LEADER 03420oam 2200661I 450 001 9910783946603321 005 20230422044339.0 010 $a0-429-27124-7 010 $a1-4822-8341-7 010 $a1-280-07237-7 010 $a0-203-30427-6 010 $a9786610072378 024 7 $a10.4324/9781482283419 035 $a(CKB)1000000000255939 035 $a(EBL)172381 035 $a(OCoLC)475879893 035 $a(SSID)ssj0000285184 035 $a(PQKBManifestationID)12113797 035 $a(PQKBTitleCode)TC0000285184 035 $a(PQKBWorkID)10262241 035 $a(PQKB)10555437 035 $a(MiAaPQ)EBC172381 035 $a(Au-PeEL)EBL172381 035 $a(CaPaEBR)ebr10061048 035 $a(CaONFJC)MIL7237 035 $a(OCoLC)1000438508 035 $a(EXLCZ)991000000000255939 100 $a20180706d1999 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aUsing CNS autopsy tissue in psychiatric research $ea practical guide /$fedited by Brian Dean, Joel E. Kleinman and Thomas M. Hyde 210 1$aAmsterdam :$cHarwood Academic Publishers,$d1999. 215 $a1 online resource (188 p.) 300 $aDescription based upon print version of record. 311 $a0-203-35364-1 311 $a90-5702-298-2 320 $aIncludes bibliographical references and index. 327 $aBook Cover; Title; Contents; Foreword; Contributors; The Collection of Tissue at Autopsy: Practical and Ethical Issues; Psychiatric Diagnosis After Death: The Problems of Accurate Diagnosis from Case History Review and Relative Interviews; Membrane Binding Assays: Membrane Preparation and Assay Development; The Localisation and Quantification of Molecular Changes in the Human Brain Using In Situ Radioligand Binding and Autoradiography; In Situ Hybridisation Histochemistry: Application to Human Brain Tissue; Immunohistochemistry Techniques Applicable for Use with Human Brain Tissue 327 $aThe Processing and Use of Postmortem Human Brain Tissue for Electron MicroscopyIsolating Components of Human Brain: The Purification of A and the Alzheimer's Amyloid Precursor Protein; Analysis of Receptor Systems in Schizophrenia Using Tissue Obtained at Autopsy and Neuroimaging; Index 330 $aEssential for the laboratory, this practical manual presents a wide variety of techniques associated with the use of human CNS tissue obtained at autopsy. The book contains detailed methodologies in discrete chapters written by an expert in the specific field. It also addresses the potential for extending molecular studies in brain tissue obtained at autopsy into studies in living brain by using neuroimaging techniques. In addition, the reader is directed to suppliers of equipment and reagents that have been shown to be useful when studying human brain tissue. 606 $aPsychiatry$xResearch 606 $aNeuropsychiatry 615 0$aPsychiatry$xResearch. 615 0$aNeuropsychiatry. 676 $a611.0188 701 $aDean$b Brian$cDr.$01496045 701 $aHyde$b Thomas M$g(Thomas Michael),$f1957-$01496046 701 $aKleinman$b Joel E.$f1945-$01496047 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910783946603321 996 $aUsing CNS autopsy tissue in psychiatric research$93720497 997 $aUNINA