LEADER 02975oam  2200613I  450 
001 9910785130203321
005 20230725025149.0
010   $a0-429-19186-3
010   $a1-282-90323-3
010   $a9786612903236
010   $a1-58488-985-3
024 7 $a10.1201/9781584889854 
035   $a(CKB)2670000000048176
035   $a(EBL)599708
035   $a(OCoLC)663999016
035   $a(SSID)ssj0000423608
035   $a(PQKBManifestationID)11281037
035   $a(PQKBTitleCode)TC0000423608
035   $a(PQKBWorkID)10468412
035   $a(PQKB)10507151
035   $a(MiAaPQ)EBC599708
035   $a(Au-PeEL)EBL599708
035   $a(CaPaEBR)ebr10424663
035   $a(CaONFJC)MIL290323
035   $a(EXLCZ)992670000000048176
100   $a20180331d2010      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aMultiple testing problems in pharmaceutical statistics /$feditors, Alex Dmitrienko, Ajit C. Tamhane, Frank Bretz
210  1$aBoca Raton :$cChapman & Hall/CRC/Taylor & Francis,$d2010.
215   $a1 online resource (323 p.)
225 1 $aChapman & Hall/CRC biostatistics series ;$v33
300   $aDescription based upon print version of record.
311   $a1-58488-984-5 
320   $aIncludes bibliographical references and index.
327   $aCover; Title; Copyright; Contents; Preface; List of Contributors; Chapter 1: Multiplicity Problems in Clinical Trials: A Regulatory Perspective; Chapter 2: Multiple Testing Methodology; Chapter 3: Multiple Testing in Dose-Response Problems; Chapter 4: Analysis of Multiple Endpoints in Clinical Trials; Chapter 5: Gatekeeping Procedures in Clinical Trials; Chapter 6: Adaptive Designs and Confirmatory Hypothesis Testing; Chapter 7: Design and Analysis of Microarray Experiments for Pharmacogenomics; Bibliography; Index
330   $aUseful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. In each chapter, the expert contributors describe important multiplicity problems encountered in pre-clinical and clin
410  0$aChapman & Hall/CRC biostatistics series ;$v33.
606   $aDrugs$xTesting$xStatistical methods
615  0$aDrugs$xTesting$xStatistical methods.
676   $a615/.1901
701   $aDmitrienko$b Alex$01525853
701   $aTamhane$b Ajit C$0102985
701   $aBretz$b Frank$0512836
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910785130203321
996   $aMultiple testing problems in pharmaceutical statistics$93767488
997   $aUNINA