LEADER 03160nam 22006134a 450 001 9910784542803321 005 20200520144314.0 010 $a1-281-03696-X 010 $a9786611036966 010 $a0-08-054609-9 035 $a(CKB)1000000000364644 035 $a(EBL)299440 035 $a(OCoLC)476077150 035 $a(SSID)ssj0000157500 035 $a(PQKBManifestationID)11148848 035 $a(PQKBTitleCode)TC0000157500 035 $a(PQKBWorkID)10139645 035 $a(PQKB)10045252 035 $a(MiAaPQ)EBC299440 035 $a(Au-PeEL)EBL299440 035 $a(CaPaEBR)ebr10186727 035 $a(CaONFJC)MIL103696 035 $a(PPN)182565467 035 $a(EXLCZ)991000000000364644 100 $a20070125d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFoundations of comparative genomics$b[electronic resource] /$fArcady R. Mushegian 210 $aAmsterdam ;$aBoston $cAcademic Press$dc2007 215 $a1 online resource (276 p.) 300 $aDescription based upon print version of record. 311 $a0-12-088794-0 320 $aIncludes bibliographical references (p. 238-257) and index. 327 $aThe beginning of computational genomics -- Finding sequence similarities -- Homology: can we get it right? -- Getting ready for the era of comparative genomics: the importance of viruses -- The first fact of comparative genomics: protein sequences are remarkably resilient in evolution -- The second fact of comparative genomics: functional convergence at the molecular level -- Prediction of function and reconstruction of metabolism from genomic data: homology-based approaches -- Prediction of function and reconstruction of metabolism: post-homology approaches -- Structural genomics: what does it tell us about life? -- How many protein families are there? -- Phylogenetic inference and the era of complete genomes -- Two stories about evolution -- Minimal and ancestral genomes -- Comparative genomics and systems biology. 330 $aThis book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as 606 $aGenomics 606 $aGene mapping 606 $aPhysiology, Comparative 615 0$aGenomics. 615 0$aGene mapping. 615 0$aPhysiology, Comparative. 676 $a572.8/6 22 676 $a572.86 700 $aMushegian$b Arcady R$01528715 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784542803321 996 $aFoundations of comparative genomics$93772548 997 $aUNINA