4 Mesenchymal stem cells in osteoarthritis and rheumatic disease / $rKurtz, Andreas / Oh, Su-Jun -- $t5 Mesenchymal stem cells in enthesis formation and repair / $rHoffmann, Andrea / Seiffart, Virginia / Laggies, Sandra / Gross, Gerhard -- $t6 Mesenchymal stem cells for clinical/therapeutic interventions of graft-versus-host disease / $rRingdén, Olle / Sadeghi, Behnam -- $t7 Mesenchymal stem cells for graft-versus-host disease in experimental animal models / $rSadeghi, Behnam / Ringdén, Olle -- $t8 Mesenchymal stem cells and organ transplantation : initial clinical results / $rPileggi, Antonello / Xu, Xiumin / Tan, Jianming / Ricordi, Camillo -- $t9 Stem cell therapy in patients with ischemic heart disease / $rQayyum, Abbas Ali / Kastrup, Jens -- $t10 Mesenchymal stem cells as a strategy for the treatment of multiple sclerosis and other diseases of the central nervous system / $rCordano, Christian / Kerlero de Rosbo, Nicole / Uccelli, Antonio -- $t11 Mesenchymal stem cells for the treatment of inflammatory bowel disease / $rDennis, James E. / Lord, James D. -- $t12 Mesenchymal stem cells in chronic lung diseases: COPD and lung fibrosis / $rWeiss, Daniel J. / Rojas, Mauricio -- $t13 Mesenchymal stem cells as therapeutics for liver repair and regeneration / $rPorada, Christopher D. / Almeida-Porada, Graça -- $t14 Mesenchymal stem cells attenuate renal fibrosis / $rAlmeida, Danilo Candido de / Taemi Origassa, Clarice Silvia / Bassi, Ênio Jose / Olsen Saraiva Câmara, Niels -- $t15 Immunomodulation by mesenchymal stem cells - a potential therapeutic strategy for type 1 diabetes / $rMounayar, Marwan / Magee, Ciara N. / Abdi, Reza -- $t16 Fibrogenic potential of human multipotent mesenchymal stem cells in inflammatory environments / $rGonelle-Gispert, Carmen / Bühler, Léo H. -- $t17 Mesenchymal stem cells and the tumor microenvironment / $rBergfeld, Scott A. / DeClerck, Yves A. -- $t18 Mesenchymal stem cells as a carrier for tumor-targeting therapeutics / $rChang, Astra I. / Nolta, Jan A. / Wu, Jian -- $t19 Systems biology approach to stem cells, tissues and inflammation / $rHäupl, Thomas -- $tIndex 330 $aMultipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD). This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation. 606 $aInflammation 606 $aMesenchymal stem cells$xTransplantation 610 $aAutoimmune Disorders. 610 $aImmunomodulation. 610 $aInflammation. 610 $aRegenerative Medicine. 610 $aStem Cells. 615 0$aInflammation. 615 0$aMesenchymal stem cells$xTransplantation. 676 $a616/.0473 701 $aGross$b Gerhard$f1949-$01527318 701 $aHa?upl$b Thomas$01527319 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910787755503321 996 $aStem cell-dependent therapies$93770000 997 $aUNINA