LEADER 04604nam 2200637Ia 450 001 9910786435603321 005 20230801225804.0 010 $a1-283-85672-7 010 $a3-11-027613-5 024 7 $a10.1515/9783110276138 035 $a(CKB)2670000000309315 035 $a(EBL)893337 035 $a(OCoLC)821198728 035 $a(SSID)ssj0000787604 035 $a(PQKBManifestationID)12342800 035 $a(PQKBTitleCode)TC0000787604 035 $a(PQKBWorkID)10817074 035 $a(PQKB)10882884 035 $a(MiAaPQ)EBC893337 035 $a(DE-B1597)174937 035 $a(OCoLC)823717685 035 $a(OCoLC)853260920 035 $a(DE-B1597)9783110276138 035 $a(Au-PeEL)EBL893337 035 $a(CaPaEBR)ebr10634499 035 $a(CaONFJC)MIL416922 035 $a(EXLCZ)992670000000309315 100 $a20121216d2012 uy 0 101 0 $aeng 135 $aurnn#---|u||u 181 $ctxt 182 $cc 183 $acr 200 00$aExtracorporeal photopheresis$b[electronic resource] $ecellular photoimmunotherapy /$fedited by Hildegard Greinix and Robert Knobler 210 $aBerlin ;$aBoston $cDe Gruyter$dc2012 215 $a1 online resource (228 p.) 300 $aDescription based upon print version of record. 311 0 $a3-11-027594-5 320 $aIncludes bibliographical references. 327 $tFront matter --$tPreface --$tContent --$tAuthors Index --$tSection 1: History of Extracorporeal Photopheresis /$rKnobler, Robert --$tSection 2: Technical Aspects /$rJacobsohn, David / Wong, Edward / Worel, Nina / Hölig, Kristina / Bohbot, Alain / Liu, Vincent / Lioure, Bruno / Bilger, Karin / Laplace, Annegret / Herbrecht, Raoul --$tSection 3: Mechanisms of Action of ECP /$rFerrara, James LM / Schwarz, Thomas / Gatza, Erin / Taylor, Peter C. / Whittle, Rob M. --$tSection 4: Extracorporeal Photopheresis in Acute Graft-versus-Host Disease /$rGreinix, Hildegard T. / Bacigalupo, Andrea --$tSection 5: Extracorporeal Photopheresis in Chronic Graft-versus-Host Disease /$rFlowers, Mary E.D. / Inamoto, Yoshiro / Jagasia, Madan / Raj, Kavita / Das-Gupta, Emma / Couriel, Daniel / Zureki, Kari / Greinix, Hildegard T. --$tSection 6: ECP for the Prevention of Graft-versus-Host Disease /$rLevine, John E. / Kitko, Carrie --$tSection 7: ECP in Cutaneous T Cell Lymphoma /$rScarisbrick, Julia --$tSection 8: ECP in Scleroderma and Other Skin Diseases /$rJust, Ulrike --$tSection 9: ECP in Crohn's Disease /$rReinisch, Walter --$tSection 10: Extracorporeal Photopheresis after Solid Organ/Tissue Transplantation /$rZic, John A. / Michallet, Mauricette / Sobh, Mohamad --$tSection 11: ECP in Diabetes Mellitus /$rBerlin, Gösta / Ludvigsson, Johnny --$tSection 12: Side Effects of Extracorporeal Photopheresis /$rHillen, Uwe --$tSection 13: Summary /$rGreinix, Hildegard T. 330 $aExtracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer, namely cutaneous T-cell lymphoma, and has demonstrated efficacy in various diseases that have a suspected involvement of pathogenic T-cells including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, selected autoimmune diseases and Sezary syndrome. In ECP, patient's blood mononuclear cells are collected, exposed to ultraviolet light in the presence of extracorporeally administered liquid 8-methoxypsoralen and reinfused. Besides its considerable efficacy ECP has an exceptional safety profile, does not cause general immunosuppression and thus, does not increase risk of infectious complications and relapse of malignant disease. Exciting preclinical data and clinical observations provide insight into the mechanisms of action of ECP and support its immunomodulatory role. This book will provide an overview on the historical development of ECP, technical aspects for its use in various patient populations including children and adults, novel research findings both in preclinical models and in various patient cohorts and will stimulate further research in organ, tissue and cell transplantation and autoimmune disorders. 606 $aPhotochemotherapy 606 $aCancer$xTreatment 615 0$aPhotochemotherapy. 615 0$aCancer$xTreatment. 676 $a615.5/8 676 $a615.831 701 $aGreinix$b Hildegard T$01575493 701 $aKnobler$b Robert$01575494 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910786435603321 996 $aExtracorporeal photopheresis$93852499 997 $aUNINA