LEADER 05354nam 22006494a 450 001 9910784546503321 005 20200520144314.0 010 $a1-280-92693-7 010 $a9786610926930 010 $a0-08-049140-5 035 $a(CKB)1000000000364741 035 $a(EBL)294609 035 $a(OCoLC)437181607 035 $a(SSID)ssj0000168443 035 $a(PQKBManifestationID)11149651 035 $a(PQKBTitleCode)TC0000168443 035 $a(PQKBWorkID)10193036 035 $a(PQKB)10417173 035 $a(Au-PeEL)EBL294609 035 $a(CaPaEBR)ebr10186420 035 $a(CaONFJC)MIL92693 035 $a(MiAaPQ)EBC294609 035 $a(PPN)170269086 035 $a(EXLCZ)991000000000364741 100 $a20050818d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHandbook of the biology of aging$b[electronic resource] /$feditors, Edward J. Masoro and Steven N. Austad 205 $a6th ed. 210 $aAmsterdam ;$aBoston $cElsevier Academic Press$dc2006 215 $a1 online resource (681 p.) 225 1 $aThe handbooks of aging 300 $aIncludes bibliographical references and indexes. 311 $a0-12-088387-2 327 $aFront Cover; Handbook of The Biology of Aging; Copyright Page; Contents; Contributors; Foreword; Preface; About the Editors; Section I. Conceptual and Technical Issues; Chapter 1. Reliability Theory of Aging and Longevity; I. Introduction; II. General Overview of the Reliability Theory Approach; III. Mortality, Failure, and Aging in Biological and Technical Systems; IV. Explanations of Aging Phenomena Using Reliability Theory; V. The Idea of High Initial Damage Load: The HIDL Hypothesis; VI. Reliability Models of Aging for Biological Systems; VII. Evolution of Species Reliability 327 $aVIII. ConclusionsReferences; Chapter 2. Are Age-Associated Diseases an Integral Part of Aging?; I. Introduction; II. Concepts of Biological Gerontology; III. Age-Associated Diseases; IV. Primary Aging, Secondary Aging, and "Normal Aging"; V. Evolutionary Theory and Age-Associated Diseases; VI. Analysis of Two Major Age-Associated Disease Processes; VII. Summary and Conclusions; References; Chapter 3. Dietary Restriction, Hormesis, and Small Molecule Mimetics; I. Introduction; II. Key Discoveries; III. Physiological Effects of DR on Mammals; IV. Mechanisms of DR; V. Small-Molecule CR Mimetics 327 $aVI. ConclusionsReferences; Chapter 4. Hematopoietic Stem Cells, Aging, and Cancer; I. Stem Cells; II. Stem Cell Aging; III. Stem Cells and Cancer; IV. Conclusions; References; Chapter 5. Mitochondria: A Critical Role in Aging; I. The Mitochondrion; II. Evidence for Increased Oxidative Damage to Mitochondrial Components with Age; III. Mitochondrial Dysfunction and Aging; IV. Mitochondrial Dysfunction and Age-Associated Disease; V. Conclusions; References; Chapter 6. p53 and Mouse Aging Models; I. Introduction to p53; II. p53 and Cellular Senescence 327 $aIII. Linkage of IGF-1, Sir2, and p53 SignalingIV. Mouse Models of Aging; V. Mouse Models of Accelerated Aging; VI. Mouse Models of Delayed Aging; VII. Links to p53 in Mouse Aging Models; VIII. Mutant Mouse p53 Models, Aging, and Cancer; IX. Influence of p53 on Longevity in Humans; X. How Might p53 Influence Organismal Aging?; References; Chapter 7. Complex Genetic Architecture of Drosophila Longevity; I. Introduction; II. Genome Scan for Quantitative Trait Loci (QTLs); III. Deficiency Complementation Mapping; IV. Complementation Tests to Mutations at Positional Candidate Genes 327 $aV. Linkage Disequilibrium (LD) MappingVI. Conclusions and Future Prospects; References; Chapter 8. Evolutionary Biology of Aging: Future Directions; I. Introduction; II. Genetics of Senescence; III. From Physiology to Demography; IV. Parasites and Immune Function; V. Sex, Sexual Selection, and Sexual Conflict; VI. Genetic Variation in Natural Populations; VII. Conclusions; References; Chapter 9. Senescence in Wild Populations of Mammals and Birds; I. Introduction; II. Evidence of Senescence in Wild Populations; III. Patterns of Senescence 327 $aIV. Methodological Difficulties in Evaluating Senescence in Wild Populations 330 $aThe Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new info 410 0$aHandbooks of aging. 606 $aAging$xPhysiological aspects$vHandbooks, manuals, etc 615 0$aAging$xPhysiological aspects 676 $a612.6/7 701 $aMasoro$b Edward J$01528743 701 $aAustad$b Steven N.$f1946-$0253728 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784546503321 996 $aHandbook of the biology of aging$93772578 997 $aUNINA