LEADER 05137nam 2200661 a 450 001 9910785961803321 005 20210618110339.0 010 $a1-283-70649-0 010 $a0-12-387838-1 035 $a(CKB)2670000000268702 035 $a(EBL)1048862 035 $a(OCoLC)818867523 035 $a(SSID)ssj0000796819 035 $a(PQKBManifestationID)12317408 035 $a(PQKBTitleCode)TC0000796819 035 $a(PQKBWorkID)10799721 035 $a(PQKB)11324603 035 $a(Au-PeEL)EBL1048862 035 $a(CaPaEBR)ebr10617468 035 $a(CaONFJC)MIL401899 035 $a(MiAaPQ)EBC1048862 035 $a(PPN)193094029 035 $a(EXLCZ)992670000000268702 100 $a20121107d2013 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPlatelets$b[electronic resource] /$feditor, Alan D. Michelson 205 $a3rd ed. 210 $aAmsterdam $cElsevier$d2013 215 $a1 online resource (1398 p.) 300 $aDescription based upon print version of record. 311 $a0-12-387837-3 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Platelets; Copyright Page; Contents; List of Contributors; Preface; Foreword: A Brief History of Ideas About Platelets in Health and Disease; I. The Role of Platelets in Human Hemostasis, Platelet Transfusion, and the Bleeding Time; II. Immune Thrombocytopenia; III. Alloantigens, Single Nucleotide Polymorphisms, and Alloimmune Thrombocytopenias; IV. Platelet Physiology, Assays of Platelet "Adhesiveness", ADP, Platelet Aggregation, Myocardial Infarction, and P2Y12 Anta... 327 $aV. Aspirin, Arachidonic Acid, Prostaglandins, Gpiib-iiia, Nitric Oxide, Endothelial Gpiib-iiia, and AngiogenesisVI. Clot Retraction, Glanzmann Thrombasthenia, GPIIb-IIIa Receptor, and GPIIb-IIIa Antagonists; VII. Bernard-Soulier Syndrome, the Gpib-IX-V Complex, von Willebrand Factor, Shear, ADAMTS-13, and Thrombotic Thrombocytopen...; VIII. Thrombin-induced Platelet Activation; IX. Platelets and Metastases; X. Reflections on the Past and Thoughts About the Future; Reference List; I. Platelet Biology; 1 The Evolution of Mammalian Platelets; I Introduction; II Invertebrates 327 $aIII Nonmammalian VertebratesIV Comparative Hemostasis; V A Comparison of Human Platelets and Limulus Amebocytes; VI The Evolution of Hemostasis and Blood Coagulation; VII Megakaryocytes and Mammals; A Marine Mammals; B Order Monotremata; C Order Marsupialia; D Platelet Levels; E A Comparison of Nonplacental and Placental Mammals; VIII Conclusions; Acknowledgments; References; 2 Megakaryocyte Development and Platelet Formation; I Introduction; II Megakaryocyte Development; A The Hematopoietic Program; B Committed Megakaryocyte Progenitor Cells; C Immediate Megakaryocyte Precursors 327 $aD Endomitosis and Polyploid Formation E Megakaryocyte Cytoplasmic Maturation; 1 Demarcation Membrane System; 2 Dense Tubular System; 3 Granules; III Platelet Formation; A Mechanisms of Platelet Production; 1 Budding from the Megakaryocyte Surface; 2 Cytoplasmic Fragmentation via the Demarcation Membrane System; 3 Proplatelet Formation; a The Proplatelet Theory; b Proplatelet Morphogenesis; c The Cytoskeletal Mechanics of Proplatelet Formation; i Microtubules Power Proplatelet Elongation; ii Actin-Dependent Proplatelet Branching; iii Organelle Transport in Proplatelets 327 $aiv Spectrin-Based Membrane Skeleton in Platelet Production v Release of Platelets; B The Sites of Platelet Formation In Vivo; 1 Platelet Formation in the Bone Marrow; 2 Platelet Formation in the Bloodstream; 3 Platelet Formation in the Lung; C Apoptosis and Platelet Production; D Production of Platelets for Infusion; IV Regulation of Megakaryocyte Development and Platelet Formation; V Murine Model Systems and Human Diseases as Tools to Study Platelet Biogenesis; A Transcription Factors; 1 GATA-1; 2 Nuclear Factor-Erythroid 2; B Cytoskeletal Proteins; 1 ?1 Tubulin 327 $a2 Glycoprotein Ib-IX-V Complex 330 $aPLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. 606 $aBlood platelets 606 $aBlood platelet disorders 615 0$aBlood platelets. 615 0$aBlood platelet disorders. 676 $a612.1 676 $a612.1/17 676 $a612.117 701 $aMichelson$b Alan D$01561134 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910785961803321 996 $aPlatelets$93827616 997 $aUNINA