LEADER 03929nam 22006134a 450 001 9910777859203321 005 20230607222007.0 010 $a1-281-73045-9 010 $a9786611730451 010 $a0-300-12966-1 024 7 $a10.12987/9780300129663 035 $a(CKB)1000000000471991 035 $a(StDuBDS)BDZ0022171458 035 $a(SSID)ssj0000201499 035 $a(PQKBManifestationID)11184383 035 $a(PQKBTitleCode)TC0000201499 035 $a(PQKBWorkID)10245497 035 $a(PQKB)11781868 035 $a(StDuBDS)EDZ0000158001 035 $a(MiAaPQ)EBC3420064 035 $a(DE-B1597)485546 035 $a(OCoLC)1024032087 035 $a(DE-B1597)9780300129663 035 $a(Au-PeEL)EBL3420064 035 $a(CaPaEBR)ebr10170754 035 $a(OCoLC)923589373 035 $a(EXLCZ)991000000000471991 100 $a20010123d2001 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMeselson, Stahl, and the replication of DNA$b[electronic resource] $ea history of "the most beautiful experiment in biology" /$fFrederic Lawrence Holmes 210 $aNew Haven, CT $cYale University Press$d2001 215 $a1 online resource (1 online resource (xii, 503 p.) ) $cill 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-300-08540-0 320 $aIncludes bibliographical references (p. [449]-496) and index. 327 $aMachine generated contents note: Chapter One The Replication Problem 11 -- Chapter Two Meselson and Stahl 49 -- Chapter Three Twists and Turs 75 -- Chapter Four Crossing Fields: Chemical Bonds to Biological Mutants 116 -- Chapter Five Dense Solutions 157 -- Chapter Six The Big Machine 183 -- Chapter Seven Working at High Speed 215 -- Chapter Eight The Unseen Band 272 -- Chapter Nine One Discovery, Three Stories 303 -- Chapter Ten An Extremely Beautiful Experiment 319 -- Chapter Eleven Centrifugal Forces 352 -- Chapter Twelve The Subunits of Semiconservative Replication 388 -- Chapter Thirteen Images of an Experiment 412 -- Chapter Fourteen Afterword 435. 330 $aIn 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest.This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment. 606 $aDNA replication$xExperiments$xHistory 606 $aMolecular biology$xExperiments$xHistory 615 0$aDNA replication$xExperiments$xHistory. 615 0$aMolecular biology$xExperiments$xHistory. 676 $a572.8/6 700 $aHolmes$b Frederic Lawrence$0726772 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910777859203321 996 $aMeselson, Stahl, and the replication of DNA$93716347 997 $aUNINA LEADER 03978nam 2200565 450 001 9910786645303321 005 20191118111955.0 010 $a0-85772-377-4 010 $a0-7556-0365-6 010 $a0-85773-476-8 024 7 $a10.5040/9780755603657 035 $a(CKB)3710000000138601 035 $a(EBL)1715014 035 $a(OCoLC)881606945 035 $a(MiAaPQ)EBC1715014 035 $a(CaBNVSL)mat55603657 035 $a(OCoLC)1128176429 035 $a(CaBNVSL)9780755603657 035 $a(Au-PeEL)EBL1715014 035 $a(EXLCZ)993710000000138601 100 $a20191118d2019 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aPain in the arts /$fJohn Tusa 205 $aFirst edition. 210 1$aLondon, England :$cI.B. Tauris,$d2019. 210 2$a[London, England] :$cBloomsbury Publishing,$d2019. 215 $a1 online resource (398 p.) 300 $aIncludes index. 311 $a1-78076-817-6 327 $aPreface -- Part One: Getting Things Done -- Introduction to Part One -- Ch 1 Pain in the Arts: Decline or Renewal -- Ch 2 Surviving the Downturn -- Ch 3 The Case for the Arts -- Ch 4 Mind your Language - Alphabets of Abomination -- Ch 5 Learning on the Job - A Personal Road to Responsibility -- Ch 6 The Do's and Don'ts of Running the Arts -- Ch 7 The Leader, the Manager - What's the Difference? -- Ch 8 What do you Know? - Inside the Mind of a Leader -- Ch 9 An Arts Policy for a Floating Utopia -- Ch 10 Keeping Things Simple -- Part Two: -- Arguing for the Arts -- Ch 11 Introduction to Part Two -- Ch 12 'If Music is the Staff of Life, Play Up!': Who is Playing Whom? -- Ch 13 The Great Arts Education Debate: Slam the Door on the Past - Betray the Future -- Ch 14 A Special Case for Treatment: Special Pleading for the Arts -- Ch 15 The Arts and Civil Society: Standing Up to the Stand Off-ish -- Ch 16 The Arts and Humanities: Defending the Undefendable -- Ch 17 An Agenda for the Future: Making the Arts Matter -- Index. 330 $aOver a distinguished career in cultural leadership, management and journalism spanning almost 30 years, John Tusa has amassed a unique experience of the arts world, the political controversies it faces and the battles it continues to fight. His new book is a fearless and passionate defense of the performing and visual arts at a time of increasing 'Pain in the Arts'. Tusa addresses the controversies in the arts that must be resolved so urgently today, including the ever-flowing arguments on whether they should be useful before they are excellent. He gives guidance on how the arts can survive in the downturn and explains why the case must always be made that they deserve special treatment. He writes an excoriating critique of the language of Whitehall bureaucracy and shows how crucial to the nation's health and wealth are the small regional arts projects alongside our big arts institutions like the Barbican or National Theatre. He also draws on his expertise as Chair of the Clore Leadership Programme to discuss those increasingly complex questions - practical, personal, professional - that today's and tomorrow's cultural leaders must face, including the qualities of character needed to succeed and what a revolution in arts leadership might achieve. The backdrop throughout is Tusa's personal story of discovery and love of the culture he strives to defend in hard times. 606 $aArt and state$zGreat Britain 606 $aArts$zGreat Britain$xManagement 606 $aArt styles not defined by date$2bicssc 615 0$aArt and state 615 0$aArts$xManagement. 615 7$aArt styles not defined by date 676 $a700.68 700 $aTusa$b John$0501686 801 0$bYDXCP 801 1$bCaBNVSL 801 2$bCaBNVSL 906 $aBOOK 912 $a9910786645303321 996 $aPain in the arts$93836071 997 $aUNINA