LEADER 05251nam 2200673Ia 450 001 9910784550403321 005 20170815110758.0 010 $a1-280-63058-2 010 $a9786610630585 010 $a0-08-045702-9 024 3 $z9780120885541 035 $a(CKB)1000000000364676 035 $a(EBL)270047 035 $a(OCoLC)476001127 035 $a(SSID)ssj0000204145 035 $a(PQKBManifestationID)12075025 035 $a(PQKBTitleCode)TC0000204145 035 $a(PQKBWorkID)10175665 035 $a(PQKB)11542042 035 $a(MiAaPQ)EBC270047 035 $a(PPN)131309137 035 $a(EXLCZ)991000000000364676 100 $a20050415d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aModels of seizures and epilepsy$b[electronic resource] /$feditors, Asla Pitka?nen, Philip A. Schwartzkroin, Solomon L. Moshe? 210 $aAmsterdam ;$aBoston $cElsevier Academic$dc2006 215 $a1 online resource (705 p.) 300 $aDescription based upon print version of record. 311 $a0-12-088554-9 320 $aIncludes bibliographical references and index. 327 $aTable of Contents; Contributing Authors; Foreword; Preface; CHAPTER 1: What Should Be Modeled?; CHAPTER 2: Single Nerve Cells Acutely Dissociated from Animal and Human Brains for Studies of Epilepsy; CHAPTER 3: Cell Culture Models for Studying Epilepsy; CHAPTER 4: An Overview of In Vitro Seizure Models in Acute and Organotypic Slices; CHAPTER 5: The Use of Brain Slice Cultures for the Study of Epilepsy; CHAPTER 6: Hippocampal Slices: Designing and Interpreting Studies in Epilepsy Research 327 $aCHAPTER 7: Thalamic, Thalamocortical, and Corticocortical Models of Epilepsy with an Emphasis on Absence SeizuresCHAPTER 8: Studying Epilepsy in the Human Brain In Vitro; CHAPTER 9: In Vitro Isolated Guinea Pig Brain; CHAPTER 10: Pharmacologic Models of Generalized Absence Seizures in Rodents; CHAPTER 11: Models of Chemically-Induced Acute Seizures; CHAPTER 12: Electrical Stimulation-Induced Models of Seizures; CHAPTER 13: Alcohol Withdrawal Seizures; CHAPTER 14: Alumina Gel Injection Models of Epilepsy in Monkeys; CHAPTER 15: Modeling Epilepsy and Seizures in Developing Zebrafish Larvae 327 $aCHAPTER 16: Transgenic and Gene Replacement Models of Epilepsy: Targeting Ion Channel and Neurotransmission Pathways in MiceCHAPTER 17: Spontaneous Epileptic Mutations in the Mouse; CHAPTER 18: Genetic Models of Absence Epilepsy in the Rat; CHAPTER 19: Models with Spontaneous Seizures and Developmental Disruption of Genetic Etiology; CHAPTER 20: Mammalian Models of Genetic Epilepsy Characterized by Sensory-Evoked Seizures and Generalized Seizure Susceptibil; CHAPTER 21: Inherited Epilepsy in Mongolian Gerbils; CHAPTER 22: The Cortical Freeze Lesion Model 327 $aCHAPTER 23: MAM and Other "Lesion" Models of Developmental EpilepsyCHAPTER 24: In Utero Irradiation as a Model of Cortical Dysplasia; CHAPTER 25: Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in the Neonatal Period; CHAPTER 26: Complex Febrile Seizures-An Experimental Model in Immature Rodents; CHAPTER 27: Repetitive Seizures in the Immature Brain*; CHAPTER 28: The Kindling Phenomenon; CHAPTER 29: Kindling Kittens and Cats; CHAPTER 30: Electrical Kindling in Developing Rats; CHAPTER 31: Chemical Kindling 327 $aCHAPTER 32: Kindling, Spontaneous Seizures, and the Consequences of Epilepsy: More Than a ModelCHAPTER 33: Tetanus Toxin Model of Focal Epilepsy; CHAPTER 34: Kainate-Induced Status Epilepticus: A Chronic Model of Acquired Epilepsy; CHAPTER 35: The Pilocarpine Model of Seizures; CHAPTER 36: Status Epilepticus: Electrical Stimulation Models; CHAPTER 37: Posttraumatic Epilepsy Induced by Lateral Fluid-Percussion Brain Injury in Rats; CHAPTER 38: Chronic Partial Cortical Isolation; CHAPTER 39: Head Trauma: Hemorrhage-Iron Deposition; CHAPTER 40: Stroke 327 $aCHAPTER 41: Models Available for Infection-Induced Seizures 330 $aAn understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and sei 606 $aEpilepsy 606 $aSpasms 606 $aEpilepsy$xAnimal models 615 0$aEpilepsy. 615 0$aSpasms. 615 0$aEpilepsy$xAnimal models. 676 $a616.853 676 $a616.85307 701 $aPitka?nen$b Asla$0914569 701 $aSchwartzkroin$b P. A$g(Philip A.)$01167723 701 $aMoshe?$b Solomon L$01524867 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784550403321 996 $aModels of seizures and epilepsy$93765934 997 $aUNINA