LEADER 05323nam 2200613 450 001 9910787490803321 005 20230120002237.0 010 $a0-12-801707-4 035 $a(CKB)3710000000329326 035 $a(EBL)1911719 035 $a(SSID)ssj0001433292 035 $a(PQKBManifestationID)11754761 035 $a(PQKBTitleCode)TC0001433292 035 $a(PQKBWorkID)11434604 035 $a(PQKB)11181932 035 $a(MiAaPQ)EBC1911719 035 $a(Au-PeEL)EBL1911719 035 $a(CaPaEBR)ebr11001159 035 $a(CaONFJC)MIL688127 035 $a(OCoLC)899211423 035 $a(EXLCZ)993710000000329326 100 $a20150113h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aEstrogen effects on traumatic brain injury $emechanisms of neuroprotection and repair /$fedited by Kelli Duncan ; contributors Marco Avila-Rodriguez [and twenty eight others] 210 1$aLondon, England :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (172 p.) 300 $aDescription based upon print version of record. 311 $a1-322-56845-6 311 $a0-12-801479-2 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Estrogen Effects on Traumatic Brain Injury; Copyright Page; Contents; About the Editor; List of Contributors; About the Contributors; Taura Barr; George E. Barreto; Suzanne R. Burstein; Francisco Capani; Laura L. Carruth; Nicolas Diotel; Miranda Reed; Colin J. Saldanha; James Simpkins; Farida Sohrabji; Introduction; Why Should I Care?; Rationale and Scope of the Book; 1 Historical Antecedents; Introduction; The "INS AND OUTS" of TBI: An Overview; A History of TBI from Antiquity Through the 19th Century; From the Bench to the Clinic: TBI in the 20th and 21st Century 327 $aConclusions and Future ThoughtsAcknowledgements; References; 2 Estrogen Actions in the Brain; Introduction; Steroid Hormones; Estrogens; Estrogen Receptors; Blood-Brain Barrier and Glial Cells; Estradiol and Brain Sexual Differentiation; Rapid Estrogen Signaling in the Brain; Estrogen-Sensitive Brain Regions; Sexually Dimorphic Brain Regions; Hippocampus; Cerebellum; Neurotransmitter Systems; Basal Forebrain Cholinergic System; Midbrain and Brainstem Serotonergic System; Catecholaminergic Neurons; Estrogens, Aging, and Neuroprotection; Additional Physiological Effects of Estrogens on the Body 327 $aConclusions and New DirectionsReferences; 3 Induction of Estrogen Response Following Injury; Introduction; Reactive Gliosis Following Injury; New Roles for Glial Cells as Steroid Synthesizing Cells; Induction of Glial Aromatase Following Injury; Neuroinflammation Induces Glial Aromatase Independent of Injury; Sex Differences in Cytokine Response Following Injury; Sex Differences in Glial Aromatase Expression Following Injury; Conclusion and Future Directions; Acknowledgements; References; 4 Astrocytic Aromatization and Injury; Aromatase is Expressed in Astroglia 327 $aWhat Induces Astrocytic Aromatase Expression?Glial Estrogen Synthesis and Neuroprotection; Apoptosis and Secondary Degeneration; Injury-Induced Cyto- and Neurogenesis; Summary and Future Directions; Further Reading; 5 Aromatase and Estrogens: Involvement in Constitutive and Regenerative Neurogenesis in Adult Zebrafish; Introduction; Unique Features Exhibited by the Brain of Teleost Fish; Neurosteroid Synthesis and Signaling in the Brain of Adult Zebrafish; Aromatase B Expression is Restricted to Radial Glia Acting Like Neural Stem Cells 327 $aInvolvement of Aromatase and Estrogens in Adult Neurogenesis and Brain Repair in ZebrafishComparison with Mammalian and Nonmammalian Models; Hypothesis and Perspectives for Estrogen Involvement in Neurogenesis Regarding New Advances in Zebrafish and New Literature...; Conclusion; References; 6 Neuroprotection by Exogenous Estrogenic Compounds Following Traumatic Brain Injury; Introduction; Neuroprotective Steroids; Estrogens, Progestagens and Androgens as Protective Compounds; Selective Estrogen Receptor Modulators; Selective Tissue Estrogenic Activity Regulator; TBI Protection Strategies 327 $aRole of Neuroactive Steroids in TBI 330 $a This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, methods, and their results, chapters explore what is known about the role of estrogens following damage to the brain. With topics covering induction of estrogen response, consequences of estrogen action, and mechanisms underlying estrogen mediated neuroprotection, Estrogen Effects on Traumatic Brain In 606 $aEstrogen$xTherapeutic use 615 0$aEstrogen$xTherapeutic use. 676 $a618.175061 702 $aDuncan$b Kelli 702 $aAvila-Rodriguez$b Marco 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910787490803321 996 $aEstrogen effects on traumatic brain injury$93700817 997 $aUNINA