LEADER 00949nam0-22003131i-450- 001 990007520870403321 005 20091022143834.0 035 $a000752087 035 $aFED01000752087 035 $a(Aleph)000752087FED01 035 $a000752087 100 $a20030814d1990----km-y0itay50------ba 101 0 $aita 102 $aIT 200 1 $a<>turismo a Rosolina e Albarella$erisorsa o consumo ?$fA. Girardi, L. Carletto. 210 $aPadova$cUniversitą$d1990 215 $a75 p.$d24 cm 225 1 $aQuaderni del Dipartimento di geografia dell'Universitą degli studi di Padova$v10 610 0 $aVeneto$aTurismo 610 0 $aAdriatico$aTurismo 700 1$aGirardi,$bAdolfo$0130227 702 1$aCarletto,$bL. 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990007520870403321 952 $aA-IT 0458$bB.F.L.F.37665$fILFGE 959 $aILFGE 996 $aTurismo a Rosolina e Albarella$9684254 997 $aUNINA LEADER 10966nam 2200541 450 001 9910523003103321 005 20220818173422.0 010 $a3-030-89074-0 035 $a(MiAaPQ)EBC6812175 035 $a(Au-PeEL)EBL6812175 035 $a(CKB)19919158300041 035 $a(OCoLC)1286665759 035 $a(PPN)258839287 035 $a(EXLCZ)9919919158300041 100 $a20220818d2022 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe kappa opioid receptor /$fLee-Yuan Liu-Chen, Saadet Inan, editors 210 1$aCham, Switzerland :$cSpringer,$d[2022] 210 4$d©2022 215 $a1 online resource (574 pages) 225 1 $aHandbook of experimental pharmacology ;$vVolume 271 311 08$aPrint version: Liu-Chen, Lee-Yuan The Kappa Opioid Receptor Cham : Springer International Publishing AG,c2022 9783030890735 320 $aIncludes bibliographical references and index. 327 $aIntro -- Preface -- Contents -- Part I: Basics -- Fundamentals of the Dynorphins/Kappa Opioid Receptor System: From Distribution to Signaling and Function -- 1 Historical Perspectives -- 2 Dynorphin Peptides -- 3 Cloning of the KOR -- 4 Neuroanatomy of the KOR -- 5 KOR Signaling at the Cellular Level -- 6 Agonist-Promoted KOR Phosphorylation and Regulation -- 7 X-ray Crystal Structures of the KOR -- 8 In Vivo Pharmacology of the DYNs/KOR System -- 9 Conclusion -- References -- Considerations on Using Antibodies for Studying the Dynorphins/Kappa Opioid Receptor System -- 1 Introduction -- 2 General Considerations for Validation of Specificity of Antibodies -- 2.1 Unique Issues Associated with Antibodies Against G Protein-Coupled Receptors (GPCRs) -- 2.2 Validation of Specificity of Antibodies -- 3 Antibodies for IHC of the KOR -- 3.1 Characterization of KT2 Antibody and KOR1 Antibodies for IHC -- 3.2 IHC of the KOR in the Brain -- 3.3 Generation of a Mouse Line Expressing a Fusion Protein of the KOR Conjugated with tdTomato (KOR-tdT) -- 4 KOR Antibodies for IB -- 4.1 Detection of KOR Expressed in Cells -- 4.2 Detection of the KOR in Mouse Brains -- 5 Antibodies for IB of Phosphorylated KOR -- 5.1 Detection of Phosphorylated KOR in Cells -- 5.2 Detection of Phosphorylated KOR in Mouse Brains -- 5.3 U50,488H Promoted KOR Phosphorylation at T363 and S369 in Mouse Brains in a Dose-Dependent Manner -- 6 KOR Antibodies from Commercial Sources -- 7 Antibodies against Dynorphins: Some Considerations -- 8 Conclusion -- References -- Part II: In Vitro Studies -- Structural Characterization of KOR Inactive and Active States for 3D Pharmacology and Drug Discovery -- 1 Introduction -- 2 Structure Determination of KOR -- 2.1 KOR-JDTic Structure in Inactive State -- 2.2 KOR-MP1104 Structure in Active State -- 2.3 JDTic-KOR-Nb6 Structure in Inactive State. 327 $a3 Overall Architecture of the KOR in Inactive and Active States -- 4 Structural Determinants of Long-Acting Antagonist JDTic Binding in Inactive Structure -- 5 Structural Determinants of Agonist MP1104 Binding in the Active-State Structure -- 6 Large-Scale Conformational Changes in KOR as a Part of the Activation Mechanism -- 7 Structure-Based Insights into KOR 3D Pharmacology -- 7.1 KOR Antagonists: Long-Acting and Short-Acting -- 7.2 KOR Agonists -- 7.3 Determinants of Opioid Ligand Selectivity at KOR -- 8 Applications of KOR Structure to Computer-Assisted Ligand Discovery -- 8.1 Understanding KOR Dynamics by MD Simulations -- 8.2 Discovery of New KOR Chemotypes by Structure-Based Virtual Screening -- 8.3 Rational Design for KOR Selectivity Over MOR and DOR -- 8.4 Rational Design for KOR Functional Selectivity -- 9 Conclusions and Outlook -- References -- Biosensors Monitor Ligand-Selective Effects at Kappa Opioid Receptors -- 1 Introduction: Ligand-Selective Effects at the Kappa Opioid Receptor -- 2 Nanobodies and Mini-G Proteins Act as Conformation-Specific KOR Binders -- 2.1 Active State Binding Nanobodies Nb39 and Nb33 -- 2.2 Inactive State Binding Nanobody Nb6 -- 2.3 Active State Binding Mini-G Protein Mini-Gsi -- 3 Biosensors Robustly and Rapidly Report on KOR Activation and Deactivation -- 4 Biosensors Reveal Ligand-Selective Effects at KOR -- 4.1 Ligand-Selective Recruitment of Distinct Biosensors to KOR -- 4.2 Agonist-Selective Activation of KOR at Distinct Cellular Locations -- 5 Conclusions and Outlook -- References -- Does GEC1 Enhance Expression and Forward Trafficking of the Kappa Opioid Receptor (KOR) via Its Ability to Interact with NSF D... -- 1 Introduction -- 2 Experimental Procedures -- 2.1 Pull-Down Assays Using Purified Recombinant Proteins Expressed in E. coli -- 3 Results -- 4 Discussion -- References. 327 $aKappa Opioid Receptor Mediated Differential Regulation of Serotonin and Dopamine Transporters in Mood and Substance Use Disord... -- 1 Introduction -- 2 KOR and the Serotonergic System -- 2.1 KOR Interaction with Serotonergic System and Its Relevance to Psychiatric Disorders -- 2.2 KOR Signaling in the Regulation of Serotonin Clearance: Modulation of Serotonin Transporter Function, Trafficking, and Pho... -- 3 KOR and the Dopaminergic System -- 3.1 KOR Interaction with Dopaminergic System and Its Relevance to Cocaine Use Disorder -- 3.2 KOR Signaling in the Regulation of Dopamine Clearance: Modulation of Dopamine Transporter Function and Trafficking -- 4 Dynorphin/KOR System as a Therapeutic Target -- 5 Conclusions -- References -- Part III: Preclinical Drug Development -- Biased Ligands at the Kappa Opioid Receptor: Fine-Tuning Receptor Pharmacology -- 1 Introduction: Biased Signaling and the Kappa Opioid Receptor -- 2 Signaling Cascades Downstream of the Kappa Opioid Receptor -- 2.1 G Proteins -- 2.2 ?arrestin2 Activation -- 3 Physiological Implications of Signaling Pathways Downstream of the Kappa Opioid Receptor -- 4 Biased Ligands at the Kappa Opioid Receptor -- 5 Conclusions -- References -- Preclinical Studies on Nalfurafine (TRK-820), a Clinically Used KOR Agonist -- 1 Introduction -- 2 In Vitro Pharmacological Characterization of Nalfurafine -- 2.1 Bioassays -- 2.2 Binding Affinity and Selectivity Profile of Nalfurafine at MOR, DOR, KOR and NOR -- 2.3 No Significant Binding to Targets Other Than Opioid Receptors -- 2.4 Efficacies and Potencies of Nalfurafine in Activating MOR, DOR, KOR and NOR: Inhibition of Adenylate Cyclase and Enhanceme... -- 2.5 Functional Selectivity of Nalfurafine in KOR-Mediated Activation of G Proteins and ?-Arrestins -- 2.6 KOR Internalization and Down-Regulation -- 3 In Vivo Pharmacological Effects of Nalfurafine. 327 $a3.1 Antipruritic Effects -- 3.2 Anti-nociceptive Effects -- 3.3 Anti-allodynic and Anti-hyperalgesic Effects -- 3.4 Inhibition of Neurogenic Inflammation -- 3.5 Aversive Effects or Lack Thereof -- 3.6 Effects on Locomotor Activity and Motor Coordination -- 3.7 Water Diuretic Effects -- 3.8 Nalfurafine and U50,488H Induced Different Phosphoproteomic Changes in Mouse Brains -- 3.9 Effect of Nalfurafine on Pharmacological Actions of Morphine -- 3.9.1 Effects on Morphine-Induced Itch -- 3.9.2 Effect on Morphine-Induced Antinociception -- 3.9.3 Effects on Rewarding Properties of Morphine and Oxycodone -- 3.9.4 Effects on Morphine-Induced Tolerance and Dependence -- 3.9.5 Effects on Morphine-Induced Hyperlocomotion -- 4 Nalfurafine as an Abuse-Deterring Agent for Prescription Opioid Abuse -- 4.1 Translational Significance of Contingent vs. Non-contingent Administration of KOR Agonists -- 4.2 Behavioral Pharmacology of Nalfurafine/Oxycodone Combinations -- 4.2.1 Studies in Rats -- 4.2.2 Studies in Nonhuman Primates -- 5 Effects of Nalfurafine on Alcohol Drinking -- 5.1 The Dynorphins/KOR System in Alcohol-Related Behaviors -- 5.2 Development of Nalfurafine as a Potential Therapeutic Agent for Alcoholism -- 6 Effect of Nalfurafine on CPP and Discriminative Stimulus Effects of Cocaine -- 7 Other Effects -- 8 Conclusion -- References -- Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Li... -- 1 Introduction -- 2 KOR Ligands and Their Pharmacology -- 2.1 Natural Ligands -- 2.2 Synthetic Ligands -- 2.3 Diphenethylamines, a New Class of Selective KOR Ligands -- 2.3.1 Agonists and Partial Agonists -- 2.3.2 Biased Agonists -- 2.3.3 Antagonists -- 2.3.4 In Vivo Pharmacology -- 3 Conclusion -- References -- Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug Development. 327 $a1 Introduction -- 1.1 Actions of the Endogenous Kappa Opioid System and Resultant Potential Therapeutic Applications of Ligands for Kappa Opioid... -- 1.2 Review of Key Non-Peptidic Kappa Opioid Receptor-Selective Ligands -- 2 Peptide Ligands for Kappa Opioid Receptors -- 2.1 Dynorphin A Analogs -- 2.2 Tetrapeptide KOR Ligands -- 2.2.1 All-D-Amino Acid Peptides -- 2.2.2 Endomorphin-1 Derivative -- 2.2.3 Macrocyclic Tetrapeptides -- 3 Conclusions -- References -- Part IV: Preclinical Studies: In Vivo Pharmacology -- Dynorphin/Kappa-Opioid Receptor System Modulation of Cortical Circuitry -- 1 Introduction -- 1.1 Cortical Circuits -- 1.2 Anatomy of the Cortical DYN/KOR System -- 1.3 Function of the DYN/KOR System in the Cortex -- 1.4 Behavioral Effects of the DYN/KOR System in the Cortex -- 1.5 Implication for Human Health and Diseases -- 1.6 Unknowns and Future Directions for the Field -- 1.6.1 DYN/KOR Regulation of Dendritic Integration -- 1.6.2 Conservation Across Species -- 1.6.3 Site of Psychotomimetic Effects -- 1.6.4 Interactions with Other Stress-Related Peptides/Systems -- 1.6.5 Novel Approaches to Study the DYN/KOR System -- 2 Conclusions -- References -- Molecular Genetics of Kappa Opioids in Pain and Itch Sensations -- 1 The Kappa Opioid System in Pain -- 1.1 Peripheral Effects of Dynorphins (DRG and TG Neurons) -- 1.2 Dynorphin Neurons in the Spinal Cord -- 1.3 Functions of the Dynorphin/KOR System in the Parabrachial Nucleus -- 1.4 Role of Kappa Opioids in Pain-Induced Stress Responses in the Dorsal Raphe Nucleus, Amygdala, Rostral Ventral Medulla, and... -- 1.5 Summary and Future Direction of Kappa Signaling in Control of Pain -- 2 Kappa Opioids in Itch -- 2.1 Dynorphin Spinal Cord Interneurons Inhibit Itch -- 2.2 Neuronal Circuits for Itch -- 2.3 Summary and Future Direction for Itch Research. 327 $a3 Common Mechanisms of Action of the Kappa Opioid System. 410 0$aHandbook of experimental pharmacology ;$vVolume 271. 606 $aOpioids$xReceptors 606 $aPharmacology 615 0$aOpioids$xReceptors. 615 0$aPharmacology. 676 $a615.7822 702 $aLiu-Chen$b Lee-Yuan 702 $aInan$b Saadet 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910523003103321 996 $aKappa opioid receptor$92966973 997 $aUNINA LEADER 05203nam 2200733 450 001 9910786775603321 005 20200520144314.0 010 $a1-78238-372-7 024 7 $a10.1515/9781782383727 035 $a(CKB)3710000000203704 035 $a(EBL)1420463 035 $a(OCoLC)884645694 035 $a(SSID)ssj0001289818 035 $a(PQKBManifestationID)11715939 035 $a(PQKBTitleCode)TC0001289818 035 $a(PQKBWorkID)11234267 035 $a(PQKB)11639564 035 $a(MiAaPQ)EBC1420463 035 $a(Au-PeEL)EBL1420463 035 $a(CaPaEBR)ebr10899229 035 $a(CaONFJC)MIL633387 035 $a(OCoLC)885470209 035 $a(DE-B1597)636243 035 $a(DE-B1597)9781782383727 035 $a(EXLCZ)993710000000203704 100 $a20140810h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSustainable development $ean appraisal focusing on the Gulf Region /$fedited by Paul Sillitoe ; foreword, Sheikha Al-Misnad 210 1$aNew York ;$aOxford, [England] :$cBerghahn Books,$d2014. 210 4$d©2014 215 $a1 online resource (572 p.) 225 1 $aStudies in Environmental Anthropology and Ethnobiology ;$vVolume 19 300 $aDescription based upon print version of record. 311 $a1-78238-371-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aContents; Illustrations; Foreword; Introduction - Sustainable Development in the Gulf; Chapter 1 - Societal Change and Sustainability within the Central Plateau of Iran: An Archaeological Viewpoint; Part 1 - Planning Sustainable Development; Chapter 2 - Qatar National Vision 2030: Advancing Sustainable Development; Chapter 3 - The Qatar National Master Plan; Chapter 4 - The State of Qatar: Along the Way to Sustainable Development; Chapter 5 - Charting the Emergence of Environmental Legislation in Qatar: A Step in the Right Direction or Too Little Too Late? 327 $aPart II - Energy and Economic IssuesChapter 6 - Sustainable Energy: What Futures for Qatar?; Chapter 7 - Money Rain: The Resource Curse in Two Oil and Gas Economies; Chapter 8 - Islam and Sustainable Economic Development; Part III - Environmental Issues; Chapter 9 - Linking Local and Global in the Sustainable Development of Biodiversity Conservation; Chapter 10 - Conservation and Sustainable Development: The Qatari and Gulf Region Experience; Chapter 11 - Promoting Sustainable Development in Marine Regions; Chapter 12 - Biodiversity Conservation and Sustainability: Friends or Enemies? 327 $aPart IV: Urban and Health IssuesChapter 13 - From Pearling to Skyscrapers: The Predicament of Sustainable Architecture and Urbanism in Contemporary Gulf Cities; Chapter 14 - How the City Grows: Urban Growth and Challenges to Sustainable Development in Doha, Qatar; Chapter 15 - Sustainable Waste Management in Qatar: Charting the Emergence of an Integrated Approach to Solid Waste Management; Chapter 16 - Sustainable Development and Health: From Global to Local Agenda; Part V - Cultural and Social Issues 327 $aChapter 17 - Exploring Collaborative Research Methodologies in the Pursuit of Sustainable FeaturesChapter 18 - On the Importance of Culture in Sustainable Development; Chapter 19 - People, Social Groups, Cultural Practices: From Venn Diagrams to Alternative Paradigms for Sustainable Development; Chapter 20 - Contradictory Forces in the Gulf Environment: Old and New Cultural Values and Knowledge; Conclusion - A Doha Undeclaraton, Puzzling over Sustainable Development with Indigenous Knowledge; Notes on Contributors; Index 330 $a With growing evidence of unsustainable use of the world's resources, such as hydrocarbon reserves, and related environmental pollution, as in alarming climate change predictions, sustainable development is arguably the prominent issue of the 21st century. This volume gives a wide ranging introduction focusing on the arid Gulf region, where the challenges of sustainable development are starkly evident. 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