LEADER 03555nam 2200553Ia 450 001 9910786740103321 005 20230803030028.0 010 $a0-19-933987-2 010 $a0-19-986108-0 035 $a(CKB)2670000000357794 035 $a(StDuBDS)AH25206773 035 $a(SSID)ssj0000885909 035 $a(PQKBManifestationID)12404907 035 $a(PQKBTitleCode)TC0000885909 035 $a(PQKBWorkID)10814421 035 $a(PQKB)11719382 035 $a(MiAaPQ)EBC1164112 035 $a(Au-PeEL)EBL1164112 035 $a(CaPaEBR)ebr10703944 035 $a(CaONFJC)MIL491332 035 $a(OCoLC)922904514 035 $a(EXLCZ)992670000000357794 100 $a20130404h20132013 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCrucible of science$b[electronic resource] $ethe story of the Cori laboratory /$fJohn H. Exton 210 $aOxford $cOxford University Press$dc2013 215 $a1 online resource (xvi, 226 pages ) $cillustrations 300 $aFormerly CIP.$5Uk 311 $a0-19-986107-2 320 $aIncludes bibliographical references and index. 330 8 $aThis title examines the careers of Carl and Gerty Cori, and the other eminent scientists who trained in their laboratory.$b"Crucible of Science" is the story of a unique laboratory at Washington University in St. Louis, and of Carl and Gerty Cori, the biochemists who established it. Carl and Gerty met and married at medical school in Prague in the 1920s. After graduation, they immigrated to the U.S. to escape deteriorating conditions in Europe. Carl soon received an offer from Washington University to become Pharmacology Chair, and the couple settled in St. Louis. Not only did both Coris go on to winthe Nobel Prize, the laboratory they established at the University has since produced some of the most outstanding scientists the U.S. has ever seen. Six laboratory scientists also won Nobel Prizes; few, if any, laboratories can claim such an impressive record. The Coris themselves were instrumental inestablishing the then new science of Biochemistry in the U.S. They applied chemical approaches to elucidating the transformations of compounds such as glucose in animal tissues and defined the enzyme catalysts that carried out those transformations. Both scientists were extremely rigorous in designing their experiments and interpreting the results, a habit that ensured their findings were above question. This book examines the careers of both Coris and the other eminent scientists who trained in their laboratory. It notes the Coris' acceptance of women, Jews, and scientists from all over the world, unique during this time period. It analyzes those reasons why the laboratory was so successful in attracting the best trainees and producing premier scientists. Intended for scientists, science historians, and anyone interested in the history of science, "Crucible of Science" is a unique presentationof remarkable careers and personalities, examined within the context of the Coris' laboratory. 606 $aBiochemists$zUnited States$vBiography 606 $aMedicine$xResearch$zMissouri$zSaint Louis 615 0$aBiochemists 615 0$aMedicine$xResearch 676 $a572.092/2778 676 $aB 700 $aExton$b John H$g(John Howard),$f1933-$01493328 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910786740103321 996 $aCrucible of science$93716262 997 $aUNINA