LEADER 05100nam 2200553 450 001 9910787343103321 005 20230807213625.0 010 $a1-910190-06-3 035 $a(CKB)3710000000356552 035 $a(EBL)1977392 035 $a(SSID)ssj0001467543 035 $a(PQKBManifestationID)11865280 035 $a(PQKBTitleCode)TC0001467543 035 $a(PQKBWorkID)11517040 035 $a(PQKB)10654529 035 $a(MiAaPQ)EBC1977392 035 $a(MiAaPQ)EBC5897779 035 $a(EXLCZ)993710000000356552 100 $a20191011d2015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCorynebacterium glutamicum $efrom systems biology to biotechnological applications /$fedited by Andreas Burkovski 210 1$aNorfolk, England :$cCaister Academic Press,$d[2015] 210 4$dİ2015 215 $a1 online resource (210 p.) 300 $aDescription based upon print version of record. 311 $a1-910190-05-5 320 $aIncludes bibliographical references and index. 327 $aContents; Contributors; Current Books of Interest; Preface; 1: Trends in Corynebacterium glutamicum Research and Application; From glutamate producer to a biotechnology workhorse; Systems biology; Corynebacterium glutamicum as a synthetic biology platform; Corynebacterium glutamicum-based green technology; 2: Proteomics of Corynebacterium glutamicum; Introduction; Understanding Corynebacterium glutamicum physiology with proteomics: application examples; Methods of Corynebacterium glutamicum proteomics; Conclusion and outlook 327 $a3: Developing Interpretation of Intracellular Metabolism of Corynebacterium glutamicum by Using Flux Analysis TechnologyIntroduction; Understanding the physiology of Corynebacterium glutamicum lysine production and glutamate production through conventional metabolic flux analysis; Fractional 13C enrichment-based metabolic flux analysis; Improvement in metabolic flux analysis precision; Conclusion; 4: Growth and Production Capabilities of Corynebacterium glutamicum: Interrogating a Genome-scale Metabolic Network Model; Introduction; The metabolic network of Corynebacterium glutamicum 327 $aStoichiometric modelling fundamentalsModel validation; Predicting production capabilities for amino acids; Uncertainties in metabolic network models; Metabolic flux analysis; Conclusions; 5: Metabolic Engineering of Corynebacterium glutamicum for Alternative Carbon Source Utilization; Introduction; Engineering of Corynebacterium glutamicum for alternative carbon sources; Complex carbon sources; Summary and outlook; 6: Manipulation of Nitrogen Metabolism and Alternative Nitrogen Sources for Corynebacterium glutamicum; Ammonium assimilation in Corynebacterium glutamicum 327 $aRegulation of nitrogen metabolismManipulation of nitrogen metabolism for amino acid production; Overexpression, deletion and heterologous expression of glutamate dehydrogenase; Overexpression of glutamine synthetases; Influence of glutamate synthase on L-glutamate biosynthesis; Changing ammonium assimilation and amino acid production by manipulation of ?-ketoglutarate supply; Influence of ammonium and glutamate transport systems on amino acid production; Manipulation of nitrogen regulation: influences on metabolite pools; Assimilation of alternative nitrogen sources; Concluding remarks 327 $a7: Transport, Degradation and Assimilation of Aromatic Compounds and their Regulation in Corynebacterium glutamicum Introduction; What do the Corynebacterium glutamicum genomes predict for degradation and assimilation of aromatic compounds?; Corynebacterium glutamicum grows on various aromatic compounds; Physiological adaptation of Corynebacterium glutamicum growing on aromatic compounds compared with carbohydrates; Uptake and transport of aromatic compounds in Corynebacterium glutamicum; Aromatic compounds degraded via protocatechuate branch of the ?-ketoadipate pathway 327 $aAromatic compounds degraded via the catechol branch of the ?-ketoadipate pathway 330 $aCorynebacterium glutamicum is most widely known for its role in the industrial production of L-glutamate and L-lysine and as a platform organism for the production of a variety of fine chemicals, biofuels and polymers. The organism's accessibility to genetic manipulation has resulted in a wealth of data on its metabolism and regulatory networks; this in turn makes C. glutamicum the model organism of choice in white biotechnology. A key development in recent years has been the engineering of C. glutamicum to utilize a broader spectrum of carbon sources (e.g. glycerol, galactose and pentose suga 606 $aCorynebacterium glutamicum$xMetabolism 615 0$aCorynebacterium glutamicum$xMetabolism. 676 $a579.373 702 $aBurkovski$b Andreas 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910787343103321 996 $aCorynebacterium glutamicum$91944960 997 $aUNINA