LEADER 04813nam 22006254a 450 001 9910784300803321 005 20230721025447.0 010 $a1-281-12051-0 010 $a9786611120511 010 $a1-86094-796-4 035 $a(CKB)1000000000336329 035 $a(EBL)312272 035 $a(OCoLC)476099345 035 $a(SSID)ssj0000235930 035 $a(PQKBManifestationID)11199833 035 $a(PQKBTitleCode)TC0000235930 035 $a(PQKBWorkID)10172730 035 $a(PQKB)10179482 035 $a(MiAaPQ)EBC312272 035 $a(WSP)0000P443 035 $a(Au-PeEL)EBL312272 035 $a(CaPaEBR)ebr10188698 035 $a(CaONFJC)MIL112051 035 $a(EXLCZ)991000000000336329 100 $a20071012d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aRenaissance of sickle cell disease research in the genome era$b[electronic resource] /$fBetty Pace 210 $aLondon $cImperial College Press ;$aHackensack, NJ $cDistributed by World Scientific Pub.$dc2007 215 $a1 online resource (394 p.) 300 $aDescription based upon print version of record. 311 $a1-86094-645-3 320 $aIncludes bibliographical references and index. 327 $aContents; PART I: THE HUMAN GENOME ERA, A HISTORIC PERSPECTIVE; PART II: CLINICAL RESEARCH PERSPECTIVES; PART III: BASIC RESEARCH PERSPECTIVES; PART IV: COMMUNITY PERSPECTIVES; Contributors; Foreword Francis S. Collins and Alan E. Guttmacher; Acknowledgments; Introduction . . .The Journey Inward Betty S. Pace; 1. Sickle Cell Disease: Demystifying the Beginnings Clarice Reid and Griffin Rodgers; 2. Sponsorship of Sickle Cell Disease Research by the National Institutes of Health: A Brief History and Projections for the Future Gregory L. Evans and David G. Badman 327 $a3. The Human Genome Project Betty S. Pace4. Sickle Cell Disease: A Phenotypic Patchwork Kim Smith-Whitley and Betty S. Pace; 5. Preventive Care and Advances in the Treatment of Sickle Cell Disease Charles T. Quinn and George R. Buchanan; 6. Sickle Cell Disease in Adults Johnson Haynes, Jr. and Ardie Pack-Mabien; 7. Pain in Sickle Cell Disease: A Multidimensional Construct Lennette J. Benjamin and Richard Payne; 8. Transfusion Therapy in Sickle Cell Disease Carolyn Hoppe, Robert Adams and Elliot Vichinsky; 9. Hemoglobin S Polymerization, Just the Beginning Frank A. Ferrone 327 $a10. Damage to the Red Blood Cell Membrane in Sickle Cell Disease Steven R. Goodman and Clinton Joiner11. Fetal Hemoglobin for What Ails Sickle Hemoglobin Solomon F. Ofori-Acquah and Betty S. Pace; 12. Genetic Modulation of Sickle Cell Disease Martin H. Steinberg and Swee Lay Thein; 13. Molecular Framework of Hemoglobin Switching Steven Fiering; 14. Dynamic Nucleoprotein Structure of the ß-Globin Locus: Establishing a Rational Molecular Basis for Therapeutic Modulation o 327 $a15. Vertebrate Models for Sickle Cell Disease Research Barry H. Paw, Seong-Kyu Choe, Flavia C. Costa, Shirin V. Sundar and Kenneth Peterson16. Stem Cell Biology Wei Li and Alan W. Flake; 17. Bone Marrow Transplantation Robert I. Raphael and Mark C. Walters; 18. Genetically Engineered Cures: Gene Therapy for Sickle Cell Disease Punam Malik and Philippe Leboulch; 19. Sickle Cell Disease: The Past, Present and Future Social and Ethical Dilemmas Vence L. Bonham, Jr., Carlton Haywood, Jr. and Vanessa Northington Gamble 327 $a20. It Takes a Village to Cure Sickle Cell Disease Rosie Peterson and Denise Davis-Maye21. Beyond National Borders: A Global Perspective on Advances in Sickle Cell Disease Research and Management, and New Challenges in the Genome Era Solomon F. Ofori-Acquah and Kwaku Ohene-Frempong; Index 330 $aThe Human Genome Project has spawned a Renaissance of research faced with the daunting expectation of personalized medicine for individuals with sickle cell disease in the Genome Era. This book offers a comprehensive and timeless account of emerging concepts in clinical and basic science research, and community concerns of health disparity to educate professionals, students and the general public about meeting this challenging expectation. Contributions from physicians, research scientists, scientific administrators and community workers make Renaissance of Sickle Cell Disease Research in the 606 $aSickle cell anemia 606 $aGenomics 615 0$aSickle cell anemia. 615 0$aGenomics. 676 $a616.1527 700 $aPace$b Betty$01512784 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784300803321 996 $aRenaissance of sickle cell disease research in the genome era$93746875 997 $aUNINA