LEADER 05586nam 2200685Ia 450 001 9910784594903321 005 20200520144314.0 010 $a1-280-64168-1 010 $a9786610641680 010 $a0-08-046128-X 035 $a(CKB)1000000000357893 035 $a(EBL)270297 035 $a(OCoLC)476003086 035 $a(SSID)ssj0000174903 035 $a(PQKBManifestationID)12065621 035 $a(PQKBTitleCode)TC0000174903 035 $a(PQKBWorkID)10189893 035 $a(PQKB)11621566 035 $a(Au-PeEL)EBL270297 035 $a(CaPaEBR)ebr10138564 035 $a(CaONFJC)MIL64168 035 $a(OCoLC)936845581 035 $a(MiAaPQ)EBC270297 035 $a(EXLCZ)991000000000357893 100 $a20060126d2006 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHuman herpesvirus-6$b[electronic resource] $egeneral virology, epidemiology, and clinical pathology /$feditors, Gerhard Krueger, Dharam Ablashi 205 $a2nd ed. 210 $aAmsterdam ;$aBoston $cElsevier$dc2006 215 $a1 online resource (393 p.) 225 1 $aPerspectives in medical virology,$x0168-7069 ;$vv. 12 300 $aAblashi's name appears first on the earlier edition. 311 $a0-444-52063-5 320 $aIncludes bibliographical references and index. 327 $aCover; Contents; Foreword by Robert Gallo; Foreword by Ronald Glaser and Marshall Williams; Preface; Part I: General Virology; Discovery and Classification of Human Herpesvirus-6 (HHV-6); Discovery; Nomenclature and classification; References; Ultrastructure and Assembly of Human Herpesvirus-6 (HHV-6); Introduction; Herpesvirus-6 assembly and maturation; Three-dimensional structure of HHV-6 capsid; Comparison of the HHV-6 cappsid structure with those of other human herpesviruses; Conclusion; References; HHV-6 Genome: Similar and Different; Genome classification and biology 327 $aGenomes, cellular tropism and laboratory culture Genome structure and repetitive sequence; Genome rearrangements and relationship to other herpes viruses; Genome composition and general molecular biology; Herpes virus conserved and HHV-6-specific genes; Genomes and HHV-6 strains; Acknowledgements; References; Proteins of HHV-6; Introduction; IE proteins; U16/U17; U53, proteinase; U69, kinase; Cellular homologues; U94, AAV-2 rep homologue; Envelope glycoproteins; U39, gB; U48 and U82, gH and gL; U100, gQ; U47, gO; U11; U14; U27; Perspective; References; Biological Features of HHV-6; Introduction 327 $aHHV-6 cellular receptor Species specificity; Cellular tropism of HHV-6; Target cells in vitro; Cellular and tissue host range in vivo; Biological effects of HHV-6 on the host cell; Cytopathic effects; Latent infection; Cellular transformation; Immune modulation; Human lymphoid tissue ex vivo: a new model for the study of HHV-6 pathogenesis; Dysregulation of complement activation; References; Part II: Diagnosis and Epidemiology; Strain Variants of HHV-6; Introduction; Epidemiology; Molecular biology; Biological aspects of variants A and B 327 $aReactivity of monoclonal antibodies to HHV-6 variants A and BDisease associations of HHV-6A and -6B variants; Roseola infantum; CNS disease; Epilepsy and HHV-6B; Transplantation and HHV-6 variants; HHV-6 (variants A and B) and multiple sclerosis; HHV-6A and chronic fatigue syndrome (CFS); Concluding remarks; References; Serologic Testing for Acute and Chronic Infection; Introduction; Serologic assays; Techniques; Immunofluorescence assays; Enzyme immunoassays; Neutralization assays; HHV-6 antigens involved in serologic testing; Characterization of HHV-6-specific antibodies; Serologic findings 327 $aSeroprevalence studies Primary infection; Latent infection and reactivations; Central nervous system diseases; Pending questions and perspectives; Acknowledgments; References; Molecular Testing for HHV-6 Infection; Introduction; Primary infection: characteristics and diagnostic considerations; PCR analysis of cell-free body fluids; Reverse transcription PCR analysis; Quantitative PCR analysis of HHV-6 DNA in PBMC or blood; Detection of virus variants; Other assay approaches; Future assay methods; PCR-based assays: general considerations and molecular underpinnings; Commercially available tests 327 $aGeneral considerations for current molecular assays 330 $aThe present book presents a comprehensive review of Human Herpesvirus-6 (HHV-6) infects up to 90% of the world's population and can cause potentially life-threatening diseases. Clinicians typically do not search for HHV-6, and if they do, they will find only few laboratories providing the necessary diagnostic tests that can differentiate between active and latent infection. Adding to this problem is that scientists still disagree about whether serological or molecular assays will be the best diagnostic test, yet there is no disagreement about the inadequacy of many of the currently existing a 410 0$aPerspectives in medical virology ;$vv. 12. 606 $aHuman herpesvirus-6 606 $aHuman herpesvirus-6 infections 615 0$aHuman herpesvirus-6. 615 0$aHuman herpesvirus-6 infections. 676 $a616.9/101 701 $aKrueger$b G. R. F$01517925 701 $aAblashi$b D. V$g(Dharam V.)$01517926 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784594903321 996 $aHuman herpesvirus-6$93755183 997 $aUNINA