LEADER 05507oam 2200649Ia 450 001 9910782552403321 005 20231127161727.0 010 $a1-282-73750-3 010 $a9786612737503 010 $a0-08-093272-X 035 $a(CKB)1000000000577411 035 $a(EBL)428487 035 $a(OCoLC)437112372 035 $a(SSID)ssj0000137819 035 $a(PQKBManifestationID)12053677 035 $a(PQKBTitleCode)TC0000137819 035 $a(PQKBWorkID)10096484 035 $a(PQKB)10655567 035 $a(Au-PeEL)EBL428487 035 $a(CaPaEBR)ebr10286080 035 $a(CaONFJC)MIL273750 035 $a(MiAaPQ)EBC428487 035 $a(EXLCZ)991000000000577411 100 $a20080919d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDeveloping solid oral dosage forms$epharmaceutical theory and practice /$fexecutive editors, Yihong Qiu, Yisheng Chen, Geoff G.Z. Zhang ; associate editors, Linong Liu, William R. Porter 205 $a1st ed. 210 $aAmsterdam ;$aBoston ;$aLondon $cAcademic$d2009 215 $a1 online resource (976 pages) 300 $aDescription based upon print version of record. 311 0 $a0-444-53242-0 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice; Copyright Page; Contents; List of Contributors; Foreword; PART I: THEORIES AND TECHNIQUES IN THE CHARACTERIZATION OF DRUG SUBSTANCES AND EXCIPIENTS; Chapter 1. Solubility of Pharmaceutical Solids; 1.1 Introduction; 1.1.1 Implication of Solubility in Dosage Form Development; 1.1.2 Basic Concepts of Solubility and Dissolution; 1.2 Thermodynamics of Solutions; 1.2.1 Volume of Mixing; 1.2.2 Enthalpy of Mixing; 1.2.3 Entropy of Mixing; 1.2.4 Free Energy of Mixing; 1.3 Theoretical Estimation of Solubility 327 $a1.3.1 Ideal Solutions; 1.3.2 Effect of Crystallinity; 1.3.3 Non-ideal Solutions; 1.3.4 Regular Solution Theory; 1.3.5 Aqueous Solution Theory; 1.3.6 The General Solubility Equation (GSE); 1.4 Solubilization of Drug Candidates; 1.4.1 Solubility Enhancement by pH Control and Salt Formation; 1.4.2 Solubilization Using Complexation; 1.4.3 Solubilization by Cosolvents; 1.4.4 Solubilization by Surfactants (Micellar Solubilization); 1.4.5 Solubilization by Combination of Approaches; 1.5 Experimental Determination of Solubility; 1.5.1 Stability of Solute and Solvent; 1.5.2 Shakers and Containers 327 $a1.5.3 Presence of Excess Undissolved Solute; 1.5.4 Determination of Equilibrium; 1.5.5 Phase-separation; 1.5.6 Determination of Solute Content in the Dissolved Phase; 1.5.7 Experimental Conditions; Chapter 2. Crystalline and Amorphous Solids; 2.1 Introduction; 2.2 Definitions and Categorization of Solids; 2.3 Thermodynamics and Phase Diagrams; 2.3.1 Polymorphs; 2.3.2 Solvates/Hydrates; 2.3.3 Cocrystals; 2.3.4 Amorphous Solids; 2.4 Pharmaceutical Relevance and Implications; 2.4.1 Solubility; 2.4.2 Dissolution Rate and Bioavailability; 2.4.3 Hygroscopicity; 2.4.4 Reactivity and Chemical Stability 327 $a2.4.5 Mechanical Properties; 2.5 Transformations Among Solids; 2.5.1 Induced by Heat; 2.5.2 Induced by Vapor; 2.5.3 Induced by Solvents; 2.5.4 Induced by Mechanical Stresses; 2.6 Methods of Generating the Solids; 2.6.1 Through Gas; 2.6.2 Through Liquid; 2.6.3 Through Solid; 2.7 Amorphous Drugs and Solid Dispersions; 2.7.1 Characteristics of Amorphous Phases; 2.7.2 Characteristics of Amorphous Solid Dispersions; 2.7.3 Crystallization of Amorphous Drug and Dispersions; 2.8 Special Topics; 2.8.1 Polymorph Screening and Stable Form Screening; 2.8.2 High Throughput Crystallization 327 $a2.8.3 Miniaturization in Crystallization; Chapter 3. Analytical Techniques in Solid-state Characterization; 3.1 Introduction; 3.2 Review of Analytical Techniques and Methods; 3.3 Microscopic Methods; 3.3.1 Optical Microscopy; 3.3.2 Electron Microscopy; 3.4 Thermal Analysis; 3.4.1 Differential Scanning Calorimetry; 3.4.2 Thermogravimetric Analysis; 3.4.3 Microcalorimetry; 3.5 Diffraction Methods; 3.5.1 Single-crystal X-ray Diffraction; 3.5.2 Powder X-ray Diffraction; 3.6 Vibrational Spectroscopy; 3.6.1 Infrared Spectroscopy; 3.6.2 Raman Spectroscopy; 3.6.3 Near-infrared ; 3.7 Solid-State Nuclear Magnetic Resonance Spectroscopy 330 $aThis book is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. 606 $aSolid dosage forms 606 $aSolid dosage forms$xResearch 615 0$aSolid dosage forms. 615 0$aSolid dosage forms$xResearch. 676 $a615.19 701 $aQiu$b Yihong$01462422 701 $aChen$b Yisheng$c(Of Novast Laboratories)$01462423 701 $aZhang$b Geoff G. Z$01462424 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910782552403321 996 $aDeveloping solid oral dosage forms$93671408 997 $aUNINA