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010   $a1-281-30751-3
010   $a9786611307516
010   $a92-4-068249-X
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035   $a(EBL)329002
035   $a(OCoLC)213772601
035   $a(SSID)ssj0000294931
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035   $a(PQKBTitleCode)TC0000294931
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100   $a20081023d2006      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aElemental speciation in human health risk assessment$b[electronic resource] /$ffirst draft prepared by P. Apostoli ... [et al.]
210   $aGeneva $cWorld Health Organization$d2006
215   $a1 online resource (256 p.)
225 1 $aEnvironmental health criteria,$x0250-863X ;$v234
300   $a"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."
311   $a92-4-157234-5 
320   $aIncludes bibliographical references and index.
327   $aTITLE; COPYRIGHT; CONTENTS; NOTE TO READERS OF THE CRITERIA MONOGRAPHS; PREAMBLE; WHO TASK GROUP ON ENVIRONMENTAL HEALTH CRITERIA FOR ELEMENTAL SPECIATION IN HUMAN HEALTH RISK ASSESSMENT; ACRONYMS AND ABBREVIATIONS; 1. SUMMARY; 2. DEFINITIONS OF SPECIES AND SPECIATION; 3. STRUCTURAL ASPECTS OF SPECIATION; 4. ANALYTICAL TECHNIQUES AND METHODOLOGY; 5. BIOACCESSIBILITY AND BIOAVAILABILITY; 6. TOXICOKINETICS AND BIOLOGICAL MONITORING; 7. MOLECULAR AND CELLULAR MECHANISMS OF METAL TOXICITY; 8. HEALTH EFFECTS; 9. CONCLUSIONS AND RECOMMENDATIONS; REFERENCES; RESUME; RESUMEN; INDEX OF ELEMENTS; 
330   $aThe purpose of this book is to assess, evaluate, and give guidance on the role of elemental speciation and speciation analysis in human health hazard and risk assessment. The book is directed at risk assessors and regulators, to emphasize the importance of consideration of speciation in their deliberations. To date, this issue has not been a part of most hazard and risk assessments. Further aims of the publication are to encourage the analysis of speciation of elements to increase knowledge on the effect of speciation on mode of action and to increase understanding of health effects.
410  0$aEnvironmental health criteria ;$v234.
606   $aTrace elements$xSpeciation
606   $aHealth risk assessment
606   $aBiological monitoring
606   $aBioavailability
606   $aAnalytical toxicology
606   $aChemical elements$xPhysiological effect
615  0$aTrace elements$xSpeciation.
615  0$aHealth risk assessment.
615  0$aBiological monitoring.
615  0$aBioavailability.
615  0$aAnalytical toxicology.
615  0$aChemical elements$xPhysiological effect.
676   $a615.9515
701   $aApostoli$b P$g(Pietro)$01539499
712 02$aInternational Program on Chemical Safety.
712 02$aWorld Health Organization.
712 02$aUnited Nations Environment Programme.
712 02$aInternational Labour Organisation.
712 02$aInter-Organization Programme for the Sound Management of Chemicals.
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910782697803321
996   $aElemental speciation in human health risk assessment$93790435
997   $aUNINA