LEADER 04595nam 2200649Ia 450 001 9910783762003321 005 20230912152315.0 010 $a1-282-86104-2 010 $a9786612861048 010 $a0-7735-7094-2 024 7 $a10.1515/9780773570948 035 $a(CKB)1000000000244985 035 $a(SSID)ssj0000282489 035 $a(PQKBManifestationID)11244913 035 $a(PQKBTitleCode)TC0000282489 035 $a(PQKBWorkID)10335882 035 $a(PQKB)10933985 035 $a(CaPaEBR)400285 035 $a(CaBNvSL)gtp00521541 035 $a(Au-PeEL)EBL3330725 035 $a(CaPaEBR)ebr10132908 035 $a(CaONFJC)MIL286104 035 $a(OCoLC)929120715 035 $a(DE-B1597)657971 035 $a(DE-B1597)9780773570948 035 $a(VaAlCD)20.500.12592/dk559b 035 $a(schport)gibson_crkn/2009-12-01/1/400285 035 $a(MiAaPQ)EBC3330725 035 $a(MiAaPQ)EBC3243403 035 $a(EXLCZ)991000000000244985 100 $a20021008d2003 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Ontario Cancer Institute$b[electronic resource] $esuccesses and reverses at Sherbourne Street /$fE.A. McCulloch 210 $aMontreal $cMcGill-Queen's University Press$dc2003 215 $ax, 183 p. $cill., ports. ;$d24 cm 225 1 $aMcGill-Queen's/Associated Medical Services (Hannah Institute) studies in the history of medicine, health, and society ;$v19 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-7735-2525-4 320 $aIncludes bibliographical references and index. 327 $tFront Matter -- $tContents -- $tPreface -- $tBeginnings -- $tFirst Research Programs -- $tLeadership and Style -- $tNormal and Malignant Stem Cells -- $tGrowth and Change -- $tImmunology and Hematology Using Cell Culture Methods -- $tPhysics and Radiation Therapy -- $tThe Middle Years, 1971?1981 -- $tInterface Research -- $tThe Style of Ray Bush as Director -- $tResponse to the Crisis of Space and Equipment -- $tPreparing to Move -- $tLast Days on Sherbourne Street -- $tGlossary -- $tIndex 330 $aTo achieve this goal the institute divided its operation into four strands: two of the strands were the research areas - the study of advanced radiation therapy and biology, which worked separatively but cooperatively; a third was patient care; and the fourth element was leadership, provided by the clinical chiefs, the heads of the research divisions, and the administration, in particular the institute's first administrator, John Law. Together these strands helped create a philosophy that made the Ontario Cancer Institute unique and provided the basis for its national and international success. Essential to these successes was a new graduate department, Medical Biophysics, based in the University of Toronto School of Graduate Studies. This department, which provided an innovative, research-based doctoral and masters program, meant that the OCI could accurately be described as a centre for cancer treatment, research, and education. McCulloch describes how the first quantitative assay for stem cells played a major role in bringing OCI research to the international stage as well as influencing other science and much of the clinical thinking in the Institute. Other major advances that brought international recognition have been the identification of the mechanisms that allow cancer cells to resist death from the effects of a variety of different tumours and the isolation of the gene that encodes the T cell receptor, a critical part of the immune apparatus for dealing with foreign cells and viruses. McCulloch also details how lack of space to meet growing demands was a continuing source of frustration and disagreement, and how sometimes serious interpersonal problems hindered the forward thrust of development. Describing these events as well as institute's successes, he provides an insight into the history of Canada's premier cancer research centre. 410 0$aMcGill-Queen's/Associated Medical Services (Hannah Institute) studies in the history of medicine, health, and society ;$v19. 606 $aCancer$xResearch$zOntario$xHistory$y20th century 615 0$aCancer$xResearch$xHistory 676 $a616.99/4/00720713541 700 $aMcCulloch$b Ernest A.$f1926-2011.$01579632 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910783762003321 996 $aThe Ontario Cancer Institute$93859851 997 $aUNINA