LEADER 04320oam 2200637I 450 001 9910786226803321 005 20200520144314.0 010 $a0-429-09612-7 010 $a1-4665-1479-5 024 7 $a10.1201/b14075 035 $a(CKB)2670000000342246 035 $a(EBL)1165895 035 $a(SSID)ssj0000855870 035 $a(PQKBManifestationID)11488165 035 $a(PQKBTitleCode)TC0000855870 035 $a(PQKBWorkID)10805293 035 $a(PQKB)10497610 035 $a(Au-PeEL)EBL1165895 035 $a(CaPaEBR)ebr10681944 035 $a(CaONFJC)MIL501708 035 $a(OCoLC)839676912 035 $a(OCoLC)841908981 035 $a(CaSebORM)9781466514799 035 $a(MiAaPQ)EBC1165895 035 $a(EXLCZ)992670000000342246 100 $a20180331d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCellular potts models $emultiscale extensions and biological applications /$fMarco Scianna and Luigi Preziosi 205 $a1st edition 210 1$aBoca Raton :$cCRC Press,$d2013. 215 $a1 online resource (300 p.) 225 1 $aChapman & Hall/CRC mathematical and computational biology series 300 $a"A Chapman & Hall book." 311 $a1-4665-1478-7 320 $aIncludes bibliographical references. 327 $aFront Cover; Contents; Preface; Part 1: Basic Cellular Potts Model and Applications; Chapter 1: Basic CPM; Chapter 2: HGF-Induced Cell Scatter; Chapter 3: Mesothelial Invasion of Ovarian Cancer; Part II: Extended Cellular Potts Model and Applications; Chapter 4: Extended Cellular Potts Model; Chapter 5: Wound Healing Assay; Chapter 6: Effect of Calcium-Related Pathways on Single Cell Motility; Chapter 7: Tumor-Derived Vasculogenesis; Chapter 8: Different Morphologies of Tumor Invasion Fronts; Chapter 9: Cell Migration in Extracellular Matrices 327 $aChapter 10: Cancer Cell Migration in Matrix MicrochannelsPart III: Appendix; Appendix A: Computational Implementation; Appendix B: Glossary; Appendix C: Parameter Values; Appendix D: Color Insert; Bibliography 330 $aAll biological phenomena emerge from an intricate interconnection of multiple processes occurring at different levels of organization: namely, at the molecular, the cellular and the tissue level, see Figure 1. These natural levels can approximately be connected to a microscopic, mesoscopic, and macroscopic scale, respectively. The microscopic scale refers to those processes that occur at the subcellular level, such as DNA synthesis and duplication, gene dynamics, activation of receptors, transduction of chemical signals, diffusion of ions and transport of proteins. The mesoscopic scale, on the other hand, can refer to cell-level phenomena, such as adhesive interactions between cells or between cells and ECM components, cell duplication and death and cell motion. The macroscopic scale finally corresponds to those processes that are typical of multicellular behavior, such as population dynamics, tissue mechanics and organ growth and development. It is evident that research in biology and medicine needs to work in a multiscale fashion. This brings many challenging questions and a complexity that can not be addressed in the classical way, but can take advantage of the increasing collaboration between natural and exact sciences (for more detailed comments the reader is referred to [90, 262]). On the other hand, the recent literature provides evidence of the increasing attention of the mathematical, statistical, computational and physical communities toward biological and biomedical modeling, consequence of the successful results obtained by a multidisciplinary approach to the Life Sciences problems--$cProvided by publisher. 410 0$aChapman and Hall/CRC mathematical & computational biology series. 606 $aBiology$xMathematical models 615 0$aBiology$xMathematical models. 676 $a519.23 686 $aMAT003000$aMED009000$aSCI055000$2bisacsh 700 $aScianna$b Marco.$01541884 701 $aPreziosi$b Luigi$032041 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910786226803321 996 $aCellular potts models$93794262 997 $aUNINA