LEADER 05556nam 2200685Ia 450 001 9910784598203321 005 20230316164706.0 010 $a1-280-62899-5 010 $a9786610628995 010 $a0-08-046192-1 035 $a(CKB)1000000000357850 035 $a(EBL)269786 035 $a(OCoLC)475999529 035 $a(SSID)ssj0000246622 035 $a(PQKBManifestationID)11923220 035 $a(PQKBTitleCode)TC0000246622 035 $a(PQKBWorkID)10189494 035 $a(PQKB)10347564 035 $a(Au-PeEL)EBL269786 035 $a(CaPaEBR)ebr10138592 035 $a(CaONFJC)MIL62899 035 $a(OCoLC)162130506 035 $a(MiAaPQ)EBC269786 035 $a(EXLCZ)991000000000357850 100 $a20051102d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe skin in systemic autoimmune diseases /$feditors, Piercarlo Sarzi-Puttini [et al.] 205 $aFirst edition. 210 1$aAmsterdam ;$aBoston :$cElsevier,$d2006. 215 $a1 online resource (359 pages) 225 1 $aHandbook of systemic autoimmune diseases ;$vv. 5 300 $aDescription based upon print version of record. 311 0 $a0-444-52158-5 320 $aIncludes bibliographical references and index. 327 $aCover; Preface; Series Editor; Volume Editors; List of Contributors; Contents; The Skin and the Immune System; The Skin as an Immunologic Organ; Introduction: the skin as an organ of defence; Evolving concepts of the skin as an immunological organ; The skin immune system; Immune responses in skin; Conclusions; Key points; References; T Cells and Dendritic Cells in Immuno-Mediated Skin Pathology; Introduction; Self-reactive T cell subsets; Dendritic cells-key regulators of immune responses; Dendritic cells in mixed connective tissue disease; Dendritic cells in Sjo?gren's syndrome 327 $aDendritic cells induce psoriasis Acknowledgments; References; D6 as a Decoy and Scavenger Receptor for Inflammatory CC Chemokines in the Skin; Introduction; Expression and ligand recognition by the D6 chemokine decoy receptor; In vitro properties; D6 as a decoy in the skin; Concluding remarks; Key points; References; Autoantibodies and Skin Involvement in Systemic Autoimmune Diseases; Introduction; Autoantibodies in Systemic Sclerosis (SSc); Pathogenic autoantibodies; Anti-fibroblast antibodies; Anti-endothelial antibodies; Anti-matrix metalloproteinase (MMP) antibodies 327 $aPrognostic autoantibodies Pathogenic autoantibodies in systemic lupus erythematosus: the anti-Ro/SSA model; Clinical and pathogenic associations; Prognostic autoantibodies in other systemic autoimmune diseases; Dermatomyositis (DM); Other myositis; Rheumatoid arthritis (RA); Key points; References; Skin Involvement in Systemic Autoimmune Diseases; Photosensitivity in Lupus Erythematosus; Introduction; Pathophysiology of photosensitivity in LE; Clinical photosensitivity and phototesting; References; Cutaneous Manifestations of Lupus Erythematosus; Introduction 327 $aSpecific cutaneous manifestations of lupus erythematosus Acute cutaneous lupus erythematosus; Subacute cutaneous lupus erythematosus; Chronic cutaneous lupus erythematosus; Discoid lupus erythematosus; Chilblain lupus erythematosus; Lupus erythematosus profundus; Intermittent cutaneous lupus erythematosus; Lupus erythematosus tumidus; Non-specific cutaneous manifestations of lupus erythematosus; Bullous skin lesions in lupus erythematosus; Urticarial Vasculitis; Papulonodular mucinosis; Annular erythema; Conclusions; Acknowledgements; Key points; References 327 $aSubacute Cutaneous Lupus Erythematosus: A Quarter Century's Perspective Introduction and historical perspective; Epidemiology; Incidence and prevalence; Demographics; Environmental influences; Etiology/pathogenesis; Clinical manifestations; Clinical features; Association with other forms of cutaneous LE and LE nonspecific skin disease; Association with SLE; Association with other autoimmune diseases; SCLE as a paraneoplastic phenomenon; Diagnostic investigations; Serology/immunology; Other laboratory features; Differential diagnosis; Treatment; Protection from ultraviolet light; Physical protection 330 $aThis book represents the state-of-the-art in the field of skin and autoimmune rheumatic diseases. It covers systematically a growing and multifaceted topic which is of great importance in the clinical practice. It also serves as a sharp educational tool as each chapter provides summaries and specific highlights to key references cited into the text. The pathophysiological link between skin involvement and autoimmunity has been explained in detail, as well as diagnostic and therapeutic aspects. 410 0$aHandbook of systemic autoimmune diseases ;$v5. 606 $aSkin$xDiseases$xImmunological aspects$vHandbooks, manuals, etc 606 $aCutaneous manifestations of general diseases$vHandbooks, manuals, etc 606 $aAutoimmune diseases$vHandbooks, manuals, etc 615 0$aSkin$xDiseases$xImmunological aspects 615 0$aCutaneous manifestations of general diseases 615 0$aAutoimmune diseases 676 $a616.5/079 701 $aSarzi-Puttini$b Piercarlo$01517949 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784598203321 996 $aThe skin in systemic autoimmune diseases$93755210 997 $aUNINA