LEADER 03931nam 2200685Ia 450 001 9910783324403321 005 20230617015838.0 010 $a1-280-26683-X 010 $a9786610266838 010 $a1-4237-0987-X 010 $a1-84642-016-4 035 $a(CKB)1000000000032561 035 $a(EBL)290571 035 $a(OCoLC)567971109 035 $a(SSID)ssj0000136332 035 $a(PQKBManifestationID)11954128 035 $a(PQKBTitleCode)TC0000136332 035 $a(PQKBWorkID)10083077 035 $a(PQKB)11539749 035 $a(MiAaPQ)EBC290571 035 $a(Au-PeEL)EBL290571 035 $a(CaPaEBR)ebr10082327 035 $a(CaONFJC)MIL26683 035 $a(EXLCZ)991000000000032561 100 $a20040113d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDeliberate self-harm in adolescence$b[electronic resource] /$fClaudine Fox and Keith Hawton 210 $aLondon $cJessica Kingsley Pub.$d2004 215 $a1 online resource (146 p.) 225 1 $aChild and adolescent mental health series 300 $aDescription based upon print version of record. 311 $a1-84985-605-2 311 $a1-84310-237-4 320 $aIncludes bibliographical references and index. 327 $aDeliberate Self-Harm in Adolescence; Contents; Acknowledgements; Preface; 1 Introduction; 2 The Prevalence of Suicidal Behaviour in Adolescence; Deliberate self-harm in adolescents: Oxford patient data; Deliberate self-harm in adolescents: national survey data; Summary points; 3 Risk Factors for Adolescent Suicidal Behaviour; Models of suicidal behaviour; Personal characteristics as risk factors; Psychiatric disorders as risk factors; Family risk factors; The media; Summary points; 4 Identifying At-Risk Adolescents; Screening instruments for the identification of at-risk individuals 327 $aSummary points5 Services for Adolescents; Commissioning services; Delivering services; Summary points; 6 The Outcome of Suicidal Behaviour in Adolescence; Child to adult follow-up; Summary points; 7 Managing Adolescent Suicidal Behaviour; Immediate and general hospital management; Aftercare; The efficacy of aftercare and its outcome; Summary points; 8 Preventing Adolescent Suicidal Behaviour; School-based educational suicide prevention programmes; Screening programmes for at-risk individuals in schools; Weapon control; Crisis intervention centres; Reduction of substance abuse 327 $aMore responsible media reportingPrevention of repetition of self-harm; Summary points; 9 Future Prospects; Conclusions; Messages to take away; Future research; Resources; Appendix; Searching the literature; Quality of research; Criteria for considering papers; Criteria for considering papers for critical appraisal; References; Subject Index; Author Index; About FOCUS 330 $aThe authors discuss risk factors for self-harm, including depression, substance abuse and antisocial behaviour, and critically examine key screening instruments that can be used to assess risk. They describe how suicidal behaviour can be managed and prevented, and look at the effectiveness of aftercare treatment for those who self-harm. 410 0$aChild and adolescent mental health series. 606 $aAdolescent psychology 606 $aChild psychology 606 $aSelf-destructive behavior in children 615 0$aAdolescent psychology. 615 0$aChild psychology. 615 0$aSelf-destructive behavior in children. 676 $a618.928582 700 $aFox$b Claudine$01543447 701 $aHawton$b Keith$f1942-$01543448 712 02$aRoyal College of Psychiatrists.$bResearch Unit. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910783324403321 996 $aDeliberate self-harm in adolescence$93796925 997 $aUNINA LEADER 06384nam 2201969z- 450 001 9910346858503321 005 20210211 035 $a(CKB)4920000000095082 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40775 035 $a(oapen)doab40775 035 $a(EXLCZ)994920000000095082 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAMP-Activated Protein Kinase Signalling 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 online resource (452 p.) 311 08$a3-03897-662-8 330 $aStarting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. 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