LEADER 04403nam 2200601Ia 450 001 9910784644103321 005 20230228230752.0 010 $a1-281-02586-0 010 $a9786611025861 010 $a0-08-054240-9 035 $a(CKB)1000000000364605 035 $a(EBL)299032 035 $a(OCoLC)476075400 035 $a(SSID)ssj0000125243 035 $a(PQKBManifestationID)12018890 035 $a(PQKBTitleCode)TC0000125243 035 $a(PQKBWorkID)10026563 035 $a(PQKB)11395574 035 $a(MiAaPQ)EBC299032 035 $a(PPN)18256892X 035 $a(EXLCZ)991000000000364605 100 $a19971216h19981998 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe combinatorial index /$fBarry A. Bunin 210 1$aSan Diego :$cAcademic Press,$d1998. 210 4$aŠ1998 215 $a1 online resource (xvii, 322 pages) $cillustrations 300 $aDescription based upon print version of record. 311 0 $a0-12-141340-3 320 $aIncludes bibliographical references and indexes. 327 $aFront Cover; THE COMBINATORIAL INDEX; Copyright Page; Contents; Foreword; Acknowledgments; Chapter 1. Introduction; Chapter 2. Background; Chapter 3. Linkers for Solid-Phase Synthesis; 3.1 Resin Derivatization; 3.2 Linkers for Carboxylic Acids; 3.3 Linkers for Amides; 3.4 Linkers for Alcohols and Amines; 3.5 Linkers for Hydrocarbons and Other Functional Groups; Chapter 4. Combinatorial Solid-Phase Synthesis; 4.1 Condensations to Prepare Amides, Esters, Ureas, Imines, and Phosphorus Compounds; 4.2 Carbon-Carbon Bond Formation on Solid Support; 4.3 Mitsunobu Reactions on Solid Support 327 $a4.4 Substitution and Addition Reactions on Solid Support 4.5 Oxidations on Solid Support; 4.6 Reductions on Solid Support; 4.7 Preparation of Heterocyclic Compounds; Chapter 5. Analytical Methods for Solid-Phase Synthesis; 5.1 Colormetric Assays on Solid Support; 5.2 Identification of Compounds Released from Resin; 5.3 NMR Techniques for Solid-Phase Synthesis; 5.4 IR Techniques for Solid-Phase Synthesis; 5.5 Mass Spectrometry Techniques for Solid-Phase Synthesis; 5.6 Other Analytical Methods for Combinatorial Synthesis 327 $aChapter 6. Preparation of Solution Libraries and Combined Approaches at the Solution/Solid-Phase Interface 6.1 Solution Libraries; 6.2 Resin Capture; 6.3 Support-Bound Reagents; Appendix 1. Summary of Functional Group Transformations for Combinatorial Solid-Phase Synthesis; Appendix 2. Classification of Heterocyclization Reactions; Appendix 3. Unnatural Biopolymers; Appendix 4. Oligosaccharides; Appendix 5. List of Abbreviations; Author Index; Subject Index 330 $aWith the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest, "which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. Key Features * Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods * Serves as a laboratory manual for bench chemists * Includes a chapter on linkers to assist in choice of linking strategy * Discusses strengths and limitations of the various methods * Contains a structural index showing functional group transformations in solid-phase synthesis. 606 $aCombinatorial chemistry$vHandbooks, manuals, etc 606 $aPharmaceutical chemistry 615 0$aCombinatorial chemistry 615 0$aPharmaceutical chemistry. 676 $a547.2 676 $a615.19 676 $a615/.19 21 700 $aBunin$b Barry A$01570149 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784644103321 996 $aThe combinatorial index$93843594 997 $aUNINA