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100   $a20180331d2010      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$a3D cell-based biosensors in drug discovery programs $emicrotissue engineering for high throughput screening /$fWilliam S. Kisaalita
210  1$aBoca Raton [Fla.] :$cCRC Press,$d2010.
215   $a1 online resource (392 p.)
300   $aDescription based upon print version of record.
311   $a1-4398-5904-3 
311   $a1-322-62636-7 
311   $a1-4200-7349-4 
320   $aIncludes bibliographical references and index.
327   $aFront Cover; Dedication; Contents; Preface; Author; Part I. Introduction; Chapter 1. Biosensors and Bioassays; Chapter 2. Target-Driven Drug Discovery; Part II. 3D versus 2D Cultures; Chapter 3. Comparative Transcriptional Profiling and Proteomics; Chapter 4. Comparative Structure and Function; Part III. Emerging Design Principles; Chapter 5. Chemical Microenvironmental Factors; Chapter 6. Spatial and Temporal Microenvironmental Factors; Chapter 7. Material Physical Property and Force Microenvironmental Factors; Chapter 8. Proteomics as a Promising Tool in the Search for 3D Biomarkers
327   $aChapter 9. Readout Present and Near FutureChapter 10. Ready-to-Use Commercial 3D Plates; Part IV. Technology Deployment Challenges and Opportunities; Chapter 11. Challenges to Adopting 3D Cultures in HTS Programs; Chapter 12. Cases for 3D Cultures in Drug Discovery; Chapter 13. Ideal Case Study Design; Appendix A: Patents for 3D Scaffolds; Appendix B: Current Drug Targets; Appendix C: Popular Cell Lines in Drug Discovery; Appendix D: Stem Cells in Drug Discovery; Back Cover
330   $aThis book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information--Provided by publisher.
606   $aPharmaceutical biotechnology
606   $aBiosensors
606   $aHigh throughput screening (Drug development)
615  0$aPharmaceutical biotechnology.
615  0$aBiosensors.
615  0$aHigh throughput screening (Drug development)
676   $a615/.19
700   $aKisaalita$b William Ssempa$f1953,$01483443
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910784909603321
996   $a3D cell-based biosensors in drug discovery programs$93701555
997   $aUNINA