LEADER 05342nam 2200673 450 001 9910787265603321 005 20230120002054.0 010 $a0-12-802527-1 010 $a0-12-802215-9 035 $a(CKB)3710000000307997 035 $a(EBL)1882925 035 $a(SSID)ssj0001548651 035 $a(PQKBManifestationID)16153212 035 $a(PQKBTitleCode)TC0001548651 035 $a(PQKBWorkID)14802531 035 $a(PQKB)10778049 035 $a(MiAaPQ)EBC1882925 035 $a(Au-PeEL)EBL1882925 035 $a(CaPaEBR)ebr10996642 035 $a(CaONFJC)MIL785267 035 $a(OCoLC)898102459 035 $a(EXLCZ)993710000000307997 100 $a20150108h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aEnzymes$hVolume thirty-six$iNatural products and cancer signaling : isoprenoids, polyphenols and flavonoids /$fedited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others] 205 $aFirst edition. 210 1$aLondon, [England] :$cAcademic Press,$d2014. 210 4$dİ2014 215 $a1 online resource (279 p.) 225 1 $aEnzymes ;$vVolume 36 300 $aDescription based upon print version of record. 320 $aIncludes bibliographical references at the end of each chapters and indexes. 327 $aFront Cover; The Enzymes: Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids; Copyright; Contents; Contributors; Preface; Chapter One: Introduction; References; Chapter Two: Perillyl Alcohol (Monoterpene Alcohol), Limonene; 1. Introduction; 2. Perillyl Alcohol; 2.1. Perillyl Alcohol Mechanism of Action in Cancer Therapy and Pharmacokinetics; 2.2. Perillyl Alcohol Biosafety and Adverse Effects in Clinical Application and Clinical Trials; 3. Limonene; 3.1. Limonene Pharmacokinetics; 3.2. Limonene Anticancer Activity and Clinical Trials 327 $a3.3. Limonene Mechanisms of Action, Targets, and Clinical Applications3.4. Limonene Biosafety and Adverse Effects; 4. Concluding Remarks; Acknowledgment; References; Chapter Three: Ganoderic Acid and Lucidenic Acid (Triterpenoid); 1. Introduction; 2. Lucidenic Acids and Ganoderic Acids from Ganoderma Species; 2.1. The Sources of Lucidenic Acids and Ganoderic Acids; 2.2. The Biosynthesis of Ganoderic Acids; 2.3. Optimization of the Fermentation Process; 3. Biological Functions of Lucidenic Acids and Ganoderic Acids; 3.1. Cytotoxic and Apoptotic Effects; 3.2. Cell Cycle Arrest 327 $a3.3. Anti-invasive Effect3.4. Autophagy; 3.5. Anti-inflammatory Effect; 3.6. Antiosteoclastogenesis; 3.7. Antiasthma; 3.8. Antihepatitis B Activity; 4. Pharmacokinetics of Ganoderic Acids; 5. Conclusion; References; Chapter Four: Anticancer Effect and Molecular Targets of Saffron Carotenoids; 1. Introduction; 2. Anticancer Effect of Saffron and Its Carotenoids; 3. Comparing the Efficacy of Crocetin, Crocin, and Other Components; 4. Liposome Formulation of Saffron Compounds; 5. Effect of Crocetin and Crocin on Macromolecule Synthesis and Structure 327 $a5.1. Effect on DNA, RNA, and Protein Synthesis5.2. Protein Binding; 6. Effects on Cell Cycle, Apoptosis, and Signaling Pathways; 7. Role of Saffron Components on Chemoprevention; 8. Molecular Mechanisms Involved in the Protective Effect of Saffron Components against Various Damages in Different Tissues; 9. Antioxidant and Anti-inflammatory Effects of Saffron; 10. Safety; 11. Other Mechanisms; 12. Conclusions; References; Chapter Five: Zerumbone from Ginger (Monoterpenoid); 1. Introduction; 2. Characteristic Feature; 3. Target Pathways by Zerumbone; 3.1. Survival; 3.1.1. Caspase Family 327 $a3.1.2. Bcl Family3.1.3. c-FLIP; 3.1.4. G2/M Cell Cycle; 3.2. Proliferation; 3.2.1. Cyclin B1/CDK1; 3.2.2. Tumor Necrosis Factor; 3.3. Invasion; 3.4. Angiogenesis; 4. Nuclear Factor-Kappa B; 5. Future Perspectives; References; Chapter Six: Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer; 1. Introduction; 2. Triterpenoid Saponins in the Prevention and Therapy of Cancers; 3. Anticancer Properties and Molecular Mechanisms of Triterpenoid Saponins; 3.1. Inhibition of Proliferation; 3.2. Induction of Apoptosis and Autophagy; 3.2.1. Apoptosis 327 $a3.2.2. Autophagy 330 $aNatural compounds from a variety of natural resources including plants have emerged as important source of anticancer drug development. This special issue will highlight the significant advance in elucidating mechanisms of action of these natural compounds, focusing especially on isoprenoids and polyphenols/flavonoids.

Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field 410 0$aEnzymes ;$vVolume 36. 606 $aCancer$xAlternative treatment 606 $aCancer$xTreatment 615 0$aCancer$xAlternative treatment. 615 0$aCancer$xTreatment. 676 $a616.994061 702 $aBathaie$b S. Zahra 702 $aTamanoi$b Fuyuhiko 702 $aAlizadeh$b Javad 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910787265603321 996 $aEnzymes$9367093 997 $aUNINA