LEADER 03247oam 2200685I 450 001 9910783846803321 005 20230422044313.0 010 $a0-429-17691-0 010 $a1-4822-9821-X 010 $a1-280-07171-0 010 $a9786610071715 010 $a0-203-30365-2 024 7 $a10.1201/9781482298215 035 $a(CKB)1000000000253714 035 $a(EBL)181540 035 $a(OCoLC)437084398 035 $a(SSID)ssj0000284179 035 $a(PQKBManifestationID)11256034 035 $a(PQKBTitleCode)TC0000284179 035 $a(PQKBWorkID)10261017 035 $a(PQKB)11112240 035 $a(OCoLC)647436282 035 $a(MiAaPQ)EBC181540 035 $a(Au-PeEL)EBL181540 035 $a(CaPaEBR)ebr10099677 035 $a(CaONFJC)MIL7171 035 $a(OCoLC)1000433960 035 $a(EXLCZ)991000000000253714 100 $a20180706d1999 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSignalling pathways in apoptosis /$fedited by Dianne Watters and Martin Lavin 210 1$aAmsterdam :$cHarwood Academic,$d1999. 215 $a1 online resource (338 p.) 225 1 $aModern genetics,$x1056-4497 ;$vv. 5 300 $aDescription based upon print version of record. 311 $a0-203-35369-2 311 $a90-5702-392-X 320 $aIncludes bibliographical references and index. 327 $aBook Cover; Title; Contents; Preface to the Series; Preface; Contributors; Overview: A Matter of Life and Death; The Death Receptors; The Role of Sphingolipids in Stress Responses and Apoptosis in Eukaryotes; Radiation Response Pathways and Apoptosis; Kinase Cascades and Apoptosis; Protein Kinase C Isoenzymes: Evidence for Selectivity in the Regulation of Apoptosis; Apoptosis in Drosophila; Baculoviral Lessons in Apoptosis; The Mitochondrion: Decisive for Cell Death Control?; Caspases and the Commitment to Death; Caspases: The Molecular Effectors of Apoptosis; Killer Cells 327 $aDeliverers of Exogenous Death ProteasesSubstrates of Cell Death Proteases and their Role in Apoptosis; Index 330 $aApoptosis, or programmed cell death, is a necessary process by which a cell may die without adversely affecting its environment. It plays a crucial role in normal development, and in the body's defence mechanisms against disease. Too much cell death is destructive, leading to neurodegenerative diseases and impaired development. Conversely, too little cell death can lead to an increased susceptibility to cancer and sustained viral infection. Apoptosis is a matter of balanceDramatic progress has been made in the study of apoptosis over the past decade. One of the most rapidly expanding knowl 410 0$aModern genetics ;$vv. 5. 606 $aApoptosis 606 $aCellular signal transduction 615 0$aApoptosis. 615 0$aCellular signal transduction. 676 $a571.936 701 $aLavin$b Martin$f1943-$01543903 701 $aWatters$b Dianne$f1952-$01543904 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910783846803321 996 $aSignalling pathways in apoptosis$93797658 997 $aUNINA