LEADER 05310nam 22006734a 450 001 9910784526703321 005 20170815142307.0 010 $a1-281-05483-6 010 $a9786611054830 010 $a0-08-053703-0 035 $a(CKB)1000000000384331 035 $a(EBL)313713 035 $a(OCoLC)476103415 035 $a(SSID)ssj0000206020 035 $a(PQKBManifestationID)12021777 035 $a(PQKBTitleCode)TC0000206020 035 $a(PQKBWorkID)10214480 035 $a(PQKB)11037270 035 $a(MiAaPQ)EBC313713 035 $a(PPN)182572196 035 $a(EXLCZ)991000000000384331 100 $a20011114d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMouse development$b[electronic resource] $epatterning, morphogenesis, and organogenesis /$fedited by Janet Rossant, Patrick P.L. Tam 210 $aSan Diego $cAcademic Press$dc2002 215 $a1 online resource (731 p.) 300 $aDescription based upon print version of record. 311 $a0-12-597951-7 320 $aIncludes bibliographical references and indexes. 327 $aFront Cover; Mouse Development: Patterning, Morphogenesis, and Organogenesis; Copyright Page; Contents; Contributors; About the Editors; Part I: Establishment of Body Patterns; Chapter 1. Fertilization and Activation of the Embryonic Genome; I. Introduction; II. Oogenesis; III. Meiosis and the Beginning of Oocyte Asymmetry; IV. Fertilization; V. Transcription andlts Control; VI. mRNA Utilization during Oocyte Maturation and Preimplantation Development; VII. Gene Expression in the Early Mouse Embryo; VIII. Functional Analysis; References 327 $aChapter 2. Asymmetry and Prepattern in Mammalian DevelopmentI. Introduction; II. Asymmetries in Early Development; III. Asymmetry of the Blastocyst; IV. Specification of the Polarity of the Anterior-Posterior Axis of the Fetus?; V. Conclusions; References; Chapter 3. Anterior Posterior Patterning of the Mouse Body Axis at Gastrulation; I. Introduction; II. Gastrulation; III. The Node: Morphogenesis, Cell Fate, and Cell Movement; IV. The Organizer Phenomenon: Conserved Properties of Vertebrate Organizers 327 $aV. The Vertebrate Organizer is a Dynamic, Nonhomogeneous, and Renewable Cell Population at GastrulationVI. Insights into the Function of the Mouse Organizer Gained from Genetic and Embryological Studies; VII. Genetic Analysis of Organizer Function: Mouse Mutants Showing Defects in Organizer Function; VIII. Inhibitory Signals Secreted by the Organizer and Its Derivatives; IX. Specification of the Primitive Streak and the Organizer; X. Role of the AVE in Anterior Patterning in Mouse; XI. Embryological and Genetic Analysis of the Function of the AVE in Anterior Patterning 327 $aXII. A Model for AVE Function in Anterior PatterningXIII. Conclusions and Future Directions; References; Chapter 4. Left-Right Asymmetry; I. Introduction; II. Morphological Left-Right Asymmetries; III. Genetic/Molecular Pathway Governing Left- Right Determination; IV. Molecular Readout of the First Asymmetry; V. Role of the Midline; VI. Readout of Left-Right Asymmetry in Later Development; VII. Miscellaneous Mutations/ Gene Factors; VIII. Diversity among Vertebrates; IX. Future Challenges; References; Chapter 5. Patterning, Regionalization, and Cell Differentiation in the Forebrain 327 $aI. Organization of the ForebrainII. Early Patterning and Regional Specification of the Forebrain; III. Morphogenetic Mechanisms in the Forebrain; IV. Control of Neurogenesis and Cell-Type Specification in the Forebrain; References; Chapter 6. Establishment of Anterior-Posterior and Dorsal-Ventral Pattern in the Early Central Nervous System; I. Overview of Early CNS Development and Patterning; II. Anterior-Posterior Patterning of the Mesencephalon and Metencephalon; III. Hindbrain Anterior-Posterior Patterning Involves Segmental Units of Development 327 $aIV. CNS Dorsal-Ventral Patterning Involves a Tug of War between Dorsal and Ventral Signaling 330 $aThis book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference.*Broad-based overview 606 $aMice$xDevelopment 606 $aMice$xPhysiology 606 $aMice as laboratory animals 615 0$aMice$xDevelopment. 615 0$aMice$xPhysiology. 615 0$aMice as laboratory animals. 676 $a571.8/19353 22 676 $a571.81935 676 $a571.819353 676 $a599.35163 701 $aRossant$b Janet$0311379 701 $aTam$b Patrick P. L$01545394 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784526703321 996 $aMouse development$93800305 997 $aUNINA