LEADER 05590nam 2200697 450 001 9910787449803321 005 20230120002159.0 010 $a0-12-802913-7 010 $a0-12-802912-9 035 $a(CKB)3710000000340267 035 $a(EBL)1930000 035 $a(SSID)ssj0001548473 035 $a(PQKBManifestationID)16151469 035 $a(PQKBTitleCode)TC0001548473 035 $a(PQKBWorkID)14802043 035 $a(PQKB)10029647 035 $a(MiAaPQ)EBC1930000 035 $a(Au-PeEL)EBL1930000 035 $a(CaPaEBR)ebr11011299 035 $a(CaONFJC)MIL732185 035 $a(OCoLC)904208855 035 $a(EXLCZ)993710000000340267 100 $a20150204h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aProgress in molecular biology and translational science$hVolume 130$iMolecular basis of olfaction /$fedited by Richard Glatz 205 $aFirst edition. 210 1$aWaltham, Massachusetts :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (147 p.) 225 1 $aProgress in Molecular Biology and Translational Science,$x1877-1173 ;$vVolume 130 300 $aDescription based upon print version of record. 311 $a1-336-00903-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Molecular Basis of Olfaction; Copyright; Contents; Contributors; Preface; Chapter 1: Mammalian Olfactory Receptors: Molecular Mechanisms of Odorant Detection, 3D-Modeling, and Structure-Activity ...; 1. Mammalian Olfactory Receptors: From Genes to Proteins; 1.1. Genes and pseudogenes; 1.2. OR protein expression; 1.3. Olfactory signal transduction; 2. Olfactory Receptor Activity Regulation: Homodimerization, Binding Cooperativity, and Allostery; 3. Olfactory Receptor 3D Modeling and Use for Virtual Screening; 3.1. Model building; 3.2. Ligand virtual screening 327 $a3.3. GPCR inverse agonist, antagonist, and agonist ligands4. Odorant Ligands Structure-Activity Relationships; References; Chapter 2: Olfactory Signaling in Insects; 1. Introduction; 2. Insect Olfactory Receptors; 2.1. Structure; 2.2. Function; 2.3. Regulation; 3. Role of Orco; 4. Final Remarks; Acknowledgments; References; Chapter 3: Advances in the Identification and Characterization of Olfactory Receptors in Insects; 1. Introduction: The Molecular Bases of Odor Detection in Insects 327 $a2. Identification of Complete Insect OR Repertoires Could Only Be Achieved by Genome and Transcriptome Sequencing2.1. Advances in sequencing technologies and bioinformatic tools; 2.2. Exploitation of insect genomes for OR identification; 2.3. Developing insect antennal transcriptomes for OR identification; 3. Toward the Development of High Throughput Methods for the Functional Characterization of Insect ORs; 3.1. Description of the different methodologies; 3.1.1. In vitro heterologous expression systems; 3.1.2. In vivo heterologous expression systems; 3.2. Large OR repertoire deorphanization 327 $a3.3. Future perspective in the functional characterization of insect ORs3.3.1. Automatization for HT screens; 3.3.2. In silico HT screens; 4. Conclusion; References; Chapter 4: Olfactory Disruption: Toward Controlling Important Insect Vectors of Disease; 1. Introduction; 2. Detection of Olfactory Signals by Insect Vectors; 2.1. Odorant-binding and chemosensory proteins; 2.2. Odorant receptors; 2.3. Gustatory receptors; 2.4. Ionotropic receptors; 2.5. Sensory neuron membrane proteins; 2.6. Activation of olfactory receptor neurons; 2.7. Processing of olfactory signals in the brain 327 $a2.8. Volatile sensation in GRNs2.9. Interaction of repellents with olfactory receptors; 3. Discovery and Development of New Repellents; 4. Conclusion; References; Chapter 5: Pheromone Reception in Moths: From Molecules to Behaviors; 1. Introduction; 2. Structure of Antennae; 3. Antennal ORNs; 4. Molecular Components of Chemical Reception; 5. Pheromone Receptors; 6. Pheromone-Binding Proteins; 7. General Odorant-Binding Proteins; 8. Sensory Neuron Membrane Proteins; 9. Antennal Lobe; 10. Behavior; Acknowledgments; References; Index; Color Plate 330 $aThe scope of this volume of Progress in Molecular Biology and Translational Science includes the molecular regulation of olfactory processes in vertebrates and insects including detailed discussion of olfactory proteins, signaling cascades and olfactory receptor modeling. In addition, because insect olfaction is an important and emerging field, it is also discussed in the context of key research questions such as disruption of host-finding by insect disease vectors, elucidation of the diverse range of compounds that are detected by insects, and the detection of pheromones by moths. Comprehen 410 0$aProgress in molecular biology and translational science ;$vVolume 130. 606 $aOlfactory receptor genes 606 $aSmell$xMolecular aspects 606 $aInsects$xMolecular genetics 606 $aVertebrates$xMolecular genetics 615 0$aOlfactory receptor genes. 615 0$aSmell$xMolecular aspects. 615 0$aInsects$xMolecular genetics. 615 0$aVertebrates$xMolecular genetics. 676 $a591.1826 702 $aGlatz$b Richard 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910787449803321 996 $aProgress in molecular biology and translational science$93738778 997 $aUNINA