LEADER 03851nam 2200745 a 450 001 9910782697803321 005 20230828200741.0 010 $a1-281-30751-3 010 $a9786611307516 010 $a92-4-068249-X 035 $a(CKB)1000000000689235 035 $a(EBL)329002 035 $a(OCoLC)213772601 035 $a(SSID)ssj0000294931 035 $a(PQKBManifestationID)12071167 035 $a(PQKBTitleCode)TC0000294931 035 $a(PQKBWorkID)10315392 035 $a(PQKB)10095882 035 $a(MiAaPQ)EBC329002 035 $a(Au-PeEL)EBL329002 035 $a(CaPaEBR)ebr10214528 035 $a(CaONFJC)MIL130751 035 $a(EXLCZ)991000000000689235 100 $a20081023d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aElemental speciation in human health risk assessment$b[electronic resource] /$ffirst draft prepared by P. Apostoli ... [et al.] 210 $aGeneva $cWorld Health Organization$d2006 215 $a1 online resource (256 p.) 225 1 $aEnvironmental health criteria,$x0250-863X ;$v234 300 $a"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals." 311 $a92-4-157234-5 320 $aIncludes bibliographical references and index. 327 $aTITLE; COPYRIGHT; CONTENTS; NOTE TO READERS OF THE CRITERIA MONOGRAPHS; PREAMBLE; WHO TASK GROUP ON ENVIRONMENTAL HEALTH CRITERIA FOR ELEMENTAL SPECIATION IN HUMAN HEALTH RISK ASSESSMENT; ACRONYMS AND ABBREVIATIONS; 1. SUMMARY; 2. DEFINITIONS OF SPECIES AND SPECIATION; 3. STRUCTURAL ASPECTS OF SPECIATION; 4. ANALYTICAL TECHNIQUES AND METHODOLOGY; 5. BIOACCESSIBILITY AND BIOAVAILABILITY; 6. TOXICOKINETICS AND BIOLOGICAL MONITORING; 7. MOLECULAR AND CELLULAR MECHANISMS OF METAL TOXICITY; 8. HEALTH EFFECTS; 9. CONCLUSIONS AND RECOMMENDATIONS; REFERENCES; RESUME; RESUMEN; INDEX OF ELEMENTS; 330 $aThe purpose of this book is to assess, evaluate, and give guidance on the role of elemental speciation and speciation analysis in human health hazard and risk assessment. The book is directed at risk assessors and regulators, to emphasize the importance of consideration of speciation in their deliberations. To date, this issue has not been a part of most hazard and risk assessments. 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