LEADER 03172nam 2200589Ia 450 001 9910786355203321 005 20230919234413.0 010 $a1-84755-770-8 035 $a(CKB)2670000000276250 035 $a(EBL)1185544 035 $a(SSID)ssj0000755768 035 $a(PQKBManifestationID)11440209 035 $a(PQKBTitleCode)TC0000755768 035 $a(PQKBWorkID)10732643 035 $a(PQKB)11735080 035 $a(MiAaPQ)EBC1185544 035 $a(Au-PeEL)EBL1185544 035 $a(CaPaEBR)ebr10618749 035 $a(CaONFJC)MIL871916 035 $a(OCoLC)232639136 035 $a(PPN)19846777X 035 $a(EXLCZ)992670000000276250 100 $a20080204h20072007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFreeze-drying of pharmaceuticals and biopharmaceuticals $e[principles and practice] /$fFelix Franks ; in association with Tony Auffret 210 1$aCambridge :$cRSC Publishing,$d2007. 210 4$aŠ2007 215 $a1 online resource (xii, 206 pages) $cillustrations 300 $aDescription based upon print version of record. 311 0 $a0-85404-151-6 320 $aIncludes bibliographical references (p. 190-200) and index. 330 $aFreeze-drying, in the past popular in the food industry, has more recently been adopted by the pharmaceutical industry as a standard method for the production of stable solid preparations. Freeze-drying of Pharmaceuticals and Biopharmaceuticals is the first book to specifically describe this process, as related to the pharmaceutical industry. The emphasis of this book is on the properties of the materials processed, how effective formulations are arrived at, and how they are stored and marketed. Beginning with a historical overview of the process, Freeze-drying of Pharmaceuticals and Biopharmaceuticals briefly describes the processes and equipment involved, including: the physics, chemistry and biochemistry associated with freezing, aspects of formulation development, primary and secondary drying; the economics and engineering of scaling up; and, most importantly, attributes of the dried product. It also discusses in detail the science behind freeze-drying, such as the properties of crystalline and amorphous solids. The book concludes with selected case studies and discusses the future of freeze-drying, advances in alternative drying methods, and concludes with an extensive bibliography. This book, written by a leading expert in the field, is aimed primarily at product and process developers in the biopharmaceutical industry and academia. 606 $aFrozen drugs 606 $aFreeze-drying 606 $aBiopharmaceutics 615 0$aFrozen drugs. 615 0$aFreeze-drying. 615 0$aBiopharmaceutics. 676 $a615.18 700 $aFranks$b Felix$018323 701 $aAuffret$b Tony$01570002 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910786355203321 996 $aFreeze-drying of pharmaceuticals and biopharmaceuticals$93843348 997 $aUNINA