LEADER 04419nam 22009015 450 001 9910784862403321 005 20230810231756.0 010 $a1-281-14091-0 010 $a9786611140915 010 $a3-7643-8296-1 024 7 $a10.1007/978-3-7643-8296-4 035 $a(CKB)1000000000404035 035 $a(EBL)338156 035 $a(OCoLC)370727597 035 $a(SSID)ssj0000176883 035 $a(PQKBManifestationID)11179978 035 $a(PQKBTitleCode)TC0000176883 035 $a(PQKBWorkID)10206484 035 $a(PQKB)11246757 035 $a(DE-He213)978-3-7643-8296-4 035 $a(MiAaPQ)EBC338156 035 $a(Au-PeEL)EBL338156 035 $a(CaPaEBR)ebr10221629 035 $a(CaONFJC)MIL114091 035 $a(PPN)123740274 035 $a(EXLCZ)991000000000404035 100 $a20100301d2008 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Immune Synapse as a Novel Target for Therapy$b[electronic resource] /$fedited by Luis Graca 205 $a1st ed. 2008. 210 1$aBasel :$cBirkhäuser Basel :$cImprint: Birkhäuser,$d2008. 215 $a1 online resource (203 p.) 225 1 $aProgress in Inflammation Research,$x2296-4525 300 $a"Progress in inflammation research". 311 $a3-7643-8295-3 320 $aIncludes bibliographical references and index. 327 $aThe immune synapse and T cell activation: regulation by chemokines -- The induction of regulatory T cells by targeting the immune synapse -- Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology -- Targeting CD4 for the induction of dominant tolerance -- Anti-CD3: from T cell depletion to tolerance induction -- Immune modulation by CD40L blockade -- CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance -- Adhesion molecules as therapeutic targets -- E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within? -- FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells -- Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance -- From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic. 330 $aThe immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell?APC junction. It plays an essential role in the control and nature of the immune response. In recent years several approaches have been developed to reprogram the immune response by targeting molecules involved in the immune synapse. Monoclonal antibodies, such as those targeting the lymphocyte co-receptor, costimulatory and adhesion molecules (CD3, CD4, CD40L, CTLA4-Ig, LFA-1), or altered peptide ligands have been shown capable of inducing immune tolerance in transplantation, autoimmunity and allergy. This volume discusses the progress in the field, from basic science to clinical trials, and the major mechanisms involved. It is of interest to clinicians and researchers working in this area. 410 0$aProgress in Inflammation Research,$x2296-4525 606 $aImmunology 606 $aDiseases 606 $aCytology 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aPharmacology 606 $aAllergy 606 $aImmunology 606 $aDiseases 606 $aCell Biology 606 $aBiomedical Research 606 $aPharmacology 606 $aAllergology 615 0$aImmunology. 615 0$aDiseases. 615 0$aCytology. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aPharmacology. 615 0$aAllergy. 615 14$aImmunology. 615 24$aDiseases. 615 24$aCell Biology. 615 24$aBiomedical Research. 615 24$aPharmacology. 615 24$aAllergology. 676 $a616.079 701 $aGraca$b Luis$cMD.$0678504 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784862403321 996 $aThe Immune Synapse as a Novel Target for Therapy$93850526 997 $aUNINA