LEADER 04403nam 2200469 450 001 9910787158303321 005 20230803205700.0 010 $a0-309-31230-2 010 $a0-309-31228-0 035 $a(CKB)3710000000260802 035 $a(MiAaPQ)EBC3379364 035 $a(Au-PeEL)EBL3379364 035 $a(CaPaEBR)ebr10951318 035 $a(OCoLC)893439489 035 $a(EXLCZ)993710000000260802 100 $a20141017h20142014 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aReview of the formaldehyde assessment in the National Toxicology Program 12th report on carcinogens /$fNational Research Council (U.S.) ; Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens Board on Environmental Studies and Toxicology Division on Earth and Life Studies 210 1$aWashington, District of Columbia :$cNational Academies Press,$d2014. 210 4$dİ2014 215 $a1 online resource (246 pages) $cillustrations 311 $a0-309-31224-8 311 $a0-309-31227-2 327 $aReview of the Formaldehyde Profile in the National Toxicology Program 12th Report on Carcinogens -- Independent Assessment of Formaldehyde -- Appendix A: Biographic Information on the Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens -- Appendix B: Statement of Task of the Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens -- Appendix C: Exposure Assessment in Epidemiologic Carcinogenicity Studies -- Appendix D: Literature-Search Strategies Completed in Support of the Committee's Independent Assessment of Formaldehyde -- Appendix E: Genotoxicity and Mutagenicity Summary Tables. 330 $a"Many people in the United States are exposed to formaldehyde. Exposure can occur from environmental sources (for example, combustion processes, building materials, and tobacco smoke) or in occupational settings (for example, the furniture, textile, and construction industries). Formaldehyde exposure also has endogenous sources--it is produced intracellularly as a component of the one carbon pool intermediary metabolism pathway. Scientists have studied formaldehyde for decades to determine whether exogenous formaldehyde exposure may be associated with cancer in humans. In 1981, The National Toxicology Program (NTP) first listed formaldehyde in the 2nd Report on Carcinogens as "reasonably anticipated to be a human carcinogen". In 2011, NTP upgraded the listing of formaldehyde to "known to be a human carcinogen". Following the new listing, Congress directed the Department of Health and Human Services to arrange for the National Academy of Sciences to independently review formaldehyde's substance profile and listing. This report presents the findings and conclusions of the committee formed in response to the congressional request. Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens concurs with NTP that there is sufficient evidence in studies that had adequate characterization of relevant exposure metrics to enable a strong conclusion about the association between formaldehyde exposure and cancer in humans. Additionally, the authoring committee independently reviewed the scientific evidence from studies in humans, experimental animals, and other studies relevant to the mechanisms of carcinogenesis and made level-of-evidence conclusions. This report finds clear and convincing epidemiologic evidence of an association between formaldehyde exposure and nasopharyngeal and sinonasal cancers in humans"--$cPublisher's description. 606 $aFormaldehyde$xEnvironmental aspects 606 $aFormaldehyde$xToxicology 615 0$aFormaldehyde$xEnvironmental aspects. 615 0$aFormaldehyde$xToxicology. 676 $a628.532 712 02$aNational Research Council (U.S.).$bCommittee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens, 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910787158303321 996 $aReview of the formaldehyde assessment in the National Toxicology Program 12th report on carcinogens$93791256 997 $aUNINA