LEADER 03180oam 2200529I 450 001 9910787243903321 005 20230807212122.0 010 $a0-429-09506-6 010 $a1-4822-6373-4 024 7 $a10.1201/b17795 035 $a(CKB)3710000000280889 035 $a(EBL)1676458 035 $a(SSID)ssj0001368478 035 $a(PQKBManifestationID)11896636 035 $a(PQKBTitleCode)TC0001368478 035 $a(PQKBWorkID)11469193 035 $a(PQKB)11633760 035 $a(MiAaPQ)EBC1676458 035 $a(OCoLC)895661019 035 $a(EXLCZ)993710000000280889 100 $a20180331h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aNatural selection $emethods and applications /$fMario A. Fares, School of Genetics and Microbiology, Department of Genetics, University of Dublin, Trinity College, Dublin, Ireland 210 1$aBoca Raton :$cTaylor & Francis,$d[2015] 210 4$dİ2015 215 $a1 online resource (274 p.) 300 $aA Science Publishers book. 311 $a1-322-63808-X 311 $a1-4822-6372-6 320 $aIncludes bibliographical references at the end of each chapters. 327 $aFront Cover; Dedication; Preface; Contents; CHAPTER 1: The Role of Natural Selection in Evolution; CHAPTER 2: Identifying Evolution Signatures in Molecules; CHAPTER 3: Modeling Evolution of Molecular Sequences; CHAPTER 4: Identifying Natural Selection with Molecular Data; CHAPTER 5: Inferring Functional Divergence in Protein Sequences; Chapter 6: The Influence of Re combination on the Estimation of Selection from Coding Sequence Alignments; Chapter 7: Why Proteins Evolve at Different Rates: The Determinants of Proteins'Rates of Evolution 327 $aChapter 8: The Network Framework of Molecular EvolutionChapter 9: Molecular Coevolution:Methods and Applications; Color Plate Section; Back Cover 330 $aThis book summarizes the knowledge in the field of methods to identify signatures of natural selection. A number of mathematical models and methods have been designed to identify the fingerprints of natural selection on genes and genomes. Such methods are provided in a simple and direct way so that students of different disciplines can navigate through molecular fitness landscapes using complex methods with a basic knowledge on bioinformatics. A collection of the main methods to detect selection in protein-coding genes and amino acid sequences is given at different levels of complexity, from nucleotides to proteins and molecular networks. The importance of identifying natural selection in genes and genomes through the methods described in this book transcends the bioinformatics and computational biology fields, presenting applications for experimental biologists in a straightforward and understandable way--Provided by publisher. 606 $aNucleotides 615 0$aNucleotides. 676 $a547.79 700 $aFares$b Mario A.$01471900 801 0$bFlBoTFG 801 1$bFlBoTFG 906 $aBOOK 912 $a9910787243903321 996 $aNatural selection$93684417 997 $aUNINA