LEADER 05302nam 2200685Ia 450 001 9910784654703321 005 20230120004647.0 010 $a1-280-70765-8 010 $a9786610707652 010 $a0-08-046530-7 035 $a(CKB)1000000000364093 035 $a(EBL)281942 035 $a(OCoLC)162131389 035 $a(SSID)ssj0000305883 035 $a(PQKBManifestationID)11925012 035 $a(PQKBTitleCode)TC0000305883 035 $a(PQKBWorkID)10294256 035 $a(PQKB)10799426 035 $a(MiAaPQ)EBC281942 035 $a(Au-PeEL)EBL281942 035 $a(CaPaEBR)ebr10151380 035 $a(CaONFJC)MIL70765 035 $a(EXLCZ)991000000000364093 100 $a20060616d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 12$aA pharmacology primer$b[electronic resource] $etheory, applications, and methods /$fTerry Kenakin 205 $a2nd ed. 210 $aBurlington, MA ;$aLondon $cAcademic Press$dc2006 215 $a1 online resource (319 p.) 300 $aPrevious ed.: London: Elsevier, 2004. 311 $a0-08-057508-0 311 $a0-12-370599-1 320 $aIncludes bibliographical references and index. 327 $aFront cover; A PHARMACOLOGY PRIMER THEORY, APPLICATION, AND METHODS; Copyright page; Foreword to Second Edition; Foreword to First Edition; Table of contents; Chapter 1. What Is Pharmacology?; 1.1 About This Book; 1.2 What Is Pharmacology?; 1.3 The Receptor Concept; 1.4 Pharmacological Test Systems; 1.5 The Nature of Drug Receptors; 1.6 Pharmacological Intervention and the Therapeutic Landscape; 1.7 System-independent Drug Parameters: Affinity and Efficacy; 1.8 What Is Affinity?; 1.9 The Langmuir Adsorption Isotherm; 1.10 What Is Efficacy?; 1.11 Dose-response Curves 327 $a1.12 Chapter Summary and Conclusions1.13 Derivations: Conformational Selections as a Mechanism of Efficacy; References; Chapter 2. How Different Tissues Process Drug Response; 2.1 Drug Response as Seen Through the ''Cellular Veil''; 2.2 The Biochemical Nature of Stimulus-response Cascades; 2.3 The Mathematical Approximation of Stimulus-response Mechanisms; 2.4 System Effects on Agonist Response: Full and Partial Agonists; 2.5 Differential Cellular Response to Receptor Stimulus; 2.6 Receptor Desensitization and Tachyphylaxis; 2.7 The Measurement of Drug Activity 327 $a2.8 Advantages and Disadvantages of Different Assay Formats2.9 Drug Concentration as an Independent Variable; 2.10 Chapter Summary and Conclusions; 2.11 Derivations; References; Chapter 3. Drug-Receptor Theory; 3.1 About This Chapter; 3.2 Drug-Receptor Theory; 3.3 The Use of Mathematical Models in Pharmacology; 3.4 Some Specific Uses of Models in Pharmacology; 3.5 Classical Model of Receptor Function; 3.6 The Operational Model of Receptor Function; 3.7 Two-state Theory; 3.8 The Ternary Complex Model; 3.9 The Extended Ternary Model; 3.10 Constitutive Receptor Activity 327 $a3.11 The Cubic Ternary Complex Model3.12 Chapter Summary and Conclusions; 3.13 Derivations; References; Chapter 4. Pharmacological Assay Formats: Binding; 4.1 The Structure of This Chapter; 4.2 Binding Theory and Experiment; 4.3 Complex Binding Phenomena: Agonist Affinity from Binding Curves; 4.4 Experimental Prerequisites for Correct Application of Binding Techniques; 4.5 Chapter Summary and Conclusions; 4.6 Derivations; References; Chapter 5. Agonists: The Measurement of Affinity and Efficacy in Functional Assays; 5.1 Functional Pharmacological Experiments 327 $a5.2 The Choice of Functional Assays5.3 Recombinant Functional Systems; 5.4 Functional Experiments: Dissimulation in Time; 5.5 Experiments in Real Time Versus Stop Time; 5.6 The Measurement of Agonist Affinity in Functional Experiments; 5.7 Estimates of Relative Efficacy of Agonists in Functional Experiments; 5.8 Chapter Summary and Conclusions; 5.9 Derivations; References; Chapter 6. Orthosteric Drug Antagonism; 6.1 Introduction; 6.2 Kinetics of Drug-Receptor Interaction; 6.3 Surmountable Competitive Antagonism; 6.4 Noncompetitive Antagonism; 6.5 Agonist-Antagonist Hemi-equilibria 327 $a6.6 Resultant Analysis 330 $aThe Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments.*Over 30 new figures and tables*More human interest information to provide readers with historical facts on pharmacology research*New section on therapeutics to help identify diseases and drug treatments*New section on new biological concepts relevant to pharmacological researc 606 $aPharmacology 606 $aDrugs 606 $aChemicals$xPhysiological effect 615 0$aPharmacology. 615 0$aDrugs. 615 0$aChemicals$xPhysiological effect. 676 $a615.1 676 $a615/.7 700 $aKenakin$b Terrence P$0291558 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784654703321 996 $aA pharmacology primer$92610358 997 $aUNINA